One of the things I have noticed in the last couple of years is the following paradox.
Food that is potent anti-endotoxin is almost always also anti-thyroid.
And food that is pro-thyroid is often also increasing endotoxin.
Almost as if you have ying (anti-endotoxin) food and yang (pro-thyroid) food, which needs to be carefully balanced.
For example, the following study shows that orange juice, besides its exceptional anti-endotoxin effects, is also anti-thyroid:
Citrus sinensis is a rich source of isoflavonoids and phenolic acids. Much attention has been paid to the beneficial anti-oxidant effect of this natural phenolic acids.5,6 This has led to their proposed use as anti-carcinogens7 and cardioprotective agents,8 these and other reasons has prompted a dramatic increase in their consumption as dietary supplements.
The phytochemicals like isoflavones found in Citrus sinenesis has anti-peroxidative activity.9 Studies have shown that Citrus sinensis extract significantly decreases the level of serum thyroxine (T4) in rats.10 The anti-thyroidal role of Citrus sinensis might be mediated through the inhibition of thyroid peroxidase (TPO)11 the key enzyme in thyroid hormone biosynthesis, as it contains the phenolic compound naringin, which inhibits the activity of TPO.11,12,13 Due to its anti-peroxidative activity, Citrus sinensis extract has anti-thyroidal properties, which suggest its potential to ameliorate hyperthyroidism.14
Even more effective anti-thyroid than the official hyperthyroid drug carbimazole.
I wonder if this is a reason that Ray Peat and Danny Roddy both need to supplement with thyroid while drinking so much orange juice.
I have personally tried orange juice, but it always leaves me cold. I thought it was the amount of liquid, or the lack of salt, or whatever, but maybe it is just the orange juice itself?
Another study showing the same effect for flavanoids in orange juice:
Most flavonoids tested were potent inhibitors of TPO, with IC50 values ranging from 0.6 to 41 microM. Inhibition by the more potent compounds, fisetin, kaempferol, naringenin, and quercetin, which contain a resorcinol moiety, was consistent with mechanism-based inactivation of TPO as previously observed for resorcinol and derivatives. Other flavonoids inhibited TPO by different mechanisms, such as myricetin and naringin, showed noncompetitive inhibition of tyrosine iodination with respect to iodine ion and linear mixed-type inhibition with respect to hydrogen peroxide.
Food that is potent anti-endotoxin is almost always also anti-thyroid.
And food that is pro-thyroid is often also increasing endotoxin.
Almost as if you have ying (anti-endotoxin) food and yang (pro-thyroid) food, which needs to be carefully balanced.
For example, the following study shows that orange juice, besides its exceptional anti-endotoxin effects, is also anti-thyroid:
Comparative effect of Citrus sinensis and carbimazole on serum T4, T3 and TSH levels
There are previous independent reports on the anti-thyroid property of Citrus sinensis. This isoflavones and phenolic acid-rich natural agent is widely consumed as dietary supplement, thus the need to investigate its comparative effect with a standard ...
www.ncbi.nlm.nih.gov
Citrus sinensis is a rich source of isoflavonoids and phenolic acids. Much attention has been paid to the beneficial anti-oxidant effect of this natural phenolic acids.5,6 This has led to their proposed use as anti-carcinogens7 and cardioprotective agents,8 these and other reasons has prompted a dramatic increase in their consumption as dietary supplements.
The phytochemicals like isoflavones found in Citrus sinenesis has anti-peroxidative activity.9 Studies have shown that Citrus sinensis extract significantly decreases the level of serum thyroxine (T4) in rats.10 The anti-thyroidal role of Citrus sinensis might be mediated through the inhibition of thyroid peroxidase (TPO)11 the key enzyme in thyroid hormone biosynthesis, as it contains the phenolic compound naringin, which inhibits the activity of TPO.11,12,13 Due to its anti-peroxidative activity, Citrus sinensis extract has anti-thyroidal properties, which suggest its potential to ameliorate hyperthyroidism.14
Even more effective anti-thyroid than the official hyperthyroid drug carbimazole.
I wonder if this is a reason that Ray Peat and Danny Roddy both need to supplement with thyroid while drinking so much orange juice.
I have personally tried orange juice, but it always leaves me cold. I thought it was the amount of liquid, or the lack of salt, or whatever, but maybe it is just the orange juice itself?
Another study showing the same effect for flavanoids in orange juice:
Inhibition of thyroid peroxidase by dietary flavonoids - PubMed
Flavonoids are widely distributed in plant-derived foods and possess a variety of biological activities including antithyroid effects in experimental animals and humans. A structure-activity study of 13 commonly consumed flavonoids was conducted to evaluate inhibition of thyroid peroxidase...
pubmed.ncbi.nlm.nih.gov
Most flavonoids tested were potent inhibitors of TPO, with IC50 values ranging from 0.6 to 41 microM. Inhibition by the more potent compounds, fisetin, kaempferol, naringenin, and quercetin, which contain a resorcinol moiety, was consistent with mechanism-based inactivation of TPO as previously observed for resorcinol and derivatives. Other flavonoids inhibited TPO by different mechanisms, such as myricetin and naringin, showed noncompetitive inhibition of tyrosine iodination with respect to iodine ion and linear mixed-type inhibition with respect to hydrogen peroxide.