Oral Testosterone Coming To America

[Cameron]

FDA approves new oral testosterone capsule for treatment of men with certain forms of hypogonadism

Previously only really available in Europe. Better then ester based testosterone?

 

[haidut]

FDA approves new oral testosterone capsule for treatment of men with certain forms of hypogonadism

Previously only really available in Europe. Better then ester based testosterone?

It is still an ester - the undecanoate one - despite evidence that pure, unesterified T is absorbed better than any ester, including the undecanoate one. I guess, still better than not having any option at all. It is beyound baffling why FDA would accept that steroids like pregnenolone, DHEA, progesterone, etc are highly bioavailable when administered orally yet somehow steroids like T, DHT, and various other synthetic derivatives are not. The only conclusion I can draw is that FDA purposefully tries to poison the field and steer the public away from oral route, which is easy and accessible for most people. In contrast, when it comes to injections most people depend on doctors to both prescribe and administer them.
Bioavailability of oral testosterone in males. - PubMed - NCBI
"...Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat. Serum testosterone concentration was measured at intervals for up to 6--24 h after the dose. A significant and reproducible rise in serum testosterone level was found after ingestion of free testosterone. Testosterone esterified with undecylenic acid was only effective when administered in arachis oil. The meal increased the bioavailability of the ester, but had hardly any effect on that of the free hormone. It is concluded that bioavailability of oral testosterone can be improved by pharmaceutical means to an extent sufficient to produce adequate blood levels in substitution therapy."

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(74)90216-5/fulltext
"...200 mg. of free testosterone (2-5 µ particles compressed into conventional tablets) produced normal male serum-testosterone levels for 5-7 hours in four subjects without testicular function. Serum-testosterone levels were still at least five times higher than initial values 6-8 hours after tablet ingestion. The clinical effectiveness of oral free testosterone 100 mg. 4 times a day was established in a double-blind trial in five eunuchs. It is concluded that artificial testosterone derivatives have no advantages, either in effect or cost, over oral androgen therapy. Adequate oral doses of natural free testosterone are fully effective in replacing hormonal testicular function."

 

[tallglass13]

@haidut, in a oral testosterone Undeconoate 40mg capsule, how much do think get absorbs orally?

 

[Jing]

@haidut can you put testosterone base powder in capsules and increase blood testosterone levels?

 

[sebastian_r]

Can't have men run around with high T and high DHT and feel and behave like kings.

Limit their options to the crappy esters and let the high E and other side effects negate almost all positive effects of the treatment.

Esters like cypionate and undecanoate seem to have a higher affinity to convert into estradiol and overal treatment with those esters don't tend to lead to great results overal.

Best results yet are achieved currently with daily test prop injections or 2x daily trans-dermal cream on scrotum.

 

[Cameron]

@haidut can you put testosterone base powder in capsules and increase blood testosterone levels?

Yes. It will be absorbed like any hormone

 

[Jing]

Yes. It will be absorbed like any hormone

Interesting, I should be getting testosterone powder sometime soon I'm going to test this out.would dht powder work too?

 

[Cameron]

It is still an ester - the undecanoate one - despite evidence that pure, unesterified T is absorbed better than any ester, including the undecanoate one. I guess, still better than not having any option at all. It is beyound baffling why FDA would accept that steroids like pregnenolone, DHEA, progesterone, etc are highly bioavailable when administered orally yet somehow steroids like T, DHT, and various other synthetic derivatives are not. The only conclusion I can draw is that FDA purposefully tries to poison the field and steer the public away from oral route, which is easy and accessible for most people. In contrast, when it comes to injections most people depend on doctors to both prescribe and administer them.
Bioavailability of oral testosterone in males. - PubMed - NCBI
"...Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat. Serum testosterone concentration was measured at intervals for up to 6--24 h after the dose. A significant and reproducible rise in serum testosterone level was found after ingestion of free testosterone. Testosterone esterified with undecylenic acid was only effective when administered in arachis oil. The meal increased the bioavailability of the ester, but had hardly any effect on that of the free hormone. It is concluded that bioavailability of oral testosterone can be improved by pharmaceutical means to an extent sufficient to produce adequate blood levels in substitution therapy."

Better absorption then ester.. Wow that goes against what everyone tries to tell you. It obviously is political. At this point a company would formulate some type of product for compounding pharmacies to use pure base powder. Unbelievable.

 

[Cameron]

Interesting, I should be getting testosterone powder sometime soon I'm going to test this out.would dht powder work too?

Yes. Even better as it will not aromatize

 

[Cameron]

Interesting, I should be getting testosterone powder sometime soon I'm going to test this out.would dht powder work too?

Is your source overseas and pure testosterone powder product?

 

[haidut]

@haidut can you put testosterone base powder in capsules and increase blood testosterone levels?

According to that study I posted, yes. Capsules, powders, solution, etc should all work.

 

[haidut]

Can't have men run around with high T and high DHT and feel and behave like kings.

Limit their options to the crappy esters and let the high E and other side effects negate almost all positive effects of the treatment.

Esters like cypionate and undecanoate seem to have a higher affinity to convert into estradiol and overal treatment with those esters don't tend to lead to great results overal.

Best results yet are achieved currently with daily test prop injections or 2x daily trans-dermal cream on scrotum.

Esters also potentially have cacrinogenic effects, as Peat mentioned a few times and seems backed up by studies.
DHT Prevents Prostate Cancer And May Even Treat It

 

[Jing]

Is your source overseas and pure testosterone powder product?

From China, raw testosterone base.

 

[Tarmander]

Would oral form junk your liver more then injection? Would TUDCA be needed?

 

[Peater]

Up until now I had no idea oral T was a possibility, I'd always read it got processed by the liver hence steroids being hepatotoxic, as they are designed to survive the process.

 

[haidut]

Would oral form junk your liver more then injection?

Not at all, as long as it is pure T and not an ester. Why would it (when used in physiological doses)? Remember that it was used to cure a majority of cirrhosis cases?
https://raypeatforum.com/community/threads/vitamin-b1-thiamine-and-testosterone-can-cure-liver-cirrhosis.11368/

 

[Cameron]

Not at all, as long as it is pure T and not an ester. Why would it (when used in physiological doses)? Remember that it was used to cure a majority of cirrhosis cases?
https://raypeatforum.com/community/threads/vitamin-b1-thiamine-and-testosterone-can-cure-liver-cirrhosis.11368/

Could oral testosterone in a lower daily dose have a less suppressive mechanism of action. Say years of oral use more similar to the bodies production if one had to stop normal hpta acix function could resort normally rather than high dose injection?

 

[haidut]

Could oral testosterone in a lower daily dose have a less suppressive mechanism of action. Say years of oral use more similar to the bodies production if one had to stop normal hpta acix function could resort normally rather than high dose injection?

That's my (current) understanding. There are other studies with 120mg daily oral doses of T undecanoate and it only suppressed 20% of the people despite absorbing well with a meal. I think T base taken in a single dose similar to DHEA (e.g. no more than 5mg per dose) taken once or twice daily will probably have minor (if any) suppressive effects as it would mimic physiolgical/endogenous T synthesis.

 

[BigYellowLemon]

Is testosterone actually orally bioavailable? Does anyone have any more studies on this?

 

[Cameron]

The concern in the past about pills is that previous formulations caused liver toxicity. This agent works differently. It is absorbed through the lymphatic system, rather than the bloodstream, and therefore bypasses metabolism by the liver, the so-called first-pass effect.