Ondansetron and Receptor Antagonist

Discussion in 'Pharmaceutical Drugs' started by Registration, Sep 6, 2013.

  1. Registration

    Registration Member

    Joined:
    Sep 6, 2013
    Messages:
    5
    Hello,
    I am new here.

    Someone here was recommended Ondansetron for serotonin removal. But, I see that Ondansetron is a 5-HT3 receptor antagonist.

    So wouldn't that drug increase serotonin? The serotonin cannot be used up at the receptor?

    Please do correct me. I have a hard time understanding how all these stuff works.

    Thanks!
     
  2. jaguar43

    jaguar43 Member

    Joined:
    Oct 10, 2012
    Messages:
    1,306

    It still removes serotonin but it's just at a different receptor.


    I have tried a variety of anti-seronotin drugs, I have never tried Ondansetron because of the price and that it only targets the 5-HT3 receptor.

    Ray Peat sent me an email that cyproheptadine is a general serotonin antagonist. Any may be better for overall serotonin. I have Never tried it.

    The Dopamine Agonist Bromocriptine and Lisuride are prolactin inhibitors and useful for high prolactin and estrogen. Bromociptine can cause heart valve fibrosis. Lisuride is safer. I have used both though it really depends on quality. A good bromocriptine can work well but be expensive. Lisuride is pretty good though to much can cause nausea.


    I have used tianeptine and it works well and is safe. But again its about quality.
     
  3. Gabriel

    Gabriel Member

    Joined:
    May 7, 2013
    Messages:
    229
    What positive effects did you notice on these drugs jag and do you still take them?
     
  4. Mittir

    Mittir Member

    Joined:
    Feb 20, 2013
    Messages:
    2,034
    You might find this quote from RP useful

     
  5. jaguar43

    jaguar43 Member

    Joined:
    Oct 10, 2012
    Messages:
    1,306
    I take them once in a while. Lisuride is my favorite. Though the bromocriptine and tianeptine I bought were made in India. They work well.

    With the Lisuride, the prolactin symptoms went away(emotional, depression, sore nipples, ). Headaches went away.

    Tianeptine, overall mood increase, mellow, able to read more than usually.

    The bromocriptine I bought was horrible. It was weak.
     
  6. HDD

    HDD Member

    Joined:
    Nov 1, 2012
    Messages:
    2,011
    jag, did you use these before taking t4/t3? How long did you take them?
     
  7. tropicaldaze

    tropicaldaze Member

    Joined:
    Oct 17, 2013
    Messages:
    6
    Never had my serotonin level measured and I'd be wary of using any prescription drug without a doctor supervising. I am, however, hypothyroid(diagnosed in 1994)and for some reason, meds seemed to have stopped working a few years ago. Winters are hell; cold, depressed and no matter what season, libido has gone south. Now on desiccated@1/4 grain twice a day. What's the dose to shoot for to reduce serotonin? Thanks.
     
  8. jaguar43

    jaguar43 Member

    Joined:
    Oct 10, 2012
    Messages:
    1,306

    I took it while taking cynomel and cynoplus. At the beginning I took 2.5 mg of bromocriptine. I didn't feel anything. after taking it again after six months on cynomel, cynoplus, it was too much. I threw up. I didn't take it consistently because of heart valve problems and nausea. Tianeptine over time decreases its potency. A few days with bromocriptine and lisuride should work.
     
  9. jaguar43

    jaguar43 Member

    Joined:
    Oct 10, 2012
    Messages:
    1,306
    I would disagree. Most doctors don't understand the long term effects of most medications. Plus they only prescribe expensive medications.
     
  10. jyb

    jyb Member

    Joined:
    Nov 9, 2012
    Messages:
    2,751
    Location:
    UK
    Based on personal experience, I'd be wary of using most common prescription drugs with a medical doctor supervising.
     
Loading...