Ocular progesterone administration may treat eye, brain, and mental illness

loess

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@haidut, while discussing this study in the latest episode of Generative Energy, you mentioned niacinamide as a potentiator of steroids in water, and suggested making a 2% solution of niacinamide, then adding progesterone to it. Is Progesterone soluble enough in water for this to work, or must it be suspended in a lipid like MCT or olive oil? Would the following recipe work for practical purposes in administering an ocular solution of progesterone and niacinamide?:

1) Make a 2% solution of niacinamide in distilled water using niacinamide powder.
2) Add Progesterone (micronized powder, USP grade) to 2% niacinamide solution.
3) Heat and stir until fully dissolved.
4) Fill eye dropper with solution.
5) Administer in eye.

I'm interested in experimenting with this to help with complications from neurological tick-borne bacterial infections (Bartonella, Lyme, and Babesia in particular) that have resulted in persistent uvetis, and to attempt to use the eye as a pathway for the progesterone and niacinamide to enter the CNS/brain...
 

loess

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Anyone have thoughts on this?
 

catharsis

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@loess Progesterone has a log P value of about 3.9 which means it is very hydrophobic (higher numbers means more hydrophobicity, and vice-versa). The more hydrophobic compounds typically need some kind of modification to make it solubilized: either emulsifiers, different solvents, or some chemical modification (more hydrogen bonds or having a hydrophilic tail like sulfated steroids or nucleotides with a triphosphate tail).

Haidut mentioned that having esterified steroids would metabolize in the eye so, if you can source a clean sulfated pregnenolone, DHEA, or progesterone source, try that. Haidut also used acetoacetate and ethyl pyruvate in some of his Idealabs products and they also work as solvents. I am not sure how irritating they can be to the eye but you can check the MSDS on them. If you are a crazy enough scientist and believe experience is the best teacher (or data), you should look for those and maybe try that as an additional solvent to distilled water.
 

loess

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@catharsis Thanks so much, that's all really helpful information.
 

BrianF

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Did anyone ever come up with a solution to this? Asking for a friend. A blind friend.
 

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