Nutrients in excess, glucolipotoxicity and ROS

[Amazoniac]

http://iovs.arvojournals.org/data/Journ ... ultClick=1
The study suggests that nutrients in excess synergistically create much more damage by exaggerating ROS production.

 

[Amazoniac]

The balance crowd quiver..

 

[Such_Saturation]

Tens of thousands of publications describe the pathogenic effects of sugar. To prove their point, they grow cells in a culture dish, and find that when they are exposed to excess glucose, often 5 times the normal amount, they deteriorate. In the artificial conditions of cell culture, the oversupply of glucose causes lactic acid to accumulate, leading to toxic effects. But in the organism, the hyperglycemia is compensating for a sensed deficiency of glucose, a need for more energy.

If diabetes means that cells can't absorb or metabolize glucose, then any cellular function that requires glucose will be impaired, despite the presence of glucose in the blood. It is the intracellular absence of glucose which is problematic, rather than its extracellular excess.
Neuroglycopenia (or neuroglucopenia) or intracellular glycopenia refers to the deficit of glucose in cells. When the brain senses a lack of glucose, nerves are activated to increase the amount of glucose in the blood, to correct the problem. As long as the brain senses the need for more glucose, the regulatory systems will make the adjustments to the blood glucose level.

 

[Amazoniac]

Thank you Such_, I haven't read that before. Great!