November 19, 2019 One Radio Network Interview

[yerrag]

I think the tank is the only reliable way unless you live by a spring known to be rich in carbonic acid and can bathe in it....

I bought a CO2 bath from Steve at Carbogenetics 2 years ago. Have the whole set up already but haven't really used it. It was hard to use by myself as you need a buddy to be there in case of an emergency situation. Last time I was in touch with Steve he's developed a space suit like contraption that's more practical and he says he was testing it out with a lab at Stanford. I'll have to check with him on his progress.

 

[Inaut]

I wanted to buy a sweat suit (ones fighters wear to lose water weight) but I want one with tight seals on arms and legs....

I was bagging my waste previously but wanted a full body effect...

 

[lampofred]

It seems so silly that we try all these things, PUFA restriction, blood donation, drinking gallons of milk, taking hormones, now even buying tanks, all just to increase CO2 when it is something we produce all the time. Why don't our brains just lower our breathing rate lmao.

 

[yerrag]

I wanted to buy a sweat suit (ones fighters wear to lose water weight) but I want one with tight seals on arms and legs....

I was bagging my waste previously but wanted a full body effect...

That's what Steve's space suit looks like!

It seems so silly that we try all these things, PUFA restriction, blood donation, drinking gallons of milk, taking hormones, now even buying tanks, all just to increase CO2 when it is something we produce all the time. Why don't our brains just lower our breathing rate lmao.

I didn't need it. My body doesn't need that intervention. I bought it for my mom, as she may have benefited from that kind of help, but it was really impractical for her to don a space suit like contraption. Still, I'd like to try it. Ray Peat talked about this guy whose body got exposed to a CO2 chamber and he gave off a lot of steam. A lot of unnecessary water in the tissues coming out. I don't remember what his sickness was, but it sure did a lot of good.

 

[lampofred]

That's what Steve's space suit looks like!

I didn't need it. My body doesn't need that intervention. I bought it for my mom, as she may have benefited from that kind of help, but it was really impractical for her to don a space suit like contraption. Still, I'd like to try it. Ray Peat talked about this guy whose body got exposed to a CO2 chamber and he gave off a lot of steam. A lot of unnecessary water in the tissues coming out. I don't remember what his sickness was, but it sure did a lot of good.

I was talking mostly about myself and in a really general sense about anyone with metabolic issues, not directed at you at all.

 

[yerrag]

I was talking mostly about myself and in a really general sense about anyone with metabolic issues, not directed at you at all.

I didn't mean to imply that. And I agree with you. Give your body what it needs, and it'll be fine.

 

[boris]

It seems so silly that we try all these things, PUFA restriction, blood donation, drinking gallons of milk, taking hormones, now even buying tanks, all just to increase CO2 when it is something we produce all the time. Why don't our brains just lower our breathing rate lmao.

I think the reason for overbreathing is that the body is already messed up and confused. Just reverse engineer why overbreathing happens, several broken factors come into play before overbreathing even starts and keeps the destructive cycle going.

 

[cdg]

Ray's talked about albumin, and how albumin attracts sodium. With low albumin, there would not be a lot of sodium attracted to it, and with the albumin pool being low in my blood, the sodium pool would also be low. The volume of plasma would be low as well, given that only a limited amount of water can form plasma. This is because the amount of water in plasma can't be more than what constitutes an isotonic saline solution in plasma, which is a concentration of 0.9% (and allowable tight variation from it).

So how to you increase albumin ??

 

[yerrag]

So how to you increase albumin ??

I'm eating more meat, more than my usual. Get more sleep to let my liver produce more albumin. Reducing endotoxin loads from food (I suspect my source of milk has lots of endotoxin for example, so I'm stopping it for now) to keep albumin from being excreted along with the endotoxin which albumin binds to. And taking taurine, which keeps albumin from being excreted along with urine, which is happening with my urine.

 

[Lejeboca]

So how to you increase albumin ??

Found this curious (see the PDF attached):
Caso G, Feiner J, Mileva I, et al. Response of albumin synthesis to oral nutrients in young and elderly subjects. Am J Clin Nutr 2007;85:446–51

From Discussion:
The present study showed that in the post absorptive state the
total amount of albumin synthesized per day (ie, ASR) in elderly
subjects was ~25% lower than that in the young subjects (Figure
2). This decrease in ASR arose primarily from the smaller mass
of albumin in the elderly subjects rather than from a decrease in
the fractional synthesis rate of albumin (the proportion of the
intravascular pool of albumin which is renewed each day). De-
spite the lower ASR, the response of albumin synthesis in elderly
subjects to the ingestion of oral nutrients was comparable to the
response in young subjects. Both albumin FSR and ASR were
increased by 30 – 40% compared with the consumption of water
only. Moreover, in both young and elderly subjects, ingestion of
the protein component of the meal alone induced rates of albumin
synthesis comparable to those achieved with the complete (car-
bohydrate, fat, and protein) meal (Figures 1 and 2).


However, because the
basal amounts of albumin produced per day (fasting ASR) are
lower in older subjects, the total amounts of albumin synthesized
in response to food intake were smaller in the elderly than in the
young subjects. This suggests the possibility of a smaller albumin
reserve available to elderly subjects.


And from the Intro:
Albumin synthesis by the liver is acutely stimulated by feeding
(1–3), and it has been suggested that increased postprandial al-
bumin synthesis may serve as temporary storage for dietary es-
sential amino acids, thus preventing their oxidative loss (1, 3).
Albumin catabolism during the postabsorptive period may then
release essential amino acids, making them available to muscle
and other tissues to maintain protein synthesis. The increase in
the albumin synthesis rate after a meal therefore may have the
important physiologic function of preventing oxidation of essen-
tial amino acids from the diet and may have an important role in
the long-term maintenance of body protein and muscle mass.
albumin synthesis rate after a meal therefore may have the


N.B. prompted by @Mito thread A Word Of Caution Against Excessive Protein Intake

@yerrag

 

[yerrag]

Found this curious (see the PDF attached):
Caso G, Feiner J, Mileva I, et al. Response of albumin synthesis to oral nutrients in young and elderly subjects. Am J Clin Nutr 2007;85:446–51

From Discussion:
The present study showed that in the post absorptive state the
total amount of albumin synthesized per day (ie, ASR) in elderly
subjects was ~25% lower than that in the young subjects (Figure
2). This decrease in ASR arose primarily from the smaller mass
of albumin in the elderly subjects rather than from a decrease in
the fractional synthesis rate of albumin (the proportion of the
intravascular pool of albumin which is renewed each day). De-
spite the lower ASR, the response of albumin synthesis in elderly
subjects to the ingestion of oral nutrients was comparable to the
response in young subjects. Both albumin FSR and ASR were
increased by 30 – 40% compared with the consumption of water
only. Moreover, in both young and elderly subjects, ingestion of
the protein component of the meal alone induced rates of albumin
synthesis comparable to those achieved with the complete (car-
bohydrate, fat, and protein) meal (Figures 1 and 2).


However, because the
basal amounts of albumin produced per day (fasting ASR) are
lower in older subjects, the total amounts of albumin synthesized
in response to food intake were smaller in the elderly than in the
young subjects. This suggests the possibility of a smaller albumin
reserve available to elderly subjects.


And from the Intro:
Albumin synthesis by the liver is acutely stimulated by feeding
(1–3), and it has been suggested that increased postprandial al-
bumin synthesis may serve as temporary storage for dietary es-
sential amino acids, thus preventing their oxidative loss (1, 3).
Albumin catabolism during the postabsorptive period may then
release essential amino acids, making them available to muscle
and other tissues to maintain protein synthesis. The increase in
the albumin synthesis rate after a meal therefore may have the
important physiologic function of preventing oxidation of essen-
tial amino acids from the diet and may have an important role in
the long-term maintenance of body protein and muscle mass.
albumin synthesis rate after a meal therefore may have the


N.B. prompted by @Mito thread A Word Of Caution Against Excessive Protein Intake

@yerrag

Thanks. This means that it won't take long to build up albumin in serum, as long as I'm not using up albumin so quickly. Aside from albumin binding to LPS and being excreted, it's also an antioxidant and could be used up in high oxidative stress conditions, such as in phagocytosis of bacteria by neutrophls, where ROS produced has spillover effects that need antioxidants to counter. Uric acid and albumin are endogenous antioxidants, and their use can be lessened by vitamin C supplementation.

 

[cdg]

I'm eating more meat, more than my usual. Get more sleep to let my liver produce more albumin. Reducing endotoxin loads from food (I suspect my source of milk has lots of endotoxin for example, so I'm stopping it for now) to keep albumin from being excreted along with the endotoxin which albumin binds to. And taking taurine, which keeps albumin from being excreted along with urine, which is happening with my urine.

Thanks both yerrag & Lejeboca.