Nitrous Oxide (N2O) Prevents Suicidal Behavior, Reverses Learned Helplessness

[GAF]

I will ask my psychiatrist

From reading up and YouTube, probably the most harmless substance he has ever prescribed. Not to mention, the cheapest and not to mention the funniest.

 

[Koveras]

First, please note that this study is about nitrous oxide (N2O) and not nitric oxide (NO). There is a huge difference in effects despite the minor difference in chemical structure. Peat has written about both - the benefits of the former and the dangers of the latter. N2O is commonly known as laughing gas and is widely used in surgical procedures, as well as recreationally due to its rapid antidepressant and dissociative effects. N2O is a known NMDA and 5-HT3 antagonist, as well as GABA and glycine agonist. It is perhaps its extremely rapid antidepressant effects (much quicker onset than even ketamine) that is behind the beneficial effects the study below is based on. As many of you know, there is no currently known effective treatment for suicidal behavior / ideation, except possibly electroconvulsive therapy. N2O has shown a lot of promise in animal studies and according to the authors of the study below, it should be able to prevent suicide in humans as well. Furthermore, as the authors themselves state, suicidal behavior is an extreme form of learned helplessness and N2O can quickly reverse such a state. As a side note, N2O is a strong oxidizing agent and as such has positive effects on the redox balance of the organism including NAD/NADH ratio, CO2 levels, and of course thyroid function. So, the metabolic foundation in depression, learned helplessness and suicide is highly visible once again.

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. - PubMed - NCBI
New Study Finds Laughing Gas Could Help Prevent Suicide - Thriveworks
"...And while there is no one cause for suicide, mental illness is often involved—depression, for example, is most commonly associated with suicide, which is typically undiagnosed or untreated in these individuals. This condition, left untreated (as well as many others) increases one’s risk for suicide. There are currently no treatments specifically approved to stop suicidal thoughts. Instead, identifying and treating underlying mental illnesses as well as coping with any stressors are essential to reducing the risk. This, however, may soon be joined by an unlikely ally: laughing gas. Researchers at Washington University School of Medicine in St. Louis are studying the potential use of laughing gas (nitrous oxide) as an effective treatment method in patients hospitalized for suicidal thoughts. More specifically, the study is exploring whether laughing gas may speed up recovery and even reduce one’s risk of suicide."

"...Charles R. Conway, MD, a professor of psychiatry, and Peter Nagele, MD, an associate professor of anesthesiology, head the study, as they have been studying whether the substance—known to lessen pain and anxiety in dental patients—could provide relief to depressed individuals. And the fact that 85% of suicide attempts are made by clinically depressed individuals has inspired them to expand their research and investigate whether laughing gas may help suicidal patients as well."

“Suicide attempts and suicidal thinking often stem from an individual’s belief that there’s no way out of a situation other than ending one’s life,” explained Conway. “We think nitrous oxide might help patients break out of that mindset and realize they do have options.” While as many as one-third of patients with depression don’t respond to existing treatments, Conway’s research team is confident that laughing gas will finally provide relief, thanks to an initial study that revealed two-thirds of depressed participants treated with the nitrous oxide saw improvement in their symptoms."

"...Most existing antidepressants work by targeting norepinephrine and serotonin receptors; this, however, can take weeks to actually alleviate one’s symptoms. Nitrous oxide, on the other hand, interacts with another kind of receptor (NMDA glutamate) and can improve symptoms within hours. Furthermore, it has minimal side effects: “Nitrous oxide may very quickly improve depression in these patients. The gas has very few side effects because it leaves the body very quickly once people stop breathing it,” explained Nagele. “However, it appears from our previous research that the antidepressant effects of nitrous oxide may linger in the brain long after the drug is out of the body.”

No wonder it's antidepressant

Also subject #1 ....definitely not depressed.

The effects of nitrous oxide and naloxone on orgasm in human females: A preliminary report

 

[TreasureVibe]

Cancer Is A Nitrogen Deficiency, Cancer Cell = Cell In Fermentation, Dr. Otto Warburg Was Right

 

[stsfut]

Is this why guiness makes me so happy?

 

[Evgenius]

Anyone found some easy and legal way to supplement this ?

 

[GAF]

Anyone found some easy and legal way to supplement this ?

amazon.com and the dollar store

 

[energyandstruct]

First, please note that this study is about nitrous oxide (N2O) and not nitric oxide (NO). There is a huge difference in effects despite the minor difference in chemical structure. Peat has written about both - the benefits of the former and the dangers of the latter. N2O is commonly known as laughing gas and is widely used in surgical procedures, as well as recreationally due to its rapid antidepressant and dissociative effects. N2O is a known NMDA and 5-HT3 antagonist, as well as GABA and glycine agonist. It is perhaps its extremely rapid antidepressant effects (much quicker onset than even ketamine) that is behind the beneficial effects the study below is based on. As many of you know, there is no currently known effective treatment for suicidal behavior / ideation, except possibly electroconvulsive therapy. N2O has shown a lot of promise in animal studies and according to the authors of the study below, it should be able to prevent suicide in humans as well. Furthermore, as the authors themselves state, suicidal behavior is an extreme form of learned helplessness and N2O can quickly reverse such a state. As a side note, N2O is a strong oxidizing agent and as such has positive effects on the redox balance of the organism including NAD/NADH ratio, CO2 levels, and of course thyroid function. So, the metabolic foundation in depression, learned helplessness and suicide is highly visible once again.

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. - PubMed - NCBI
New Study Finds Laughing Gas Could Help Prevent Suicide - Thriveworks
"...And while there is no one cause for suicide, mental illness is often involved—depression, for example, is most commonly associated with suicide, which is typically undiagnosed or untreated in these individuals. This condition, left untreated (as well as many others) increases one’s risk for suicide. There are currently no treatments specifically approved to stop suicidal thoughts. Instead, identifying and treating underlying mental illnesses as well as coping with any stressors are essential to reducing the risk. This, however, may soon be joined by an unlikely ally: laughing gas. Researchers at Washington University School of Medicine in St. Louis are studying the potential use of laughing gas (nitrous oxide) as an effective treatment method in patients hospitalized for suicidal thoughts. More specifically, the study is exploring whether laughing gas may speed up recovery and even reduce one’s risk of suicide."

"...Charles R. Conway, MD, a professor of psychiatry, and Peter Nagele, MD, an associate professor of anesthesiology, head the study, as they have been studying whether the substance—known to lessen pain and anxiety in dental patients—could provide relief to depressed individuals. And the fact that 85% of suicide attempts are made by clinically depressed individuals has inspired them to expand their research and investigate whether laughing gas may help suicidal patients as well."

“Suicide attempts and suicidal thinking often stem from an individual’s belief that there’s no way out of a situation other than ending one’s life,” explained Conway. “We think nitrous oxide might help patients break out of that mindset and realize they do have options.” While as many as one-third of patients with depression don’t respond to existing treatments, Conway’s research team is confident that laughing gas will finally provide relief, thanks to an initial study that revealed two-thirds of depressed participants treated with the nitrous oxide saw improvement in their symptoms."

"...Most existing antidepressants work by targeting norepinephrine and serotonin receptors; this, however, can take weeks to actually alleviate one’s symptoms. Nitrous oxide, on the other hand, interacts with another kind of receptor (NMDA glutamate) and can improve symptoms within hours. Furthermore, it has minimal side effects: “Nitrous oxide may very quickly improve depression in these patients. The gas has very few side effects because it leaves the body very quickly once people stop breathing it,” explained Nagele. “However, it appears from our previous research that the antidepressant effects of nitrous oxide may linger in the brain long after the drug is out of the body.”

Nitrous oxide seems beneficial to me, but ray has concerns about it raising nitric oxide. And it can also cause neuropathy by depleting b12.


Hmm. I’m curious about the anaesthetic noble gases, like xenon, that ray has said are expensive but good. Does anyone know where to obtain? There’s also carbogen

 

[energyandstruct]

He mentioned it in one of his articles and I think 3 of his newsletters. Adamantane has a very similar effects on structuring water and is dissociative and possibly sedative in higher doses, much like N2O. It is also a known NMDA antagonist, same as N2O, so the parallels in effects is not a coincidence.
Unsaturated fatty acids: Nutritionally essential, or toxic?
"...For example, a deficiency of the so-called essential fatty acids, EFA, makes animals more sensitive to some anesthetics, and more resistant to others. It makes them resistant to the anesthetics that act by promoting the actions of serotonin, but it prolongs the effects of those that don't act through serotonin, and these are the anesthetics such as xenon and nitrous oxide, that apparently act by stabilizing the structure of water, as described by Linus Pauling. Progesterone and the saturated fats seem to act partly through the stabilizing of cell water, and estrogen and the PUFA have opposing effects, creating cellular excitation while interfering with the stable cellular water structure."

im going to ask ray about this Bc when I asked if he thought nitrous oxide was beneficial he said no Bc it raises nitric oxide

 

[Tristan Loscha]

Nitrous oxide seems beneficial to me, but ray has concerns about it raising nitric oxide. And it can also cause neuropathy by depleting b12.


Hmm. I’m curious about the anaesthetic noble gases, like xenon, that ray has said are expensive but good. Does anyone know where to obtain? There’s also carbogen

+1

Especially the B12.
Cobalamins Cobalt will irreversibly change conformation,loss of one-carbon
metabolism ensues.Peat is out of his mind with Xenon also.
The Neuropathy will be a central one,like MS.
It will give you most serious symptoms,include loss of brainfunction.
Dont do it Kids.

 

[ReSTART]

+1

Especially the B12.
Cobalamins Cobalt will irreversibly change conformation,loss of one-carbon
metabolism ensues.Peat is out of his mind with Xenon also.
The Neuropathy will be a central one,like MS.
It will give you most serious symptoms,include loss of brainfunction.
Dont do it Kids.

It only inhibits B12 for 3-4 days. If you're not B12 deficient and only use nitrous oxide once every month or so, you should be okay.

 

[MyUsernameHere]

Anyone found some easy and legal way to supplement this ?

Sure: Amazon product ASIN B000COXD3K

(NITROUS OXIDE HISSES)

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[Tristan Loscha]

It only inhibits B12 for 3-4 days. If you're not B12 deficient and only use nitrous oxide once every month or so, you should be okay.

It doesn't inhibit B12, it modifies it irreversibly. You will get B12 deficient in your CNS.

 

[ReSTART]

Yes it oxidizes the cobalt irreversibly. They've used it for anesthesia for literally centuries and the only case reports of people being hurt from nitrous oxide in journals, that I can find, are from people who used it literally everyday.

If you can find any reports of harm from people using it intermittently, please post it.

 

[Tristan Loscha]

N2O is quite dangerous and neurotoxic, and chronic low grade degeneration is underresearched and underreported/deemed as caused by surgery/confounding illness etc.

 

[Yody]

Yes it oxidizes the cobalt irreversibly. They've used it for anesthesia for literally centuries and the only case reports of people being hurt from nitrous oxide in journals, that I can find, are from people who used it literally everyday.

If you can find any reports of harm from people using it intermittently, please post it.

Do you know/suspect if it oxidizes ALL cobalt, or just some noteworthy percentage?

 

[Rick K]

First, please note that this study is about nitrous oxide (N2O) and not nitric oxide (NO). There is a huge difference in effects despite the minor difference in chemical structure. Peat has written about both - the benefits of the former and the dangers of the latter. N2O is commonly known as laughing gas and is widely used in surgical procedures, as well as recreationally due to its rapid antidepressant and dissociative effects. N2O is a known NMDA and 5-HT3 antagonist, as well as GABA and glycine agonist. It is perhaps its extremely rapid antidepressant effects (much quicker onset than even ketamine) that is behind the beneficial effects the study below is based on. As many of you know, there is no currently known effective treatment for suicidal behavior / ideation, except possibly electroconvulsive therapy. N2O has shown a lot of promise in animal studies and according to the authors of the study below, it should be able to prevent suicide in humans as well. Furthermore, as the authors themselves state, suicidal behavior is an extreme form of learned helplessness and N2O can quickly reverse such a state. As a side note, N2O is a strong oxidizing agent and as such has positive effects on the redox balance of the organism including NAD/NADH ratio, CO2 levels, and of course thyroid function. So, the metabolic foundation in depression, learned helplessness and suicide is highly visible once again.

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. - PubMed - NCBI
New Study Finds Laughing Gas Could Help Prevent Suicide - Thriveworks
"...And while there is no one cause for suicide, mental illness is often involved—depression, for example, is most commonly associated with suicide, which is typically undiagnosed or untreated in these individuals. This condition, left untreated (as well as many others) increases one’s risk for suicide. There are currently no treatments specifically approved to stop suicidal thoughts. Instead, identifying and treating underlying mental illnesses as well as coping with any stressors are essential to reducing the risk. This, however, may soon be joined by an unlikely ally: laughing gas. Researchers at Washington University School of Medicine in St. Louis are studying the potential use of laughing gas (nitrous oxide) as an effective treatment method in patients hospitalized for suicidal thoughts. More specifically, the study is exploring whether laughing gas may speed up recovery and even reduce one’s risk of suicide."

"...Charles R. Conway, MD, a professor of psychiatry, and Peter Nagele, MD, an associate professor of anesthesiology, head the study, as they have been studying whether the substance—known to lessen pain and anxiety in dental patients—could provide relief to depressed individuals. And the fact that 85% of suicide attempts are made by clinically depressed individuals has inspired them to expand their research and investigate whether laughing gas may help suicidal patients as well."

“Suicide attempts and suicidal thinking often stem from an individual’s belief that there’s no way out of a situation other than ending one’s life,” explained Conway. “We think nitrous oxide might help patients break out of that mindset and realize they do have options.” While as many as one-third of patients with depression don’t respond to existing treatments, Conway’s research team is confident that laughing gas will finally provide relief, thanks to an initial study that revealed two-thirds of depressed participants treated with the nitrous oxide saw improvement in their symptoms."

"...Most existing antidepressants work by targeting norepinephrine and serotonin receptors; this, however, can take weeks to actually alleviate one’s symptoms. Nitrous oxide, on the other hand, interacts with another kind of receptor (NMDA glutamate) and can improve symptoms within hours. Furthermore, it has minimal side effects: “Nitrous oxide may very quickly improve depression in these patients. The gas has very few side effects because it leaves the body very quickly once people stop breathing it,” explained Nagele. “However, it appears from our previous research that the antidepressant effects of nitrous oxide may linger in the brain long after the drug is out of the body.”

One more reason to go to the dentist

 

[ReSTART]

Do you know/suspect if it oxidizes ALL cobalt, or just some noteworthy percentage?

The dose required for therapeutic effect will oxidize enough to be harmful, if taken chronically. That's why all the studies have at least a one month cooling-off period.

 

[Yody]

View: https://youtu.be/zH1B0uLr9VA

 

[schultz]

No wonder it's antidepressant

Also subject #1 ....definitely not depressed.

The effects of nitrous oxide and naloxone on orgasm in human females: A preliminary report

View attachment 7560

Interesting paper to read. The naloxone part especially, which had seemingly contradictory effects at different times or dosage. The authors admit they don't understand why since their theory was the nitrous oxide worked on the opiate system. Of course, it's a small study with a messy design, but I always enjoy reading studies like this more TBH.

Patient 1 was able to orgasm merely by fantasizing. Impressive!

 

[agriff]

Israeli Study Links Nitric Oxide to Autism

Israel has done a lot of research and work on autism and how it effects children and their families. The country continually attempts to help those with the developmental disorder deal with everyday life. Israel has a national autism data base as a resource to study autism risk factors...

www.trialsitenews.com