Nitrous Oxide (N2O) Prevents Suicidal Behavior, Reverses Learned Helplessness

[Broken man]

IdeaLabs SmileOn

Lol... +1

 

[paymanz]

Can you please reference to where Peat talks favorably about nitrous oxide?

Yes thats interesting to hear from peat, maybe light search engine could find it?!

I remember I was in a health food store about 2 month ago chatting with this couple. This guy, all of a sudden, was really intense. He said, "You know, all this stuff...it is all ***t compared to Nitrous Oxide." I looked at him a bit oddly and said "Laughing gas?" He said "yes! I was close to death, my heart was almost done, my blood pressure was way out of whack, and I started breathing it in everyday. Now I am strong and have perfect blood pressure. My ticker is still going too!" I will admit I thought he was a bit crazy.

Thats interesting!!

Those pharmalogical effects could easily be achieved from combining a NMDA antagonist with anple amounts of gelatin (glycine agonist), niacinamide/MB (NAD/NADH ratio) and thyroid/metabolically enhanced diet/lifestyle (CO2)?

Yes i was thinking about MB too, would like to know how differently they work on cells.

 

[paymanz]

Its crazy, this stuff is a world itself, i wondering how we missed it! LOL

Im interest to know about dosage..

 

[firebreather]

Interested to see how one would try using.

Here's a deal on amazon for 50 chargers.

https://www.amazon.com/Creamright-U...d=1512060766&sr=8-2&keywords=whipits+chargers

 

[alywest]

The Ray Peat Forum could throw a great party...even without alcohol

 

[dfspcc20]

I've recently learned that n20 can be used for women in labor to reduce pain and help them feel comfortable (which is almost impossible in a hospital environment).
It was offered for my wife's 3rd (current) pregnancy. I'm not sure why it wasn't offered for the previous 2; maybe it's a new thing or OB/midwife's preference or what.
Only real downside about it I found is that it can deplete certain B vitamins if used for an extended period of time.

 

[haidut]

Can you please reference to where Peat talks favorably about nitrous oxide?

He mentioned it in one of his articles and I think 3 of his newsletters. Adamantane has a very similar effects on structuring water and is dissociative and possibly sedative in higher doses, much like N2O. It is also a known NMDA antagonist, same as N2O, so the parallels in effects is not a coincidence.
Unsaturated fatty acids: Nutritionally essential, or toxic?
"...For example, a deficiency of the so-called essential fatty acids, EFA, makes animals more sensitive to some anesthetics, and more resistant to others. It makes them resistant to the anesthetics that act by promoting the actions of serotonin, but it prolongs the effects of those that don't act through serotonin, and these are the anesthetics such as xenon and nitrous oxide, that apparently act by stabilizing the structure of water, as described by Linus Pauling. Progesterone and the saturated fats seem to act partly through the stabilizing of cell water, and estrogen and the PUFA have opposing effects, creating cellular excitation while interfering with the stable cellular water structure."

 

[alywest]

I've recently learned that n20 can be used for women in labor to reduce pain and help them feel comfortable (which is almost impossible in a hospital environment).
It was offered for my wife's 3rd (current) pregnancy. I'm not sure why it wasn't offered for the previous 2; maybe it's a new thing or OB/midwife's preference or what.
Only real downside about it I found is that it can deplete certain B vitamins if used for an extended period of time.

That could work out if you brought your own B vitamin supps, like a smoothie with brewer's yeast. I wonder if they would allow it. I guess they would really only let me have Jello and clear juices now that I think about it. Make your own jello with brewer's yeast? Labor desserts: the newest trend on RPF.

 

[bodacious]

Nitrous oxide (laughing gas) — a cause of neurotoxicity

 

[GAF]

nitrous oxide (N2O)

Anyone tried this to help someone get through benzo withdrawal?

 

[Mountain]

Nitrous oxide (laughing gas) — a cause of neurotoxicity

What's the purpose of the link?
Says that the guy was doing 240 whippets per day for a few weeks (after years of cocaine and alcohol abuse) leading up to him being hospitalized.

 

[bodacious]

What's the purpose of the link?
Says that the guy was doing 240 whippets per day for a few weeks (after years of cocaine and alcohol abuse) leading up to him being hospitalized.

I was warned about it years ago by an anaesthesiologist.

NOS is a neurotoxin, so do be careful.

 

[LUH 3417]

I've recently learned that n20 can be used for women in labor to reduce pain and help them feel comfortable (which is almost impossible in a hospital environment).
It was offered for my wife's 3rd (current) pregnancy. I'm not sure why it wasn't offered for the previous 2; maybe it's a new thing or OB/midwife's preference or what.
Only real downside about it I found is that it can deplete certain B vitamins if used for an extended period of time.

Yea I know they use it at the birth center I worked at but I've never seen it on my clinical rotations on the LD floors. I think the evidence for its efficacy is pretty new so maybe hospitals have been slow to implement. Also I imagine the reimbursement on epidurals to be way more $$$$ for the hospital.

 

[Zpol]

The question is where we get N2O from

Attend rave parties or befriend a dentist are the only ways I know.

What do ovulating women breathe out, NO or N2O?

LOL! It certainly is the most 'excitable' time for a lady person.

 

[LUH 3417]

Attend rave parties or befriend a dentist are the only ways I know.



LOL! It certainly is the most 'excitable' time for a lady person.

You can buy tanks at head shops in large US cities

 

[Zpol]

You can buy tanks at head shops in large US cities

Thanks! There's a few head shops near me that I will look into. I'm going to do some more research first before I do it as a therapy.

 

[GAF]

You can buy N2O cartridges and a whipped cream maker on Amazon and balloons at the dollar store and YouTube has videos on breathing the stuff in.

 

[Frankdee20]

First, please note that this study is about nitrous oxide (N2O) and not nitric oxide (NO). There is a huge difference in effects despite the minor difference in chemical structure. Peat has written about both - the benefits of the former and the dangers of the latter. N2O is commonly known as laughing gas and is widely used in surgical procedures, as well as recreationally due to its rapid antidepressant and dissociative effects. N2O is a known NMDA and 5-HT3 antagonist, as well as GABA and glycine agonist. It is perhaps its extremely rapid antidepressant effects (much quicker onset than even ketamine) that is behind the beneficial effects the study below is based on. As many of you know, there is no currently known effective treatment for suicidal behavior / ideation, except possibly electroconvulsive therapy. N2O has shown a lot of promise in animal studies and according to the authors of the study below, it should be able to prevent suicide in humans as well. Furthermore, as the authors themselves state, suicidal behavior is an extreme form of learned helplessness and N2O can quickly reverse such a state. As a side note, N2O is a strong oxidizing agent and as such has positive effects on the redox balance of the organism including NAD/NADH ratio, CO2 levels, and of course thyroid function. So, the metabolic foundation in depression, learned helplessness and suicide is highly visible once again.

Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. - PubMed - NCBI
New Study Finds Laughing Gas Could Help Prevent Suicide - Thriveworks
"...And while there is no one cause for suicide, mental illness is often involved—depression, for example, is most commonly associated with suicide, which is typically undiagnosed or untreated in these individuals. This condition, left untreated (as well as many others) increases one’s risk for suicide. There are currently no treatments specifically approved to stop suicidal thoughts. Instead, identifying and treating underlying mental illnesses as well as coping with any stressors are essential to reducing the risk. This, however, may soon be joined by an unlikely ally: laughing gas. Researchers at Washington University School of Medicine in St. Louis are studying the potential use of laughing gas (nitrous oxide) as an effective treatment method in patients hospitalized for suicidal thoughts. More specifically, the study is exploring whether laughing gas may speed up recovery and even reduce one’s risk of suicide."

"...Charles R. Conway, MD, a professor of psychiatry, and Peter Nagele, MD, an associate professor of anesthesiology, head the study, as they have been studying whether the substance—known to lessen pain and anxiety in dental patients—could provide relief to depressed individuals. And the fact that 85% of suicide attempts are made by clinically depressed individuals has inspired them to expand their research and investigate whether laughing gas may help suicidal patients as well."

“Suicide attempts and suicidal thinking often stem from an individual’s belief that there’s no way out of a situation other than ending one’s life,” explained Conway. “We think nitrous oxide might help patients break out of that mindset and realize they do have options.” While as many as one-third of patients with depression don’t respond to existing treatments, Conway’s research team is confident that laughing gas will finally provide relief, thanks to an initial study that revealed two-thirds of depressed participants treated with the nitrous oxide saw improvement in their symptoms."

"...Most existing antidepressants work by targeting norepinephrine and serotonin receptors; this, however, can take weeks to actually alleviate one’s symptoms. Nitrous oxide, on the other hand, interacts with another kind of receptor (NMDA glutamate) and can improve symptoms within hours. Furthermore, it has minimal side effects: “Nitrous oxide may very quickly improve depression in these patients. The gas has very few side effects because it leaves the body very quickly once people stop breathing it,” explained Nagele. “However, it appears from our previous research that the antidepressant effects of nitrous oxide may linger in the brain long after the drug is out of the body.”

How does a N2o make that much difference than simply nitric Oxide ?

 

[GAF]

H2O is different than HO in so many ways. HO HO HO, Merry Christmas.

 

[CoconutEffect]

Anyone tried this to help someone get through benzo withdrawal?

I will ask my psychiatrist as he’s very interested in using this in his practice last we spoke