Nitric Oxide, DHT, H2 Antagonists

[LCohen]

1. There are some claims that Cimetidine (H2 Antagonist) grows hair. It's attributed to anti-androgenic activity but see what haidut shared.

(Just like Famotidine and Ranitidine) Cimetidine shows anti-oxidant activity. It also scavenges nitric oxide. Maybe that anti-oxidant, anti-NO activity cause re-growth ?

2. And here a different study. Says that DHT (but not plain testosterone) promotes NO.

Nitric oxide in the human hair follicle

...This biomolecule is apparently formed by the endothelial isoform of nitric oxide synthase, which was detected at the mRNA and protein levels. Remarkably, basal NO level was enhanced threefold by stimulating dermal papilla cells with 5alpha-dihydrotestosterone (DHT) but not with testosterone. Addition of N-[3-(aminomethyl)benzyl]acetamidine (1400W), a highly selective inhibitor of inducible nitric oxide synthase, restrained the elevation in NO level induced by DHT. Analyses of DHT-stimulated cells at the mRNA and protein levels confirmed the expression of inducible nitric oxide synthase. These findings suggest NO as a signaling molecule in human dermal papilla cells and implicate basal and androgen-mediated NO production to be involved in the regulation of hair follicle activity.

3. DHT also increases NO levels in the penis.

Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat.

4. And we all know that NO promotes aging, inflammation, Ray against it too.

It looks all confusing. What do you guys think ?

 

[ecstatichamster]

Nitric oxide studies done in 1995 should be very suspect due to drug company bias. Referencing the DHT study. I doubt most erections are really nitric oxide dependent.

 

[MrThyroid]

1. There are some claims that Cimetidine (H2 Antagonist) grows hair. It's attributed to anti-androgenic activity but see what haidut shared.

(Just like Famotidine and Ranitidine) Cimetidine shows anti-oxidant activity. It also scavenges nitric oxide. Maybe that anti-oxidant, anti-NO activity cause re-growth ?

2. And here a different study. Says that DHT (but not plain testosterone) promotes NO.

Nitric oxide in the human hair follicle

...This biomolecule is apparently formed by the endothelial isoform of nitric oxide synthase, which was detected at the mRNA and protein levels. Remarkably, basal NO level was enhanced threefold by stimulating dermal papilla cells with 5alpha-dihydrotestosterone (DHT) but not with testosterone. Addition of N-[3-(aminomethyl)benzyl]acetamidine (1400W), a highly selective inhibitor of inducible nitric oxide synthase, restrained the elevation in NO level induced by DHT. Analyses of DHT-stimulated cells at the mRNA and protein levels confirmed the expression of inducible nitric oxide synthase. These findings suggest NO as a signaling molecule in human dermal papilla cells and implicate basal and androgen-mediated NO production to be involved in the regulation of hair follicle activity.

3. DHT also increases NO levels in the penis.

Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat.

4. And we all know that NO promotes aging, inflammation, Ray against it too.

It looks all confusing. What do you guys think ?

i can totally agree with this DHT increase NO in hair follicle. Im used to took ginseng for about 3 months and when i trained heavy weight lifting i felt some weird sensation in my receding hairline.
This only happens if you really have high DHT. So dont worry about it btw eNO is sth. good there some studies suggesting that dropp of it will cause metabolic stress.

 

[MrThyroid]

i can totally agree with this DHT increase NO in hair follicle. Im used to took ginseng for about 3 months and when i trained heavy weight lifting i started to feel some weird sensation in my receding hairline.
This only happens if you really have high DHT. So dont worry about it btw eNO is sth. good there some studies suggesting that dropp of it will cause metabolic stress.

 

[managing]

Nitric oxide studies done in 1995 should be very suspect due to drug company bias. Referencing the DHT study. I doubt most erections are really nitric oxide dependent.

Based on?

 

[ecstatichamster]

One example

Understanding and targeting the Rho kinase pathway in erectile dysfunction
Erectile dysfunction (ED) is a common disorder that affects a quarter of US men, and has many causes, including endothelial impairment, low testosterone levels, prior surgical manipulation, and/or psychogenic components. Penile erection is a complex process requiring neurally mediated relaxation of arteriolar smooth muscle and engorgement of cavernosal tissues, mediated by nitric oxide (NO). Current medical therapies for ED largely seek to maximize endogenous NO signalling. Certain aetiologies, including diabetes, are difficult to treat with current modalities, emphasizing the need for new molecular targets. Research has demonstrated the importance of RhoA–Rho-associated protein kinase (ROCK) signalling in maintaining a flaccid penile state, and inhibition of RhoA–ROCK signalling potentiates smooth-muscle relaxation in an NO-independent manner. The mechanisms and effects of RhoA–ROCK signalling and inhibition suggest that the RhoA–ROCK pathway could prove to be a new therapeutic target for the treatment of ED.

 

[cats]

Methylene blue is probably a better alternative to histamine antagonists, no?

 

[managing]

One example

Understanding and targeting the Rho kinase pathway in erectile dysfunction
Erectile dysfunction (ED) is a common disorder that affects a quarter of US men, and has many causes, including endothelial impairment, low testosterone levels, prior surgical manipulation, and/or psychogenic components. Penile erection is a complex process requiring neurally mediated relaxation of arteriolar smooth muscle and engorgement of cavernosal tissues, mediated by nitric oxide (NO). Current medical therapies for ED largely seek to maximize endogenous NO signalling. Certain aetiologies, including diabetes, are difficult to treat with current modalities, emphasizing the need for new molecular targets. Research has demonstrated the importance of RhoA–Rho-associated protein kinase (ROCK) signalling in maintaining a flaccid penile state, and inhibition of RhoA–ROCK signalling potentiates smooth-muscle relaxation in an NO-independent manner. The mechanisms and effects of RhoA–ROCK signalling and inhibition suggest that the RhoA–ROCK pathway could prove to be a new therapeutic target for the treatment of ED.

The ROCK pathway to erection . . . nice!

 

[ecstatichamster]

The ROCK pathway to erection . . . nice!

Yes that is funny.

The reality is that nitric oxide is promoted by the drug companies because of PDE5 inhibitors such as Viagra. But the mechanism for erections really has little or nothing to do with nitric oxide in most cases. I believe this because whenever I have had very low nitric oxide as determined by a breath test for example, I still have had really good erections. Even when I was taking methylene blue and fairly high amounts. I don't think that nitric oxide mechanism for and erections is the primary mechanism at all. I think it's just a lie really.

 

[ddjd]

and Nitric oxide is what opposes CO2. go to high altitude (bolivia etc) - no bald people.

 

[Aleeri]

Yes that is funny.

The reality is that nitric oxide is promoted by the drug companies because of PDE5 inhibitors such as Viagra. But the mechanism for erections really has little or nothing to do with nitric oxide in most cases. I believe this because whenever I have had very low nitric oxide as determined by a breath test for example, I still have had really good erections. Even when I was taking methylene blue and fairly high amounts. I don't think that nitric oxide mechanism for and erections is the primary mechanism at all. I think it's just a lie really.

I have been thinking about this myself, somehow I think it would make more sense that it's more about the trigger that activates blood to flow there and form erections, not the amount of nitric oxide. Increasing nitric oxide via PDE5 inhibition would be more like forcing blood to fill the area (overriding trigger) and create erections which is obvious when you consider the reduced sensitivity/feeling (sex does not feel as good on viagra, you're more like a machine) as well as the side effects of pain and pressure such as headaches or in the lower back which I always get from cialis since the effect is prolonged. This is just me rambling my thoughts on this though.

Acetylcholine has always interested me concerning erections as well but not much research is done on it.

 

[Aleeri]

i can totally agree with this DHT increase NO in hair follicle. Im used to took ginseng for about 3 months and when i trained heavy weight lifting i felt some weird sensation in my receding hairline.
This only happens if you really have high DHT. So dont worry about it btw eNO is sth. good there some studies suggesting that dropp of it will cause metabolic stress.

I don't know how ginseng comes into this, it has some research on preventing hair loss, I use it in my topical and many famous companies make products with it as well. I never saw it as a NO booster in any different regard than cacao. Cacao is clearly more effective boosting NO but comes with no hair loss problems or we would have seen it by now.

What I keep seeing always on this forum is herbs often being viewed as having one directional effects like drugs, this is not the case. Adaptogens are called adaptogens because they have different effects according to the needs of the organism. The medical establishment has yet to explain how this happens and no research is being done on it because you cannot earn money on it. If that was done maybe we would have a blood pressure balancing drug rather than only lowering or raising ones.

And also, Ray has written good things about Ginseng just FYI.

 

[japanesedude]

Applying DHT precursor like Androsterone on Penis maybe a good way to improve erection quality.

 

[benaoao]

I’d much rather try to find ways to increase NO naturally when needed, through GH/IGF-1. So you get the double bonus of Better erections and better hair. And skin and nails and...

Indeed, “forcing” blood down there, or taking arginine/citrulline supplements, that is short sighted.

Which goes back to proper sleep, circadian rhythm, the whole loop

 

[ddjd]

better hair

I thought the whole point less NO equals better hair?

 

[ddjd]

1. There are some claims that Cimetidine (H2 Antagonist) grows hair. It's attributed to anti-androgenic activity but see what haidut shared.

(Just like Famotidine and Ranitidine) Cimetidine shows anti-oxidant activity. It also scavenges nitric oxide. Maybe that anti-oxidant, anti-NO activity cause re-growth ?

2. And here a different study. Says that DHT (but not plain testosterone) promotes NO.

Nitric oxide in the human hair follicle

...This biomolecule is apparently formed by the endothelial isoform of nitric oxide synthase, which was detected at the mRNA and protein levels. Remarkably, basal NO level was enhanced threefold by stimulating dermal papilla cells with 5alpha-dihydrotestosterone (DHT) but not with testosterone. Addition of N-[3-(aminomethyl)benzyl]acetamidine (1400W), a highly selective inhibitor of inducible nitric oxide synthase, restrained the elevation in NO level induced by DHT. Analyses of DHT-stimulated cells at the mRNA and protein levels confirmed the expression of inducible nitric oxide synthase. These findings suggest NO as a signaling molecule in human dermal papilla cells and implicate basal and androgen-mediated NO production to be involved in the regulation of hair follicle activity.

3. DHT also increases NO levels in the penis.

Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat.

4. And we all know that NO promotes aging, inflammation, Ray against it too.

It looks all confusing. What do you guys think ?

thanks for posting this. I also think Nitric Oxide and estrogen are the key reasons behind MPB. have you had any success with this approach since posting?

 

[LCohen]

thanks for posting this. I also think Nitric Oxide and estrogen are the key reasons behind MPB. have you had any success with this approach since posting?

It may be sound silly but Famotidine for some reason works for me. It's a nitric oxide scavenger.

You might wanna look pentoxifylline it's a powerful inhibitor of NO. It also has great anti-inflammatory, vasodilatory effects.

Some Pentoxifylline Studies

 

[ddjd]

It may be sound silly but Famotidine for some reason works for me. It's a nitric oxide scavenger.

You might wanna look pentoxifylline it's a powerful inhibitor of NO. It also has great anti-inflammatory, vasodilatory effects.

Some Pentoxifylline Studies

Interesting. I just got hold of some famotidine. But I also just read something about how it messes with electrical signalling of the heart or something?

What does ray say about pentoxifylline?

 

[benaoao]

I thought the whole point less NO equals better hair?

No, less excess NO means less inflammation equals better hair

But NO as a vasodilation molecule isn’t a problem in itself. The issue is inflammation, aka excess NO. It’s foolish to isolate each part of the inflammatory response and try to antagonize them. Waste of money

 

[Motif]

Anybody had success lowering NO?

Does methylene blue work for that?
What else would be worth a try?