- Mar 3, 2016
tca300: I understand this is off topic from what you typically teach, but I was wondering if you have run across any information or learned on your own, things that help people grieve over lost loved ones, and or fear of losing others to death? Thank you!
Ray Peat: It activates the “helplessness” reactions in the body, stress weakening your own life, and I think it can help to get out of that if you think of your life as a continuation of theirs—the same life, though with fewer bodies.
The funny thing is most middle eastern countries use this as a sprinkle over baked goods like sesame on burger buns in the west.
"[...] pharmacological activation of NRF2 is a promising therapeutic approach for several chronic diseases that are underlined by oxidative stress and inflammation, such as neurodegenerative, cardiovascular, and metabolic diseases. A particular case is cancer, where NRF2 confers a survival advantage to constituted tumors, and therefore, NRF2 inhibition is desired."
Good research ! Are you still talking this ?I know it isn’t very “Peaty” here because it contains PUFAs. Yet, the phytonutrients in this seed more than make up for it by strongly protecting against oxidative stress, lipid peroxidation, and assisting energy production. The main ingredient seems to be thymoquinone, a quinone obviously, but the whole seed usually works better than this single compound.
In this post though, I’m just going to post studies as it relates to thyroid hormone / function, because there are plenty. (Keep in mind, most of the human studies just used the ground seeds at 1g x 2 a day, but the most effective case series (image below) used 5g x 2 a day.
Effect of Safoof-e-kalonji (Nigella sativa) in the Managament of Subclinical Hypothyroidism
(Pre / Post values taken about a month apart) 10g total per day, seeds
View attachment 17540
The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: A randomized controlled trial
2g total per day, seed
View attachment 17541
Nigella Sativa treatment and serum concentrations of thyroid hormones, transforming growth factor β (TGF-β) and interleukin 23 (IL-23) in patients with Hashimoto’s Thyroiditis
2g total per day, seed
View attachment 17542
Effects of Nigella sativa L. Seed Extract on Fatigue, Blood Biochemical Parameters and Thyroid Function in Male Mice
Rodent study. Hydroalcoholic extract, so much higher human-equivalent doses than used in the human studies (doses listed below the table, highest dose would equal 2.8g of this “extract” for a large 91kg human.
View attachment 17543
Here’s a couple more:
- Can nigella sativa oil (nso) reverse hypothyroid status induced by PTU in rat? biochemical and histological studies | Request PDF
Can nigella sativa oil (nso) reverse hypothyroid status induced by PTU in rat? biochemical and histological studies
- Effects of Nigella sativa L. on serum concentrations of thyroid hormones, thyroid stimulating hormone and glucose in alloxan-induced diabetic rabbits | Request PDF
Effects of Nigella sativa L. on serum concentrations of thyroid hormones, thyroid stimulating hormone and glucose in alloxan-induced diabetic rabbits
- Study the effect of Nigella Sativa on thyroid function and reproductive hormone of female rat | Journal of Contemporary Medical Sciences
“Twelve females rats were used and divided randomly into two groups (6 animals for each) first group served as treatment and gave Nigella sativa oil (1ml /kg BW/day ) orally according to body weight for a period of 30 consecutive days. While other group drenched with normal saline at same dose that above mentioned and served as control.Results The result revealed significant increase in levels of LH, Estrogen T3 and T4 and significant decrease in level of TSH. Histological sections of thyroid gland revealed presence vaculation in colloid of thyroid follicle.Conclusion In conclusion, the Nigella sativa oil caused the elevation of thyroid hormones as well as LH and estrogen but still within normal value.”
Discussion: “Thyroid gland of female rats treated with Ns showed no histological changes when compare with the control except that some of the follicles were enlarged and containing vacuolated colloid as appear from Figure 2. This might be attributed to increased endocytotic activity of many follicular cells reflecting a compensatory mechanism to the augmented release of the stored hormones in the follicular lumen.”
- THE PROTECTIVE ROLE OF NIGELLA SATIVA OIL (NSO) AGAINST THYROID ULTRASTRUCTURAL CHANGES INDUCED BY EXPOSURE TO DI (2-ETHYLHEXYL) PHTHALATE (DEHP) | Request PDF
THE PROTECTIVE ROLE OF NIGELLA SATIVA OIL (NSO) AGAINST THYROID ULTRASTRUCTURAL CHANGES INDUCED BY EXPOSURE TO DI (2-ETHYLHEXYL) PHTHALATE (DEHP)
- [PDF] Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. | Semantic Scholar (Human study)
Lastly, this one isn’t thyroid-related, but this before and after treatment chart is just kinda insane.
(750mg x 2 a day, seed)
View attachment 17544
No one says you have to rely on it . It even if you did I dont see problem with it .Well I can’t imagine being on Thyroid for a while or even for a lifetime, I can’t really imagine being on an herb that long. There are just too many issues with that. It’s fine for occasional use or for short intervals but I can’t imagine relying on an herb for the duration. I can however easily imagine using intelligent T4 or T3 supplementation.