Nicotine, pro- or anti-inflammatory ?

[bagotage]

@HighT Thanks! Yeah, that Krumovgrad looks much nicer than the Burley, I'm excited to try it.

 

[Jessie]

The cholinergic effects may be something a large portion of the population wouldn't nesseciarly benefit from. That may be unironically less of a concern for us, though. Considering the bioenergetic spin on health pushes us more in an anticholinergic direction. In fact, getting too much anticholinergic activity would be bad as well. Something like nicotine (tobacco), B12, or choline may be useful if you're using a lot of anticholinergics.

 

[Mauritio]

Great stufy, done on rats, showing nicotine's pro-metabolic effects.

Nictotine increased UCP1and body temperature ,while maintaining muscle mass, especially on a high fat diet.
It also lowered liver fat (by about 50%) and inflammation.

Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats - PubMed

Nicotine, the main addictive component of tobacco, promotes body weight reduction in humans and rodents. Recent evidence has suggested that nicotine acts in the central nervous system to modulate energy balance. Specifically, nicotine modulates hypothalamic AMP-activated protein kinase to...

pubmed.ncbi.nlm.nih.gov

 

[youngsinatra]

Great stufy, done on rats, showing nicotine's pro-metabolic effects.

Nictotine increased UCP1and body temperature ,while maintaining muscle mass, especially on a high fat diet.
It also lowered liver fat (by about 50%) and inflammation.

Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats - PubMed

Nicotine, the main addictive component of tobacco, promotes body weight reduction in humans and rodents. Recent evidence has suggested that nicotine acts in the central nervous system to modulate energy balance. Specifically, nicotine modulates hypothalamic AMP-activated protein kinase to...

pubmed.ncbi.nlm.nih.gov

Wow, great find.

 

[Mauritio]

Anybody tried combining caffeine and nictotine?

They might synergize and caffeine lowers COX2 ,so should make nicotine safer.

Caffeine Decreases Nitric Oxide (NO) , Cox-2 Inhibitor

Didn't see this posted and is a fairly new study. Also, does anyone any ideas how this relates to endotoxin? I am quite new at looking at studies. Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. - PubMed - NCBI " Caffeine decreased the LPS-induced...

raypeatforum.com

 

[Mauritio]

Wow, great find.

Here's another one.

Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice

Although epidemiological data and results from rodent studies support an inverse relationship between nicotine consumption and body weight, the molecu…

www.sciencedirect.com

 

[Mauritio]

Nicotine against fatty liver:

- [Effects and mechanisms of the inflammatory reaction related to NASH and induced by activation of the cholinergic anti-inflammatory pathway] - PubMed

- [Effect of nicotinic acetylcholine receptor α7 subunit gene on liver inflammatory reaction in mice with nonalcoholic steatohepatitis and related mechanisms] - PubMed

- [Nicotine alleviates the liver inflammation of non-alcoholic steatohepatitis induced by high-fat and high-fructose in mice] - PubMed

 

[Mauritio]

After reading this review for the last week or so ,I think I got a better understanding of what nictoine does.
It talks about the exact same question as this thread and I think everyone, who thinks about using nicotine, should read it.

I agree with the author's statement from the abstract:

"According to the data analysis from recent studies in the past 20 years, nicotine exerts much more anti-inflammatory effects than pro-inflammatory ones, especially in ulcerative colitis, arthritis, sepsis, and endotoxemia. On the other hand, in oral inflammation, nicotine promotes and aggravates some diseases such as periodontitis and gingivitis, especially when there are harmful microorganisms in the oral cavity."

- Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects

 

[Jessie]

If one was wanting to experiment with nicotine, how would you think is the best method? Patches, gum, lozenges, or some other method?

 

[Sherbert]

If one was wanting to experiment with nicotine, how would you think is the best method? Patches, gum, lozenges, or some other method?

Patches being topical (not ingested) would probably b the least intrusive/abrasive. Problem is the light est patch would still b too heavy a dose given that haidut said something like a ~1/4 of a cigarette would b the max daily amount of nicotine before the risk s out weigh the benefits. Guess you could cut the patch up but would have to use bandaids to keep on the smaller section s

 

[Jessie]

Patches being topical (not ingested) would probably b the least intrusive/abrasive. Problem is the light est patch would still b too heavy a dose given that haidut said something like a ~1/4 of a cigarette would b the max daily amount of nicotine before the risk s out weigh the benefits. Guess you could cut the patch up but would have to use bandaids to keep on the smaller section s

Thanks. Yeah I was noticing on the patches some of them have really high amounts in them. Like 15-20mgs. About 1/4th of a cigarette is just a few milligrams at the most.

Of course, I'm assuming the patches are extended release. But even so 10mgs would be enough to last throughout the day.

 

[AlaskaJono]

After reading this review for the last week or so ,I think I got a better understanding of what nictoine does.
It talks about the exact same question as this thread and I think everyone, who thinks about using nicotine, should read it.

I agree with the author's statement from the abstract:

"According to the data analysis from recent studies in the past 20 years, nicotine exerts much more anti-inflammatory effects than pro-inflammatory ones, especially in ulcerative colitis, arthritis, sepsis, and endotoxemia. On the other hand, in oral inflammation, nicotine promotes and aggravates some diseases such as periodontitis and gingivitis, especially when there are harmful microorganisms in the oral cavity."

- Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects

Somewhere or several wheres in the past few years I read that smokers did not get 'covid'. I don't believe in covid, but.... interesting. It would be fascinating to find out if smokers were less susceptible to dying from the jabs, the old ACE2 receptor situation.... hmmmm.

 

[Sherbert]

Thanks. Yeah I was noticing on the patches some of them have really high amounts in them. Like 15-20mgs. About 1/4th of a cigarette is just a few milligrams at the most.

Of course, I'm assuming the patches are extended release. But even so 10mgs would be enough to last throughout the day.

True.. the alternative would be dividing up up a wad of gum or only part ly using a lozenge
lol obvious I've thought about this at length

 

[Mauritio]

Somewhere or several wheres in the past few years I read that smokers did not get 'covid'. I don't believe in covid, but.... interesting. It would be fascinating to find out if smokers were less susceptible to dying from the jabs, the old ACE2 receptor situation.... hmmmm.

There is evidence for that. Nictoine is anti-viral as well.

I also read that during some earlier plague they noticed that people in tobacco shops wouldnt get it. So many smoked for plague prevention:

"Those employed in the collection of bodies frequently smoked tobacco to avoid catching the plague.”
“For personal disinfections, nothing enjoyed such favor as tobacco; the belief in it was widespread, and even children were made to light up a reaf in pipes. Thomas Hearnes remembers one Tom Rogers telling him that when he was a scholar at Eton in the year that the great plague raged, all the boys smoked in school by order and that he was never whipped so much in his life as he was one morning for not smoking. It was long afterward a tradition that none who kept a tobacconist shop in London had the plague.”
- Nicotine & Testosterone: Is Smoking Tobacco Bad for Men?

 

[Mauritio]

If one was wanting to experiment with nicotine, how would you think is the best method? Patches, gum, lozenges, or some other method?

I use topical application of liquid nicotine. Just 1mg.

 

[Sherbert]

There is evidence for that. Nictoine is anti-viral as well.

I also read that during some earlier plague they noticed that people in tobacco shops wouldnt get it. So many smoked for plague prevention:

"Those employed in the collection of bodies frequently smoked tobacco to avoid catching the plague.”
“For personal disinfections, nothing enjoyed such favor as tobacco; the belief in it was widespread, and even children were made to light up a reaf in pipes. Thomas Hearnes remembers one Tom Rogers telling him that when he was a scholar at Eton in the year that the great plague raged, all the boys smoked in school by order and that he was never whipped so much in his life as he was one morning for not smoking. It was long afterward a tradition that none who kept a tobacconist shop in London had the plague.”
- Nicotine & Testosterone: Is Smoking Tobacco Bad for Men?

This is fascinating.

 

[Mauritio]

This podcast also has some interesting bits about nicotine.


View: https://youtu.be/uXs-zPc63kM

 

[bagotage]

If one was wanting to experiment with nicotine, how would you think is the best method? Patches, gum, lozenges, or some other method?

I never see anyone mention tea, but I put one or two small tobacco leaves in my morning tea blend every day.

I suspect there are synergistic effects with the tobacco plant, that are not present when using isolated nicotine extracts.

In Tao Lin's Leave Society he mentions drinking "tobacco water," so I suspect he's doing some kind of cold-water extraction there, which is what gave me the idea to try putting it in herbal tea.

 

[DonLore]

Why does nicotine increase periodontal disease and gum inflammation?

 

[Jessie]

I never see anyone mention tea, but I put one or two small tobacco leaves in my morning tea blend every day.

I suspect there are synergistic effects with the tobacco plant, that are not present when using isolated nicotine extracts.

In Tao Lin's Leave Society he mentions drinking "tobacco water," so I suspect he's doing some kind of cold-water extraction there, which is what gave me the idea to try putting it in herbal tea.

That's interesting, never considered that before. Probably tastes like #$%@. Wonder if you could add a little to ground coffee? I use the "pour over" method, maybe you could just add some tobacco on top of the ground?