Nicergoline is a "smart drug", some people use it for its nootropic value. In medicine it is mostly given to old people to improve cognitive function. Wondering if anyone has any experience with it? It is an ergot derived drug, but the risk for fibrosis and ergotism seems very small (compared with other ergot drugs).
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Nicergoline - Experiences?
- Thread starter dookie
- Start date
KyleKingsly
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- Feb 15, 2018
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Bumping this since I was considering my own thread on this exact topic. Very curious about what people have to say; there are some very promising reports available over here: Loading site please wait...
General Orange
Member
Neuroprotection and aging of the cholinergic system: a role for the ergoline derivative nicergoline (Sermion). - PubMed - NCBI
"Colchicine induces a rapid and substantial down-regulation of choline acetyltransferase messenger RNA level in the basal forebrain in untreated adult, middle-aged and old rats. Colchicine failed to cause these effects in old rats treated for 120 days with nicergoline 10 mg/kg/day, orally. Moreover, a concomitant increase of both nerve growth factor and brain-derived neurotrophic factor content was measured in the basal forebrain of old, nicergoline-treated rats. Additionally, the level of messenger RNA for the brain isoform of nitric oxide synthase in neurons of the basal forebrain was also increased in these animals."
increasing Nitric oxide can be very bad for the brain. Not Peatish.
"Colchicine induces a rapid and substantial down-regulation of choline acetyltransferase messenger RNA level in the basal forebrain in untreated adult, middle-aged and old rats. Colchicine failed to cause these effects in old rats treated for 120 days with nicergoline 10 mg/kg/day, orally. Moreover, a concomitant increase of both nerve growth factor and brain-derived neurotrophic factor content was measured in the basal forebrain of old, nicergoline-treated rats. Additionally, the level of messenger RNA for the brain isoform of nitric oxide synthase in neurons of the basal forebrain was also increased in these animals."
increasing Nitric oxide can be very bad for the brain. Not Peatish.
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