Niacinamide / Nicotinamide Has A Glycogen-sparing Effect

[haidut]

This may be one of its anti-stress mechanisms, in addition to its benzo similarities.

http://www.ncbi.nlm.nih.gov/pubmed/2963642

"...The inhibitory action of nicotinic acid, nicotinamide, N-nicotinoyl-gamma-aminobutyric acid, NAD, NADH, NADP, and NADPH on the rabbit skeletal muscle glycogen phosphorylase b has been studied. The inhibition is reversible and positively cooperative..."

The enzyme "glycogen phosphorylase b" breaks down glycogen, and based on the above study niacin / niacinamide and their products NAD(P)(H) inhibit it in muscles, thus keeping glycogen levels high.

 

[Such_Saturation]

Do you think all the properties of this vitamin combined might make it unwise to take it without enough sugar?

 

[haidut]

Do you think all the properties of this vitamin combined might make it unwise to take it without enough sugar?

I have to say yes, and I suspect the same is true for thiamine (B1), biotin, and riboflavin (B2). Not sure about pyridoxine (B6).