Giraffe
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The effect of niacinamide on osteoarthritis: A pilot study
In the 1940's and 50's William Kaufman treated several hundred patients with both osteo and rheumatoid arthritis with large doses of niacinamide. The researchers here are following Kaufman's approach. They conducted a three month study, using a randomized double-blind, placebo-controlled design.
"Dosage was one tablet six times daily for 12 weeks (a total of 3000 mg/day)."
"This study indicates that niacinamide may have a role in the treatment of osteoarthritis. Niacinamide improved the global impact of osteoarthritis, improved joint flexibility, reduced ESR, and allowed for reduction in anti-inflammatory medications when compared to placebo."
"Side effects were mild and due almost exclusively to gastrointestinal (GI) disturbances such as eructations, nausea, or loose stools and were managed by having subjects take the medicine with food or extra fluids. Twelve subjects (40%) in the niacinamide group reported side effects compared to eight (27%) of those on placebo (X2 = 4.48; p = 0.034) (Table 3, Fig. 1). Eleven subjects on niacinamide and two on placebo experienced nausea or heartburn. Kaufman reported that between one and three months was the minimum amount of time needed to see improvement in joint function while on niacinamide which then reached its maximum effect in one to three years. If niacinamide works by improving cartilage repair mechanisms, as discussed below, this study was not long enough to detect evidence for this."
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For more information on Kaufman's work please check aguilaroja's post here.
In the 1940's and 50's William Kaufman treated several hundred patients with both osteo and rheumatoid arthritis with large doses of niacinamide. The researchers here are following Kaufman's approach. They conducted a three month study, using a randomized double-blind, placebo-controlled design.
"Dosage was one tablet six times daily for 12 weeks (a total of 3000 mg/day)."
"This study indicates that niacinamide may have a role in the treatment of osteoarthritis. Niacinamide improved the global impact of osteoarthritis, improved joint flexibility, reduced ESR, and allowed for reduction in anti-inflammatory medications when compared to placebo."
"Side effects were mild and due almost exclusively to gastrointestinal (GI) disturbances such as eructations, nausea, or loose stools and were managed by having subjects take the medicine with food or extra fluids. Twelve subjects (40%) in the niacinamide group reported side effects compared to eight (27%) of those on placebo (X2 = 4.48; p = 0.034) (Table 3, Fig. 1). Eleven subjects on niacinamide and two on placebo experienced nausea or heartburn. Kaufman reported that between one and three months was the minimum amount of time needed to see improvement in joint function while on niacinamide which then reached its maximum effect in one to three years. If niacinamide works by improving cartilage repair mechanisms, as discussed below, this study was not long enough to detect evidence for this."
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For more information on Kaufman's work please check aguilaroja's post here.