haidut

Member
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
Several people on the forum have experienced issues with kidney function, and it is a common co-morbidity in people with diabetes or autoimmune conditions like Lupus. Some steroids like androsterone, and progesterone have strong evidence in their favor for restoring kidney function, but they are in accessible in many countries around the world. This study shows that a HED dose of about 30mg/kg niacinamide for 4 days fully restored kidney function. The study only looked at acute kidney injury (AKI) but the mechanisms apply to chronic kidney disease as well. The cisplatin treatment mentioned in below is an established animal model for causing chronic kidney disease. For chronic kidney disease the treatment with niacinamide should probably longer term (1-2 months) to see an effect. Vitamin D is also very important for restoring kidney function.

https://www.sciencedaily.com/releases/2016/03/160316151353.htm
http://www.nature.com/nature/journal/v531/n7595/full/nature17184.html
"...Renal protection was similarly abolished in either setting, confirming their roles as PGC1α effectors (Fig. 4a, b, Extended Data Fig. 7d, e). Since NAM prevented ischaemic AKI in Pgc1α−/− mice, we then asked whether NAM has a broader therapeutic role. NAM administered after established AKI significantly improved renal function (P=0.0011, Fig. 4c). We also observed that renal NAM declined following cisplatin, a chemotherapy that injures the kidney through a mechanism considered distinct from ischaemia (Extended Data Fig. 7f, g). NAM supplementation prevented cisplatin-induced AKI (Fig. 4d, e)."

Interestingly, there is already a human trial with 30mg/kg daily niaciamide for treating polycystic kidney disease, which is a type of chronic kidney disease (CKD).
Pilot Study of Niacinamide in Polycystic Kidney Disease (NIAC-PKD2) - Full Text View - ClinicalTrials.gov
 
Last edited:

Koveras

Member
Joined
Dec 17, 2015
Messages
719
Several people on the forum have experienced issues with kidney function, and it is a common co-morbidity in people with diabetes or autoimmune conditions like Lupus. Some steroids like androsterone, and progesterone have strong evidence in their favor for restoring kidney function, but they are in accessible in many countries around the world. This study shows that a HED dose of about 30mg/kg niacinamide for 4 days fully restored kidney function. The study only looked at acute kidney injury (AKI) but the mechanisms apply to chronic kidney disease as well. The cisplatin treatment mentioned in below is an established animal model for causing chronic kidney disease. For chronic kidney disease the treatment with niacinamide should probably longer term (1-2 months) to see an effect. Vitamin D is also very important for restoring kidney function.

https://www.sciencedaily.com/releases/2016/03/160316151353.htm
http://www.nature.com/nature/journal/v531/n7595/full/nature17184.html
"...Renal protection was similarly abolished in either setting, confirming their roles as PGC1α effectors (Fig. 4a, b, Extended Data Fig. 7d, e). Since NAM prevented ischaemic AKI in Pgc1α−/− mice, we then asked whether NAM has a broader therapeutic role. NAM administered after established AKI significantly improved renal function (P=0.0011, Fig. 4c). We also observed that renal NAM declined following cisplatin, a chemotherapy that injures the kidney through a mechanism considered distinct from ischaemia (Extended Data Fig. 7f, g). NAM supplementation prevented cisplatin-induced AKI (Fig. 4d, e)."

Interestingly, there is already a human trial with 30mg/kg daily niaciamide for treating polycystic kidney disease, which is a type of chronic kidney disease (CKD).
Pilot Study of Niacinamide in Polycystic Kidney Disease (NIAC-PKD2) - Full Text View - ClinicalTrials.gov

Probably also related to the phosphate lowering effect
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
Probably also related to the phosphate lowering effect

Great point! And lowering PTH as well. I think I posted a few studies on the forum on 1g niacinamide daily lowering both phosphate and PTH in people with kidney disease.
 

nullredvector

Member
Joined
Oct 17, 2013
Messages
195
Age
32
Location
USA
Great point! And lowering PTH as well. I think I posted a few studies on the forum on 1g niacinamide daily lowering both phosphate and PTH in people with kidney disease.
Yeah when I take over 1g I get massive cravings for high phosphate foods like meat and bread
 
Joined
Nov 26, 2013
Messages
7,367
Would magnesium stearate diminish these good effects?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe

moriwatzi

Member
Joined
Jan 22, 2013
Messages
100
@haidut great find! Do you think it is necessary to take the 30mg/kg at once or will split in 3 doses probably work as well? Single dose would be around 2,7 grams for me, so coming close to the 3 g inhibiting liver respiration....

Speaking of dose, how much Androsterone would you imagine Doctors could use for treating kidney disease?

Thanks a lot!
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
@haidut great find! Do you think it is necessary to take the 30mg/kg at once or will split in 3 doses probably work as well? Single dose would be around 2,7 grams for me, so coming close to the 3 g inhibiting liver respiration....

Speaking of dose, how much Androsterone would you imagine Doctors could use for treating kidney disease?

Thanks a lot!

Taking the 3g at once may reach the respiration inhibiting concentration, so I would go with 1g x 3 daily instead. It should still have the same effect on kidneys as it is the NAD that matters and not the niacinamide levels.
 

moriwatzi

Member
Joined
Jan 22, 2013
Messages
100
Taking the 3g at once may reach the respiration inhibiting concentration, so I would go with 1g x 3 daily instead. It should still have the same effect on kidneys as it is the NAD that matters and not the niacinamide levels.

thanks, haidut! Did you see these two studies too? Effects of low-dose niacin on dyslipidemia and serum phosphorus in patients with chronic kidney disease

Conclusion
Low-dose niacin had a low frequency of adverse effects and also improved dyslipidemia, lowered serum phosphorus level, and increased GFR in patients with CKD. Further studies are needed to evaluate the long-term effects of low-dose niacin for renal progression of CKD.
Effect of low dose nicotinic acid on hyperphosphatemia in patients with end stage renal disease

Conclusion
We conclude that niacin (100 mg/day) decreased phosphorus serum level and increased HDL serum level in patients on dialysis.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
thanks, haidut! Did you see these two studies too? Effects of low-dose niacin on dyslipidemia and serum phosphorus in patients with chronic kidney disease

Conclusion
Low-dose niacin had a low frequency of adverse effects and also improved dyslipidemia, lowered serum phosphorus level, and increased GFR in patients with CKD. Further studies are needed to evaluate the long-term effects of low-dose niacin for renal progression of CKD.
Effect of low dose nicotinic acid on hyperphosphatemia in patients with end stage renal disease

Conclusion
We conclude that niacin (100 mg/day) decreased phosphorus serum level and increased HDL serum level in patients on dialysis.

Yes, I have seen them and there are some studies with niacinamide lowering phosphorus in CKD as well. The increase in HDL by plain niacin is not necessarily a good thing. It suggests niacin is viewed as a toxin by the organism, maybe due to it releasing histamine??
 

JackHanma

Member
Joined
Jul 27, 2016
Messages
313
Location
Canada
Yes, I have seen them and there are some studies with niacinamide lowering phosphorus in CKD as well. The increase in HDL by plain niacin is not necessarily a good thing. It suggests niacin is viewed as a toxin by the organism, maybe due to it releasing histamine??
Niacin releases histamine? Searching about that and found this:

"It's my understanding that niacin (any form) increases histamine release, and the release of other compounds from mast cells, but that doesn't mean they're released or dumped from the body.

Instead, since niacin is a methyl-acceptor, it blocks methylation (which helps degrade or break down histamine) and actually increases histamine levels in the body.

Excess nicotinamide increases plasma serotonin and histamine levels. - PubMed - NCBI

This can be a huge problem for those who develop histamine intolerance, as both methylation (and the DAO enzyme in the gut) need to function properly or histamine levels just increase and increase resulting in serious health consequences:

Histamine and histamine intolerance. - PubMed - NCBI"

I drink very strong coffee, quite a bit, which is high in niacin. I notice that I keep getting new moles all over my skin (which if not iron/pufa based is related to mast cell abnormalities) I wonder if there is a correlation? Or is the histamine simply released and then inevitably destroyed long-term and decreased?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
Niacin releases histamine? Searching about that and found this:

"It's my understanding that niacin (any form) increases histamine release, and the release of other compounds from mast cells, but that doesn't mean they're released or dumped from the body.

Instead, since niacin is a methyl-acceptor, it blocks methylation (which helps degrade or break down histamine) and actually increases histamine levels in the body.

Excess nicotinamide increases plasma serotonin and histamine levels. - PubMed - NCBI

This can be a huge problem for those who develop histamine intolerance, as both methylation (and the DAO enzyme in the gut) need to function properly or histamine levels just increase and increase resulting in serious health consequences:

Histamine and histamine intolerance. - PubMed - NCBI"

I drink very strong coffee, quite a bit, which is high in niacin. I notice that I keep getting new moles all over my skin (which if not iron/pufa based is related to mast cell abnormalities) I wonder if there is a correlation? Or is the histamine simply released and then inevitably destroyed long-term and decreased?

The flushing that regular niacin causes is due to histamine. That is why aspirin helps tone it down. Niacinamide does not seem to have this effect.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
Does niacin also help with kidneys or is the effect only due niacinamide

Both seem to lower phosphate and PTH in human trials with CKD.
 

sugarbabe

Member
Joined
Sep 13, 2012
Messages
3,331
Niacin releases histamine? Searching about that and found this:

"It's my understanding that niacin (any form) increases histamine release, and the release of other compounds from mast cells, but that doesn't mean they're released or dumped from the body.

Instead, since niacin is a methyl-acceptor, it blocks methylation (which helps degrade or break down histamine) and actually increases histamine levels in the body.

Excess nicotinamide increases plasma serotonin and histamine levels. - PubMed - NCBI

This can be a huge problem for those who develop histamine intolerance, as both methylation (and the DAO enzyme in the gut) need to function properly or histamine levels just increase and increase resulting in serious health consequences:

Histamine and histamine intolerance. - PubMed - NCBI"

I drink very strong coffee, quite a bit, which is high in niacin. I notice that I keep getting new moles all over my skin (which if not iron/pufa based is related to mast cell abnormalities) I wonder if there is a correlation? Or is the histamine simply released and then inevitably destroyed long-term and decreased?
I have not heard of anecdotal reports of histamine intolerance due to niacinamide, so it may not be black and white. I've been on 50-100mg for 6 months and I do not get diarrhea, headaches, rhinitis from it. In the beginning I did get headaches. I am also on ascorbic acid so maybe it has offset some of it.
 

The_xXx

Member
Joined
Mar 25, 2017
Messages
41
if i think logically it does seem when kidney are harmed or in bad state it does mean they dont have enough energy to maintain their recovery or sustain ? Because niacin and Niacinamide shift the metabolism to glucose right = more energy . Because i have developed a harmless kidneycyst in my right kidney. Doctor told me that it contains some fluid. And im really worried about this dont want that it get worse. My theory is why then all other organs get enough energy and dont get harmed. I think i harmed my kidney , because i lost alot of bad fat mainly maybe pufa which contains alot of toxin and my kidney want to save itself from it and maybe stores those bad toxins which get release when pufa breaksdown in this Kidneycyst. So when i take take niacin or niacinamide maybe stops or downregulates fatburning in favour of carb burning then i stop burn the pufas and toxins stop releasing and kidney can rest.

Haidcut can you confirm or give a statement of this theory, because its a reeally bad thing if your feel your area arround your kidney is like clogged or sth. . Maybe its caused due bacterias. Im really thinking of going to Doctor and telling him give me antibiotics. But the only thing im worried is that i maybe harm more my kidneys by taking an antibiotics because its maybe more burden to them .
 

JackHanma

Member
Joined
Jul 27, 2016
Messages
313
Location
Canada
The flushing that regular niacin causes is due to histamine. That is why aspirin helps tone it down. Niacinamide does not seem to have this effect.
Interesting. I wonder if foods high in niacin fall into this category or if they are handled differently by the body.
 
Similar threads
Thread starter Title Forum Replies Date
haidut Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study Scientific Studies 5
haidut Niacinamide may treat ALS by improving energetic state Scientific Studies 0
haidut Niacinamide may treat depression by improving energetic state Scientific Studies 8
haidut Niacinamide May Treat Fibrotic Eye Disease And Prevent Vision Loss Scientific Studies 5
haidut Niacinamide May Help Treat/reverse Heart Disease Scientific Studies 1
haidut Niacinamide Can Treat Alcoholic Liver Disease Scientific Studies 3
Koveras Tuberculosis Depletes NAD+ (and Niacinamide May Be Able To Treat It) Scientific Studies 1
haidut Niacinamide May Treat Brain Cancer (glioblastoma) Scientific Studies 8
haidut Niacinamide And Doxycycline May Treat Alzheimer Disease (AD) Scientific Studies 7
haidut Niacinamide May Treat ALS (and Stroke) Scientific Studies 6
haidut High-dose Vitamin C Or Niacinamide May Treat Advanced Colon Cancer Scientific Studies 12
haidut Vitamin B3 (niacinamide) Can Treat Pre-eclampsia Scientific Studies 6
haidut Niacinamide Can Help Treat Highly Drug-resistant Bacterial Infections Scientific Studies 21
haidut Rheumatoid Arthritis Is A Metabolic Disease; Vitamin K And Niacinamide May Treat It Scientific Studies 57
haidut Niacinamide May Treat Hepatitis B Scientific Studies 1
haidut Niacinamide May Be Able To Treat Both HIV And Tuberculosis Scientific Studies 2
C Whats the verdict on Niacin/Niacinamide? Supplements, Pharmaceutical Drugs 26
IROM Alpecin shampoo: Caffeine, Taurine and Niacinamide (are corporations on to Peating?) Hair & Nails 9
youngsinatra High Dose Niacinamide Self-Experiment. Experiments 29
haidut Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide Scientific Studies 2
S Aspirin, niacinamide and eye bags Supplements, Pharmaceutical Drugs 7
J Niacinamide Ask For Help or Advice 15
SOMO Niacinamide + Vit C = Niacin? Ask For Help or Advice 0
Razvan Niacinamide Help Ask For Help or Advice 1
pauljacob Can I Break Open A Niacinamide, Pregnenolone Capsule? Supplements, Pharmaceutical Drugs 4
charlie Vitamin B3 (Niacinamide) Shows Promise For Glaucoma Patients In Clinical Trial Scientific Studies 2
snacks Niacinamide And Dandruff Skin 2
haidut Niacinamide (vitamin B3) May Cure HIV (human Study) Scientific Studies 9
ddjd Niacinamide Great For Sleep. Niacin Terrible. Why? Ask For Help or Advice 10
Hgreen56 Niacinamide Inhibits Fatloss And Niacin Improve It? Supplements, Pharmaceutical Drugs 10
ampersand Ataxia, Iron, Methylene Blue, Niacinamide Supplements, Pharmaceutical Drugs 2
C Aspirin/Niacinamide/Pyrucet Supplements, Pharmaceutical Drugs 7
meatbag Has Anyone Ever Taken 5g+ Niacinamide In One Sitting? Experiments 18
Orangeyouglad Any Ideas On Tolerating Niacinamide? Supplements, Pharmaceutical Drugs 5
haidut Low-dose (but Not High) Niacinamide Reverses Reproductive Decline In Old Females Scientific Studies 6
W Niacinamide And Depression B3/Niacinamide 19
G Niacinamide Long Term Use Cortisol, Serotonin, Histamine 16
Ficini Niacinamide Topical Vs Oral Clarification B3/Niacinamide 2
haidut Dietary Niacinamide (B3) Deficiency May Be A Cause Of Schizophrenia Scientific Studies 7
SOMO Niacinamide Causing Skin Issues For Anyone Else? Supplements, Pharmaceutical Drugs 0
Batbat Niacinamide Inhibits Hair Growth B3/Niacinamide 7
haidut Niacinamide May Restore Female Fertility In Old Age Scientific Studies 17
Jewbermensch Niagen Worth It Over Niacinamide? Supplements, Pharmaceutical Drugs 22
haidut Niacinamide May Improve Symptoms Of ALS Scientific Studies 1
E Issues After Taking High Dose Niacinamide Supplements, Pharmaceutical Drugs 17
Inaut I Think I’ve Finally Figured Out How To Use Niacinamide B3/Niacinamide 82
T How Much Aspirin And Niacinamide? Female 44 Yrs Fatigue And Heavy Menstruation Supplements, Pharmaceutical Drugs 5
A Niacin NOT The Same As Niacinamide, Acts Differently Regarding Lipolysis? Vitamins 13
Amazigh Niacinamide + Methyl Donor To Avoid Histamine Increase? Supplements, Pharmaceutical Drugs 6
olive Nicotinamide (niacinamide) Induces Liver Regeneration & Improves Liver Function By Activating SIRT1 Scientific Studies 52

Similar threads

Top