Niacinamide - A Potent Anti-anxiety Drug

[haidut]

For those of you who are interested, and believe in the receptor theory (Ray Peat does not I think), here is some interesting info. Niacinamide in human doses of 1500mg - 3000mg daily is potent anti-anxiety drug similar in action to the benzodiazepine class of drugs like Diazepam, Valium, and Xanax.

http://www.ncbi.nlm.nih.gov/pubmed/6101294
http://www.ncbi.nlm.nih.gov/pubmed/6125374
http://www.ncbi.nlm.nih.gov/pubmed/7913840

I can personally attest to the fact that anything above 1500mg dosage at once makes me the mellowest, nicest...and sleepiest person

 

[honeybee]

Do or Did you ever get headaches from high dosage? Did you work your way up to taking high doses?

 

[charlie]

Has anyone else experimented with higher doses of niacinamide?

 

[Peata]

I did a couple times several years back. The first time it made me drowsy and I took a nap. The second time it made me nauseous and feel bad. I didn't take high doses anymore after that. Maybe if I'd experimented more, but I just didn't.

 

[charlie]

I just did 500mg so will see what happens.

 

[4peatssake]

I just did 500mg so will see what happens.

 

[HDD]

Thanks for the laugh this morning!

 

[Peata]

I've thought about getting some more and trying it again, since back when I took it before I didn't have the best diet and was under extreme stress, so I'm sure my body chemistry was askew.

 

[jyb]

I just did 500mg so will see what happens.

That's the content of just one pill from the brand I have, so I doubt you'll see much difference. I mean I usually open the pill to get 50mg for a physiological dose, but the common user takes the whole pill.

 

[Dewitt]

I took up to 5g for a while and didn't really notice any effect from it.

 

[Ben]

I'm taking about 3g of niacinamide a day, but I doubt I could handle more without nausea. I read that overmethylators, people with lots of monoamines, respond badly to SSRIs, but well to benzodiazepines. I tend to side with on this side of the scale and responded badly to Benadryl and well to Tianeptine.

Anyway, benzodiazepines slow respiratory rate. This is beneficial due to CO2 building up. However, I'm uncertain of whether GABAergic depressants can slow respiration in the long-term, or if tolerance builds up and that effect disappears.

 

[member 2106]

I'm taking about 3g of niacinamide a day, but I doubt I could handle more without nausea. I read that overmethylators, people with lots of monoamines, respond badly to SSRIs, but well to benzodiazepines. I tend to side with on this side of the scale and responded badly to Benadryl and well to Tianeptine.

Anyway, benzodiazepines slow respiratory rate. This is beneficial due to CO2 building up. However, I'm uncertain of whether GABAergic depressants can slow respiration in the long-term, or if tolerance builds up and that effect disappears.

Hey Ben, I know this is an old post, but can you expand more on the concept of "overmethylators"? I respond well to benzodiazepines but badly (with limited experience) to SSRIs. I'm planning to supplement with niacinamide to see if it has any anti-anxiety effects for me. I had a quick look at what an "overmethylator" was, and found it striking how many traits I had in common. Any further insight?

 

[johnwester130]

Niacinamide is an incredible supplement.

It's better than thyroid supplementation.

 

[lollipop]

Niacinamide is an incredible supplement.

It's better than thyroid supplementation.

Hi @johnwester130, curious: do you take it regularly? If so, how much and how often? What direct benefits do you see in yourself?

Thank you in advance.

 

[johnwester130]

Hi @johnwester130, curious: do you take it regularly? If so, how much and how often? What direct benefits do you see in yourself?

Thank you in advance.

just a general uplift in energy and calmness,

500mg everyday

 

[Lee Simeon]

just a general uplift in energy and calmness,

500mg everyday

Bruh, 500 mg?

 

[johnwester130]

Bruh, 500 mg?

what's wrong with that

 

[Lee Simeon]

what's wrong with that

I do think that 500 mg is a tad to much, but if you feel great doing it, by all means continue.

 

[sladerunner69]

I do think that 500 mg is a tad to much, but if you feel great doing it, by all means continue.

Did you read the first post? Those studies were using upwards of 3000mg's.

 

[tomisonbottom]

just a general uplift in energy and calmness,

500mg everyday

Do you still do this, and do you separate the dose out, or just take all at once?