New study on blood glucose and age, finds stark contrast between mice and humans.

[Ritchie]

This recent study is interesting as it highlights the importance of distinguishing rodent and human research. Not sure what explains it but they found a complete 180 degree difference in results when comparing blood glucose and mortality between humans to rodents.

Fasting blood glucose as a predictor of mortality: Lost in translation

Fasting blood glucose is widely used to measure metabolic health, and mice are used to model age-associated metabolic diseases in humans. Here, Palliyaguru and Shiroma et al. reveal that fasting blood glucose trajectories and mortality risk associations differ between species—a cautionary tale...

www.cell.com

Fasting blood glucose as a predictor of mortality: Lost in translation - PubMed

Aging leads to profound changes in glucose homeostasis, weight, and adiposity, which are considered good predictors of health and survival in humans. Direct evidence that these age-associated metabolic alterations are recapitulated in animal models is lacking, impeding progress to develop and...

pubmed.ncbi.nlm.nih.gov

"In contrast, fasting blood glucose decreased late in life in mice but increased over the lifespan of nonhuman primates and humans. Higher glucose was associated with lower mortality in mice but higher mortality in nonhuman primates and humans, providing a cautionary tale for translating age-associated metabolic changes from mice to humans."

"The association of glucose with survival is inverse for mice versus monkeys/humans"

Curious to hear peoples thoughts on this..

 

[Daniil]

Thank you, it's interesting