New Findings Link Estrogen And T Cell Immune Response To Autoimmune Inflammation

Mito

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New findings link estrogen and T cell immune response to autoimmune inflammation

“Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system. A team of scientists from Turku Center for Biotechnology and University of Georgia reported new findings related to the involvement of estrogen hormone receptor in autoimmune diseases.

The incidence of autoimmune diseases such as MS, RA, and SLE is higher in women than in men. The estrogen hormone secreted in women may contribute to the pathogenesis of these diseases.

A research team led by Docent Zhi Chen from Turku Center for Biotechnology of the University of Turku has collaborated with researchers from the University of Georgia, United States to address the long-standing issue of hormonal effect on autoimmune diseases.

Estrogen hormone shows its action on cells mostly through estrogen receptor alpha (ERα). Researchers from Turku generated mice with ERα protein specifically deleted in T cells.

- The eureka moment of our research is that in a mouse model of human inflammatory bowel disease, transfer of naive T helper cells from ERα deficient mice did not succumb to colitis, unlike transfer from their counterparts, Docent Zhi Chen tells.

- Furthermore, using cutting-edge technique RNA sequencing approach combined with in vitro and in vivo experiments, we discovered that ERα regulates multiple aspects of T cell function, including T cell activation, proliferation and survival, Chen adds.

Regulatory T cells are group of T cells that help in preventing autoimmune diseases. The researchers found that ERα influences the function and differentiation of regulatory T cells.”

Estrogen receptor α contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation. - PubMed - NCBI
 
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Mito

Mito

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HD - “...you talk a lot about estrogen as being a very negative pro inflammatory hormone, I mean that’s correct enough isn’t it?”

RP - “...in general it activates the immune system in a short term antibody producing way that is in certain situations useful but it’s why women have a very high incidence of autoimmune disorders because it impairs the energy resources at the same time that it’s making these short term emergency changes in the immune system.”

KMUD: 12-18-15 Nitric Oxide, Nitrates, Nitrites, and Fluoride
 

Vinero

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Does high estrogen lead to autoimmune diseases? Or does having an autoimmune disease increase estrogen production?
If you cure one you cure the other. Lowering inflammation is the key.
 

benaoao

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Well you don’t “get” an autoimmune disease out of nowhere plus I don’t really believe in autoimmune diseases being a thing. It would be better to perceive them as a cellular energy imbalance where the body has to “sacrifice” its own unproductive cells to keep rolling.

So whatever leads to inflammation and high estrogen is the cause. All my money is on lifestyle (see the blue zones pyramid for lifestyle “misbehaviors”) + special emphasis on dietary choices. Obv some genetics to a degree.
 

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