Neonatal Hypothyroidism Due To Mothers VEGAN Diet

GelatinGoblin

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Yes. In a low vitamin A condition it will cleave more carotenes.


Well, vitamin A (as retinoic acid) and vitamin D (as calcitriol) have nuclear receptors. These are proteins within the nucleus of the cell with zinc fingers that bind directly to DNA. Thyroid hormone also has a nuclear receptor, and they exist in pairs.

RAR = retinoic acid receptor
RXR = retinoid X receptor
VDR = vitamin D receptor
TR = thyroid receptor
LXR = liver X receptor

They exist as heterodimers to RXR.

RXR–RAR
RXR–VDR
RXR–TR
RXR–LXR

And are found clamped to DNA. I'll see if I can find a good illustration...
nsmb.2778-F1.jpg

Structure of the retinoid X receptor liver X receptor (RXR–LXR) heterodimer on DNA



Retinoid X receptor is the most common nuclear receptor and is found connected to RAR, VDR, TR, and LXR.

So vitamin D can influence RNA expression directly. Along with parathyroid hormone (PTH), it also helps to maintain blood calcium and phosphate levels. The article Vitamins as Hormones is exclusively about vitamins A and D. Here is the 'table of contents' from that article.

Table of Contents


I bet there is enough research already done on this. Just get Sci-Hub and you can read nearly every article in print.

Your biochemistry and whatever you are specialising in is awe some but your dietary principles are less sophisticated and questionable, perhaps sophisticated when you focus on the right parts of Biochemistry but less so if you consider the rest of the factors. The Amino Acid profile in non animal foods is simply non-sufficicent, perhaps in some foods like the Potato otherwise Kwashiwoker would've been epidemiological in the Soviet Union from 1940-1970. Nowadays such a diet would not be sustainable due to the slowed metabolism of today.
 
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