Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity

[iROH]

Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity
"Ever since researchers realized the value of the immune system in the fight against cancer, there have been various approaches to enhancing the host immune response...Various strategies have been employed to amplify this immune response to cause enhanced anti-tumor activity."
"Near-infrared (NIR) photoimmunotherapy is designed to selectively destroy target cells. The specificity comes from the monoclonal antibody, which is conjugated to the photo-activating,phthalocyanine-based chemical, IRDye700DX (IR700). Selective cytotoxicity is induced in a modest number of antibody–IR700-bound cells, only when exposed to non-thermal doses of NIR at 690 nm, the activating wavelength for IR700. Upon absorption of this NIR light, a photo-induced ligand-release reaction occurs, which leads to dramatic physical and chemical changes in the conjugated antibody–antigen complex. This, in turn, leads to cell membrane micro-perforations that quickly coalesce into blebs followed by cell rupture.."

 

[rei]

Why use some patented toxin that kills cancer cells, when NIR alone at thermal doses also cures cancer?

 

[Rick K]

Why use some patented toxin that kills cancer cells, when NIR alone at thermal doses also cures cancer?

Follow the money. No profit in cures. I like this bit :"Ever since researchers realized the value of the immune system in the fight against cancer, Ya think?