Lately I have had the great pleasure of briefly meeting this lovely person who was touring around Europe for the summer, she is from the U.S.
We've had great laughs and talked about various things and at some point she mentions that she is prone to motion sickness. My girlfriend has the same issue so we were going back and forth with various solutions to the problem. Coincidentally, she mentions this old fishermen's technique of placing an uncoated aspirin tablet into the belly button and covering it up with a small piece of tape to keep it in place. She proceeds to explain that it's more of an old-wives tale but it seemed to work for her during her travel.
It's an interesting idea and it makes sense viscerally. I was wondering if anyone in here has ever tried this particular route of administration? I might be trying it tonight with one of Haidut's products. A quick search online yielded the following study and a rather promising quote:
http://jpharmsci.org/article/S0022-3549(15)44975-5/pdf
" The data generated (Fig. 1) suggest that administration via the navel yields a relatively faster absorption and also greater systemic bioavailability of [14C]testosterone than administration via the forearm. Both routes of percutaneous absorption give well-defined first-order elimination kinetics, which is very much in parallel to that of intravenous administration. It is interesting to note that the systemic bioavailability of‘ [14C]testosterone by navel absorption is relatively close to the level obtained by the intravenous administration of an equivalent dose and is substantially greater than the level achieved by forearm administration. "
We've had great laughs and talked about various things and at some point she mentions that she is prone to motion sickness. My girlfriend has the same issue so we were going back and forth with various solutions to the problem. Coincidentally, she mentions this old fishermen's technique of placing an uncoated aspirin tablet into the belly button and covering it up with a small piece of tape to keep it in place. She proceeds to explain that it's more of an old-wives tale but it seemed to work for her during her travel.
It's an interesting idea and it makes sense viscerally. I was wondering if anyone in here has ever tried this particular route of administration? I might be trying it tonight with one of Haidut's products. A quick search online yielded the following study and a rather promising quote:
http://jpharmsci.org/article/S0022-3549(15)44975-5/pdf
" The data generated (Fig. 1) suggest that administration via the navel yields a relatively faster absorption and also greater systemic bioavailability of [14C]testosterone than administration via the forearm. Both routes of percutaneous absorption give well-defined first-order elimination kinetics, which is very much in parallel to that of intravenous administration. It is interesting to note that the systemic bioavailability of‘ [14C]testosterone by navel absorption is relatively close to the level obtained by the intravenous administration of an equivalent dose and is substantially greater than the level achieved by forearm administration. "