Natural polyphenols as sirtuin 6 modulators

[David PS]

March 2023
More benefits from blueberries.

Cardiovascular disease protective properties of blueberry polyphenols (Vaccinium corymbosum): a concise review - Food Production, Processing and Nutrition

Increasing epidemiological evidence suggests inverse association between consumption of diets rich in fruits and vegetables and the incidence of cardiovascular diseases (CVD), metabolic syndrome disorders, certain types of cancer, neurodegenerative disorders, and other forms of human chronic...

link.springer.com

 

[David PS]

May 2023

Influence of Polyphenols on Adipose Tissue: Sirtuins as Pivotal Players in the Browning Process

Adipose tissue (AT) can be classified into two different types: (i) white adipose tissue (WAT), which represents the largest amount of total AT, and has the main function of storing fatty acids for energy needs and (ii) brown adipose tissue (BAT), rich in mitochondria and specialized in...

www.mdpi.com

SIRT6​

The main effects of SIRT6 on AT are to regulate the inflammatory process and lipid metabolism. SIRT6 increases the thermogenic function of BAT and browning of sWAT by recruiting the promoter of PGC-1α gene [114,115]. SIRT6 deficiency inhibits browning in WAT following cold exposure or β3-agonist treatment. SIRT6 overexpression in primary adipocytes stimulates thermogenesis by activating PGC-1α expression through phospho-ATF2 (pATF2) [115]. Low UCP1 levels associated with increased adipocyte size were observed in BAT and iWAT from SIRT6-KO mice. The mRNA levels of beige/brown adipocyte marker genes (UCP1, PPARGC-1α, PRDM-16, CIDEA, and Elovl3) were significantly down-regulated in BAT and iWAT from SIRT6-KO mice (Figure 2) [91].

 

[Highserotonin90]

@David PS at what doses has quercetin been shown to activate sirti6 in humans?

 

[David PS]

@David PS at what doses has quercetin been shown to activate sirti6 in humans?

I did not know that quercetin activated sirt6. Can you post your source?