My Log About Intestinal Barrier, Celiac Disease, Environment And Liver

[Broken man]

First, please dont be angry because of my bad english I am trying to learn it by myself and translator. Thank you.

Hello all, due to Ray Peat, I found that we have the power to change our lives. Even I am not agreeing with all Peat ideas, I improved myself alot thanks to him so he will be one of the most influental person which I found.

About this log, it will be mostly about restoring damaged gut barrier ( intestinal barrier), increasing stomach acid, enzymes, changing microbiome, mast cells and all things related to gut. Please, some posts will be non-peaty, be open and dont blame others but of course that I will be happy for every experience or idea.

About myself, I am 21 years old man from Europe. I have celiac disease for about 4 years, problem is that I still have problems even I am on gluten free diet, I tried alot of things but even if I have improvements, its usually no longer than month or so and gut problems are back. I was "peating" for about 1 year with no success but the problem is that I dont have access to ripe fruits, most fruits are imported from other countries and are sprayed with chemicals that make them look fresh and good. Due to stupidity of my country, local fruits are more expensive than imported and my financial situation forced me to use the less expensive option so I dont know if my result with "peat" diet isnt caused by all the chemicals I am in touch with. Next problem that I have with "peat" diet is that its more like first aid when things are going really bad (antibiotics, cyproheptadine...) than long term solution. So I decided to change my diet and supplements to my environment like eating more starches for example and its working. It is possible that "peat" diet is the best diet for optimal health but think about it, its impossible to eat only fruit when somebody is living in Europe (weather changes, most fruits are with alot of fiber like apples etc....). To be honest, I know alot of people which are eating mainly potatoes and are doing good so I think its more about good health that is able to adapt to the environment. After some searching, I think that gut health is the most important thing that relates to strong metabolism, especially gut barrier.

Intestinal Barrier Function: Molecular Regulation and Disease Pathogenesis
Gut barrier in health and disease: focus on childhood. - PubMed - NCBI
Celiac Disease: Role of the Epithelial Barrier

My strategy is targetting intestinal barrier, microbiome, bile and keep liver healthy while doing all this.

I will share my supps that I am taking for now and had success with for long term:
-Probiotics that contain Lactobacillus acidophillus, Lactobacillus rhamnosus, Bifidobacterium longum
- Magnesium malate
- Zinc picolinate
- Phosphatidylcholine (Mitolipin)
- Taurine
- Nicotine through vape ( almost best supplement even some members are against it)
- Caffeine
- Succinic acid

Here I will post some articles and studies about how I found these supplements:
- https://www.sciencedirect.com/scien...bIfF9ivc0J5-t_jlsaPaoCGSmXIqK5lCHCtfl-fl-LbDs
- Nicotine exposure alters in vivo human responses to endotoxin
- Anti-inflammatory effects of nicotine in obesity and ulcerative colitis
- Nicotine and inflammatory neurological disorders
- https://www.ncbi.nlm.nih.gov/pubmed/24298024
- https://aem.asm.org/content/82/14/4...y6OxGFtjfu5U3QdgVhEZwwJsMnJ-CNLkzqTp-u0h_OoD8
- https://medium.com/health-begins-no...bd-and-ibs-how-and-why-they-work-90ad50ee509c
- https://www.naturalmedicinejournal....t-intestinal-permeability-defects-and-related


I will work on this log and like I said, I will be happy if there will be somebody who will give me some feedback or will discuss this topic with me. Thank you all.

 

[Zpol]

I will share my supps that I am taking for now and had success with for long term:
-Probiotics that contain Lactobacillus acidophillus, Lactobacillus rhamnosus, Bifidobacterium longum
- Magnesium malate
- Zinc picolinate
- Phosphatidylcholine (Mitolipin)
- Taurine
- Nicotine through vape ( almost best supplement even some members are against it)
- Caffeine
- Succinic acid

I can tell you one thing about probiotics, specifically L-rhamnosus, and Bifido, they worked great for several months and then quit working. I don't know why. Maybe I should've rotated them. For whatever the reason, they no longer help.

How do you take MitoLipin? oral or topical? How much per day?

What is your experience with Succinic acid? I have been told I have a problem with the succinate pathway by my functional doctor but I didn't understand what this means and what to do about it. Also, Succinic acid chelates minerals; wouldn't it also chelate your zinc?

 

[baccheion]

Iodine protocol is associated with such healing. And megadose vitamin D (+ K2 MK-4 + chelated/TRAACS magnesium; 10 IU D3 : 2 mcg+ MK-4).

 

[somuch4food]

Yeah, I think a strong gut would solve most problems.

I'm focusing on similar things atm. My angle is on optimising sat fat and cholesterol to help support and heal the liver and the gut barrier. I'm not taking any supplements apart from magnesium oil.

Here is an interesting article about cholesterol and its relation to the gut barrier: Part Five: Cholesterol, Leaky Gut, Endotoxemia and Heart Disease

Don't worry about non peaty stuff. There are as many solutions as there are members on this forum.

 

[Broken man]

I can tell you one thing about probiotics, specifically L-rhamnosus, and Bifido, they worked great for several months and then quit working. I don't know why. Maybe I should've rotated them. For whatever the reason, they no longer help.

How do you take MitoLipin? oral or topical? How much per day?

What is your experience with Succinic acid? I have been told I have a problem with the succinate pathway by my functional doctor but I didn't understand what this means and what to do about it. Also, Succinic acid chelates minerals; wouldn't it also chelate your zinc?

Its true that I dont have much benefits from using probiotics but wanted to try them because of studies I saw. I am taking Mitolipin orally because of liver and intestines. Its great for sleep and the best supplement against endotoxin for now.
About succinic acid, I never saw that it is chelating minerals, why doyou think that? I know that its detoxifying for the body. I love succinic acid because it gives me alot of energy and drive to do things but I need to have good liver function or I would be bloated.

 

[Zpol]

About succinic acid, I never saw that it is chelating minerals, why doyou think that? I know that its detoxifying for the body. I love succinic acid because it gives me alot of energy and drive to do things but I need to have good liver function or I would be bloated.

I can't access the linked resource (it gives me a 404 error). I'm pretty sure I accessed it 3 years ago when I was researching, but now all I have is this quote

Peat mentioned heavy metal chelation with "succinic acid as the sodium or
magnesium salt (sodium or magnesium succinate)" a while back:
DMSA and DMPS Toxic?

I bought some magnesium succinate when I first read about it, but never actually tried it.

I also found this on the Immortal hair forum...

"Chelating agents (interview with Dr. Ray Peat, Ph.D.)

There are several methods of mercury (and other heavy metal)
detoxification. If you decide to have your amalgams replaced with
gold, porcelain or composites, choose a dentist who is trained to do
it. Otherwise your symptoms can become much worse or even
life-threatening due to unsafe removal procedures which increase
ingestion of mercury and its vapors. Also, removal of silver
amalgams does not remove body stores. These must be removed by
chelation therapy. Substances that bind mercury and other metals are
called chelating agents and there are both oral and intravenous
chelation therapies available.

Unfortunately, most chelating substances can have very poisonous
effects. Common chelating agents such as EDTA, used both
intravenously and orally, can remove heavy metals including from the
bone, such as lead. The problem is, after removal from the bones, the
EDTA dumps the lead into the brain and the kidneys. Chemet (succimer,
or 2,3-dimercaptosuccinic acid abbreviated DMSA), is a dangerous
chelating agent which was approved by the FDA in January 1991. DMSA
is very similar to another chelating agent called BAL, or British
Antilewisite (2,3- dimercaptopropanol). The problem is, just like
EDTA, both DMSA and BAL remove lead from the bones and deposit it into
the brain and the kidneys. IF the lead is removed before it gets
into the bones, there is no toxic effect with EDTA, DMSA or BAL but
why use something dangerous? There is a review article in J. of
Chem. Ed., in the early 1970â??s which summarizes the research in 3-4
pages and references the original research.

Estrogen makes you overproduce collagen and stimulates soft tissue
deposition of calcium.

Thyroid makes you retain magnesium and dump abnormal calcium and
estrogen. Thus, thyroid is similar to chelation.

Surfaces of blood vessels work like an ion exchange resin. If you run
calcium over the membranes, the membranes will suck up calcium.

To safely remove heavy metals, use succinic acid as the sodium or
magnesium salt (sodium or magnesium succinate). It is classified as a
food, is an antioxidant (anti-free radicals) and stimulates
respiration in addition to being a chelator. Succinic acid will suck
out Al non-toxically. Magnesium or sodium + succinic acid should
chelate mercury. No side effects.

The last resort is penicillamine. Good for all heavy metals but not
as safe as succinic acid.

According to Dr. Ray Peat, succinic acid as the sodium or magnesium
salt (sodium or magnesium succinate) is the safest chelating agent,
with penicillamine being next. In the 1930â??s, Szent-Gyorgyi showed
that succinate stimulated cell respiration. In the 1980â??s other
researchers reported that it stimulates pregnenolone production in the
adrenal glands. Succinic acid is a good food, is crucial to the Krebs
cycle (essential for energy), speeds it up by stimulating respiration
and is thus similar to the thyroid hormone. Pure succinic acid or
succinate (not DMSA) can be used either orally or intravenously. It
has no harmful effects to the mitochondria (as does EDTA). Succinate
has been shown to remove aluminum and lead. There is no reason not to
believe that it will also take out other heavy metals, including
mercury and iron, but I have no references on this. It would be great
if someone would do a study on this. Peat says succinic acid works
orally so I would choose to do oral rather than intravenous chelation
therapy. His recommended dosage is 200 mg twice daily but please put
the succinic acid in a capsule, otherwise, it will suck calcium out of
your teeth. Peat says that it may take a week or so to clean out the
heavy metals.

Succinate does not suck calcium from the blood, but helps carry it.
Plus, it stimulates respiration and helps deposit calcium in bones
while taking it out of soft tissues. It simulates carbon dioxide
production which increases oxygen in the body. CaCO3 is the starting
material for hydroxyappetite (bone substance).

A high sodium diet (sea salt, not table salt) prevents kidney damage
from heavy metals. Other good chelating agents include, orange juice
and coffee and intravenous (not oral) ascorbic acid. Ascorbate is
better used i.v. than orally because it can irritate the live and the
colon and cause diarrhea. Also, ascorbic acid must be pharmaceutical
grade because most sources are contaminated with heavy metals due to
the method of manufacture. Also 90% of ascorbic acid now comes from
China. The citric acid in orange juice is a good chelator. The
caffeine in coffee helps get the lead and cadmium out of the kidneys.

Succinate and mercury (Hg) , iron (Fe)

Does it remove Hg? Experiments used Al (aluminum). Al behaves the
same as Hg but this is only an assumption. It is proven that
succinate removes Fe.

Toxicity of DMPS and DMSA

Question: Does the body quickly or gradually get rid of DMPS or DMSA
chelating agents? I have many people who nearly died when they took
DMPS or DMSA. But, I should think that the body would eventually
detox it. What do you think?

Dr. Ray Peatâ??s comment:

The idea of using it to remove metals is that it leaves the body
rapidly. The damage produced by moving the metals around could be
fairly permanent, but the chelator leaves very quickly. Environmental
pollutants, food fats, and cosmetics are the things people should
worry about accumulating in their tissues."​

 

[Broken man]

I can't access the linked resource (it gives me a 404 error). I'm pretty sure I accessed it 3 years ago when I was researching, but now all I have is this quote


I also found this on the Immortal hair forum...

"Chelating agents (interview with Dr. Ray Peat, Ph.D.)

There are several methods of mercury (and other heavy metal)
detoxification. If you decide to have your amalgams replaced with
gold, porcelain or composites, choose a dentist who is trained to do
it. Otherwise your symptoms can become much worse or even
life-threatening due to unsafe removal procedures which increase
ingestion of mercury and its vapors. Also, removal of silver
amalgams does not remove body stores. These must be removed by
chelation therapy. Substances that bind mercury and other metals are
called chelating agents and there are both oral and intravenous
chelation therapies available.

Unfortunately, most chelating substances can have very poisonous
effects. Common chelating agents such as EDTA, used both
intravenously and orally, can remove heavy metals including from the
bone, such as lead. The problem is, after removal from the bones, the
EDTA dumps the lead into the brain and the kidneys. Chemet (succimer,
or 2,3-dimercaptosuccinic acid abbreviated DMSA), is a dangerous
chelating agent which was approved by the FDA in January 1991. DMSA
is very similar to another chelating agent called BAL, or British
Antilewisite (2,3- dimercaptopropanol). The problem is, just like
EDTA, both DMSA and BAL remove lead from the bones and deposit it into
the brain and the kidneys. IF the lead is removed before it gets
into the bones, there is no toxic effect with EDTA, DMSA or BAL but
why use something dangerous? There is a review article in J. of
Chem. Ed., in the early 1970â??s which summarizes the research in 3-4
pages and references the original research.

Estrogen makes you overproduce collagen and stimulates soft tissue
deposition of calcium.

Thyroid makes you retain magnesium and dump abnormal calcium and
estrogen. Thus, thyroid is similar to chelation.

Surfaces of blood vessels work like an ion exchange resin. If you run
calcium over the membranes, the membranes will suck up calcium.

To safely remove heavy metals, use succinic acid as the sodium or
magnesium salt (sodium or magnesium succinate). It is classified as a
food, is an antioxidant (anti-free radicals) and stimulates
respiration in addition to being a chelator. Succinic acid will suck
out Al non-toxically. Magnesium or sodium + succinic acid should
chelate mercury. No side effects.

The last resort is penicillamine. Good for all heavy metals but not
as safe as succinic acid.

According to Dr. Ray Peat, succinic acid as the sodium or magnesium
salt (sodium or magnesium succinate) is the safest chelating agent,
with penicillamine being next. In the 1930â??s, Szent-Gyorgyi showed
that succinate stimulated cell respiration. In the 1980â??s other
researchers reported that it stimulates pregnenolone production in the
adrenal glands. Succinic acid is a good food, is crucial to the Krebs
cycle (essential for energy), speeds it up by stimulating respiration
and is thus similar to the thyroid hormone. Pure succinic acid or
succinate (not DMSA) can be used either orally or intravenously. It
has no harmful effects to the mitochondria (as does EDTA). Succinate
has been shown to remove aluminum and lead. There is no reason not to
believe that it will also take out other heavy metals, including
mercury and iron, but I have no references on this. It would be great
if someone would do a study on this. Peat says succinic acid works
orally so I would choose to do oral rather than intravenous chelation
therapy. His recommended dosage is 200 mg twice daily but please put
the succinic acid in a capsule, otherwise, it will suck calcium out of
your teeth. Peat says that it may take a week or so to clean out the
heavy metals.

Succinate does not suck calcium from the blood, but helps carry it.
Plus, it stimulates respiration and helps deposit calcium in bones
while taking it out of soft tissues. It simulates carbon dioxide
production which increases oxygen in the body. CaCO3 is the starting
material for hydroxyappetite (bone substance).

A high sodium diet (sea salt, not table salt) prevents kidney damage
from heavy metals. Other good chelating agents include, orange juice
and coffee and intravenous (not oral) ascorbic acid. Ascorbate is
better used i.v. than orally because it can irritate the live and the
colon and cause diarrhea. Also, ascorbic acid must be pharmaceutical
grade because most sources are contaminated with heavy metals due to
the method of manufacture. Also 90% of ascorbic acid now comes from
China. The citric acid in orange juice is a good chelator. The
caffeine in coffee helps get the lead and cadmium out of the kidneys.

Succinate and mercury (Hg) , iron (Fe)

Does it remove Hg? Experiments used Al (aluminum). Al behaves the
same as Hg but this is only an assumption. It is proven that
succinate removes Fe.

Toxicity of DMPS and DMSA

Question: Does the body quickly or gradually get rid of DMPS or DMSA
chelating agents? I have many people who nearly died when they took
DMPS or DMSA. But, I should think that the body would eventually
detox it. What do you think?

Dr. Ray Peatâ??s comment:

The idea of using it to remove metals is that it leaves the body
rapidly. The damage produced by moving the metals around could be
fairly permanent, but the chelator leaves very quickly. Environmental
pollutants, food fats, and cosmetics are the things people should
worry about accumulating in their tissues."​

Really thank you for this because it gave me alot of valuable info that I was missing while using succinic acid. User @Travis told me that succinic acid is safe and I didnt find some bad side effects from using it. That is all I can say. For me, succinic acid is really important supplement for energy, focus and drive.

 

[Broken man]

So I will post what I found about:
Goat Milk- https://www.sciencedirect.com/science/article/pii/S0261561405002128
- https://www.physiology.org/doi/full/10.1152/japplphysiol.00295.2003
- Intestinal anti-inflammatory effects of goat whey on DNBS-induced colitis in mice
- Anti-inflammatory and anti-allergic properties of donkey's and goat's milk. - PubMed - NCBI

Ginkgo biloba - Ginkgo biloba extract suppresses endotoxin-mediated monocyte activation by inhibiting nitric oxide- and tristetraprolin-mediated toll-like receptor... - PubMed - NCBI
- Effects of compound Ginkgo biloba on intestinal permeability in rats with alcohol-induced liver injury. - PubMed - NCBI

Type of fat and intestinal inflammation - Ethanol and Dietary Unsaturated Fat (Corn Oil/Linoleic Acid Enriched) Cause Intestinal Inflammation and Impaired Intestinal Barrier Defense in Mice Chronically Fed Alcohol

- The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model... - PubMed - NCBI

Lubiprostone - Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers

Some foods that could help - http://cdn.intechweb.org/pdfs/25358.pdf

Lithium - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560707/

Ethyl Pyruvate - http://jpet.aspetjournals.org/content/304/1/464.short @haidut

 

[Dino D]

How are you doing now?