Mutaflor

Discussion in 'Digestion, Gut Flora' started by Tarmander, Nov 27, 2019.

  1. ecstatichamster

    ecstatichamster Member

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    do you drink milk?
     
  2. OP
    Tarmander

    Tarmander Member

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    nope
     
  3. milkboi

    milkboi Member

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    So, anyone on here with CFS tried this with good results?
     
  4. Blossom

    Blossom Moderator

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  5. dfspcc20

    dfspcc20 Member

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    @Tarmander are you still getting the sleep benefits from Mutaflor?
     
  6. OP
    Tarmander

    Tarmander Member

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    I am

    However I have been messing around with antibiotics so things are a bit all over the place at the moment.

    But mutaflor sleep benefits were working for a couple months before I started messing with other things so its pretty effective for me
     
  7. Mufasa

    Mufasa Member

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    Tarmander

    Tarmander Member

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    That is interesting. Brand new study too.

    I almost stopped reading at this point "There is no real objective evidence for the therapeutic effects of Nissle,"

    But the rest of the article is pretty solid. e. coli nissle produces colibactin. They inject colibactin into intestinal cells and find gene mutations.

    Looking around I also found this which explains a bit more how e. coli product colibactin: Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety - Chemical Science (RSC Publishing)!

    But back to the original study, it was pretty big! 20 million dollar funding. It has hit all the major news sources as well. I wouldn't be surprised if you started seeing Mutaflor sales drop.

    Initially I am thinking that use of Mutaflor should be restricted to those who benefit from it. Having decades of constipation resolve itself may be worth the extra cancer risk. And obviously it is a small part of the colorectal cancer picture with only around 5% of colorectal cancers showing signs (A common gut microbe secretes a carcinogen - Hubrecht Institute) of damage from colibactin.

    My other thought is that Mutaflor may displace other strains of worse E. Coli. Perhaps after an extended course of mutaflor, taking antibiotic substances known to kill e. coli would then get rid of all the e. coli you have and youd be better off.

    There is still evidence that healthy e. coli helps people with auto immune and chronic conditions. Maybe this is a trade off that we now need to be aware of.

    I will be interested to see how this study is treated in the coming months. 20 million is a lot to put into a study like this, and I am wondering if there are financial interests that will be revealed.
     
  9. Guacamayo

    Guacamayo Member

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    @ecstatichamster So are you still taking the Mutaflor still, and if not, why did you stop? I mean, if it was having such a great effect in relieving your constipation?

    You mentioned that you were taking 4 a day, was that in the morning, daytime, or at night, and was that with meals or away from meals (and how many hours away from meals)?

    Also, I know it was mentioned somewhere in this thread, but how long can this probiotic last without refrigeration? I'm getting mine shipped to me, and even though it's packed with an ice pack, it'll still spend a day or two outside the fridge.

    @Tarmander You have to remember that it's really only those who have a reduced amount of E Coli in their gut biome who would stand to gain any benefits from Mutaflor. If you already have adequate levels of E Coli, pounding yourself with more....especially for 5 months which is what they did in the study (from memory I think it's meant to be cycled every few months)...well that's just a recipe for disaster.
     
  10. ecstatichamster

    ecstatichamster Member

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    still taking mutaflor. 2 twice daily usually after eating. They say it lasts five days at room temperature without losing much efficacy.
     
  11. OP
    Tarmander

    Tarmander Member

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    I stopped taking Mutaflor for a month or so to work on other protocols

    The last week my sleep started to get a little worse, I noticed I was waking at 6am and having a bit of a strung out feeling for the first couple hours of the day

    This all culminated with the last couple days waking at 5am, feeling low blood sugar, being wide awake, despite only getting 5-6 hours of sleep.

    Yesterday popped a couple mutaflor in the morning and that night slept 8-9 hours, woke up at 7am. Works like a charm.
     
  12. ecstatichamster

    ecstatichamster Member

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    I’m taking about 4 per day and finding that the constipation is better. I’m having two bowel movements a day, although they are a bit like the rabbit pellets, but still not terrible and I am not taking any cascara, and some days I”m not having fruit and still doing okay. So I would say it is still a benefit.
     
  13. Moondancer

    Moondancer New Member

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  14. ecstatichamster

    ecstatichamster Member

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    Welcome to Ray Peat Forum, @Peg Sheridan

    Enjoy!

    Thanks for the link. I believe that is @Tarmander’s podcast, and it is always excellent.
     
  15. thomas00

    thomas00 Member

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    After reading this thread, there is no way I would take this stuff.
     
  16. Aladdin

    Aladdin New Member

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