MPB Experimental Treatments

[Inaut]

I am really interested in the idea of topical mildronate. Should work like caffeine/aspirin but also it would work like minoxidil .

I could buy the tablets and send them to someone to experiment with.

Curious to see if it does anything.

 

[Inaut]

anybody ever think to try a methyl salicylate camphor+menthol liniment oil on the bald areas? I was browsing for camphor as a result of @johnwester130 's post about mildronate and stumbled on to a pain rub oil... Just thinking out loud. I like camphor a lot

https://www.amazon.com/Efficascent-Oil-100ml-Strength-Counterirritant/dp/B00O5B7RCE

 

[johnwester130]

anybody ever think to try a methyl salicylate camphor+menthol liniment oil on the bald areas? I was browsing for camphor as a result of @johnwester130 's post about mildronate and stumbled on to a pain rub oil... Just thinking out loud. I like camphor a lot

https://www.amazon.com/Efficascent-Oil-100ml-Strength-Counterirritant/dp/B00O5B7RCE

what is the mechanism of action though ?

 

[Kunstruct]

I have seen recently two women with Male Pattern Baldness. Considering how quickly women use wigs, not sure exactly why those weren't wearing wigs.
For those who said that castration is the solution... for MPB might have to think again.

 

[Progesterone]

I have seen recently two women with Male Pattern Baldness. Considering how quickly women use wigs, not sure exactly why those weren't wearing wigs.
For those who said that castration is the solution... for MPB might have to think again.

Most likely low estrogen and/or progesterone

Estrogen and Hair Loss: What is the Connection? - Hair Science

 

[Pufa]

honestly, I have taken topical progesterone for years before quitting. I had everything, about 5 jars from onasnatural, the idealabs product too.

I don't think it works at all.

Did you try adding dhea to it like ray suggests for topical hair application?

 

[ilhanxx]

A Comparative Study between Topical 5% Minoxidil and Topical "Redensyl, Capixyl, and Procapil" Combination in Men with Androgenetic Alopecia

A Comparative Study between Topical 5% Minoxidil and Topical

with minox 24 weeks

Hızlı Resim - Cosmetology Trichology Alopecic Areas 5 137 G007

with rcp treatment

Hızlı Resim - Cosmetology Trichology Frontal Area 5 137 G003

 

[Pufa]

A Comparative Study between Topical 5% Minoxidil and Topical "Redensyl, Capixyl, and Procapil" Combination in Men with Androgenetic Alopecia

A Comparative Study between Topical 5% Minoxidil and Topical

with minox 24 weeks

Hızlı Resim - Cosmetology Trichology Alopecic Areas 5 137 G007

with rcp treatment

Hızlı Resim - Cosmetology Trichology Frontal Area 5 137 G003

Never heard of it.. but very impressive results. Which brand do you use?

 

[Kunstruct]

Most likely low estrogen and/or progesterone

Estrogen and Hair Loss: What is the Connection? - Hair Science

I have a friend which is in her early 30s.
She started shedding and it looks like the temples are quickly going away.
He general mood is generally high stress and unfortunately often hysteria. I do not know seems like bipolar, times seems to also lack empathy.

She did some blood work a months apart.
Turns out 80-90 Prolactin levels constantly, which is high, one could say she is breast feeding, but no, never she had any kids.
Secondly her Estradiol is 300-400, very high.
Testosterone non-existent for females, DHT non-existent.
Thyroid very good.
Progesterone to the ground, almost non-existent.

Her grandma had Male Pattern Baldness, very advanced, basically bald the way a man would be, not the Female Pattern Baldness, but her grandma was not the agitated stressful type of person, at least did not manifest that way.

So here you see via the bloodwork:
No Androgens
Very high E2
No Progesterone
Very high Prolactin

 

[Progesterone]

I have a friend which is in her early 30s.
She started shedding and it looks like the temples are quickly going away.
He general mood is generally high stress and unfortunately often hysteria. I do not know seems like bipolar, times seems to also lack empathy.

She did some blood work a months apart.
Turns out 80-90 Prolactin levels constantly, which is high, one could say she is breast feeding, but no, never she had any kids.
Secondly her Estradiol is 300-400, very high.
Testosterone non-existent for females, DHT non-existent.
Thyroid very good.
Progesterone to the ground, almost non-existent.

Her grandma had Male Pattern Baldness, very advanced, basically bald the way a man would be, not the Female Pattern Baldness, but her grandma was not the agitated stressful type of person, at least did not manifest that way.

So here you see via the bloodwork:
No Androgens
Very high E2
No Progesterone
Very high Prolactin

Yeah.

As per the link I posted, in women it's often related to estrogen, or progesterone. In this case, estrogen dominance, and very low prog.

 

[johnwester130]

Did you try adding dhea to it like ray suggests for topical hair application?

yes, i had dhea powder dissolved in a cream. it has benefits as a beauty cream, but not a baldness cure.

At the moment, I am considering a topical of Mildronate and Acetazolamide so that my hair follciles are using glucose. I don't like to use hormones that much anymore

 

[brix]

yes, i had dhea powder dissolved in a cream. it has benefits as a beauty cream, but not a baldness cure.

At the moment, I am considering a topical of Mildronate and Acetazolamide so that my hair follciles are using glucose. I don't like to use hormones that much anymore

did you end up trying pyruvate on the scalp?

 

[johnwester130]

did you end up trying pyruvate on the scalp?

havent received it yet

i will experiment with it

 

[Pufa]

yes, i had dhea powder dissolved in a cream. it has benefits as a beauty cream, but not a baldness cure.

At the moment, I am considering a topical of Mildronate and Acetazolamide so that my hair follciles are using glucose. I don't like to use hormones that much anymore

Yeah better off avoiding using hormones unless truly needed. I'm not sure but I get the impression Ray's general advices are geared towards older population

 

[johnwester130]

I have a friend which is in her early 30s.
She started shedding and it looks like the temples are quickly going away.
He general mood is generally high stress and unfortunately often hysteria. I do not know seems like bipolar, times seems to also lack empathy.

She did some blood work a months apart.
Turns out 80-90 Prolactin levels constantly, which is high, one could say she is breast feeding, but no, never she had any kids.
Secondly her Estradiol is 300-400, very high.
Testosterone non-existent for females, DHT non-existent.
Thyroid very good.
Progesterone to the ground, almost non-existent.

Her grandma had Male Pattern Baldness, very advanced, basically bald the way a man would be, not the Female Pattern Baldness, but her grandma was not the agitated stressful type of person, at least did not manifest that way.

So here you see via the bloodwork:
No Androgens
Very high E2
No Progesterone
Very high Prolactin

this is the peat beginner guide to lower stress

Simple Newbie Guide To Peat's Work :

topically, Solban would be helpful for a female

 

[Tristan Loscha]

Hmmmm..

androgens are hightening ROS production;N-acetyl cysteine,which increases Glutathion-production and liberation,
is inhibiting androgeninducible TGF-β1.
Thoughts?

Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
Hyoseung Shin, Hyeon Gyeong Yoo, Shigeki Inui, Satoshi Itami, In Gyu Kim, A-Ri Cho, Dong Hun Lee, Won Seok Park, Ohsang Kwon, Kwang Hyun Cho, Chong Hyun Won
BMB reports 46 (9), 460, 2013
The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgeninducible TGF-β1 was significantly suppressed by the ROSscavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs.[BMB Reports 2013; 46 (9): 460-464]

 

[johnwester130]

my experiment will be :

50ml alcohol

1 gram acetazolamide
1 gram mildronate dissolved in

applied topically.

this creates approximately a 2% solution. I'm ready to begin

 

[Pufa]

my experiment will be :

50ml alcohol

1 gram acetazolamide
1 gram mildronate dissolved in

applied topically.

this creates approximately a 2% solution. I'm ready to begin

cool let us know how it goes. do you think eating a high glucose low fat diet would help with that process too?

 

[johnwester130]

cool let us know how it goes. do you think eating a high glucose low fat diet would help with that process too?

In peat's articles, he always mentions burning sugar instead of fat is better. So yes.

 

[Zigzag]

There's one experimental drug coming developed by Bayer. It targets PRLR. They already tested it on macaques with VERY GOOD results. We'll see.