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Moxonidine (New Generation Clonidine)

  1. As I'm struggling with excess noradrenaline and adrenaline load on my body, I found this drug Moxonidine. (I couldn't access Clonidine)

    It's a second generation alpha 2/imidazoline 1 receptor agonist antihypertensive drug just like Clonidine. Unlike clonidine, moxonidine acts more on imidazoline receptor, it's weaker on alpha 2 receptor.

    Here take a look
    • MOX decreases plasma noradrenaline and adrenaline levels significantly
    • MOX suppresses both TLR4 and TGF Beta. Helps in the treatment of liver fibrosis.
    • MOX can be used for diabetes/insulin problems. Even on the treatment of metabolic syndrome. It improves glycaemic control and insulin sensitivity. Obese patients has decreased body weight through the treatment with MOX.
    • As a anti-hypertensive it decreases systolic and diastolic blood pressure, improves cardiovascular health, can even reverse heart muscle hyperthropy.
    • It's (not powerfully) sedative. Might be helpful for sleeping especially if you are stressed with adrenaline and noradrenaline just like me.
    • It has some neuroprotective effects.
    • Safe: No side effects, no withdrawal

    The use of moxonidine in the treatment of hypertension. - PubMed - NCBI
    The I1-imidazoline agonist moxonidine decreases sympathetic tone under physical and mental stress
    [The efficacy and safety of moxonidine in patients with metabolic syndrome (the O.B.E.Z.I.T.A. trial)]. - PubMed - NCBI
    Activation of imidazoline I1 receptor by moxonidine regulates the progression of liver fibrosis in the Nrf2-dependent pathway. - PubMed - NCBI
    Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice. - PubMed - NCBI
  2. Did you try it?
  3. I used it for a while. Before bed, helps sleeping..
  4. I found with regular clodinine i would fall asleep but feel like I haven't slept at all
  5. A legally available substance called Agmatine should be considered here! It has been identified as a clonidine displacing substance, and shares very similar properties to Clonidine. It is simply decarboxylated arginine.

    I have tried it in various dose ranges - 100mg - 1g. It is very theraputic and promotes neurogenesis, akin to ketamine; also it shares properties with memantine, a substance that haidut has mentioned.
  6. how did you get a hold of moxonidine? I can't see it on the usualy pharmacy websites.