As I'm struggling with excess noradrenaline and adrenaline load on my body, I found this drug Moxonidine. (I couldn't access Clonidine)
It's a second generation alpha 2/imidazoline 1 receptor agonist antihypertensive drug just like Clonidine. Unlike clonidine, moxonidine acts more on imidazoline receptor, it's weaker on alpha 2 receptor.
Here take a look
- MOX decreases plasma noradrenaline and adrenaline levels significantly
- MOX suppresses both TLR4 and TGF Beta. Helps in the treatment of liver fibrosis.
- MOX can be used for diabetes/insulin problems. Even on the treatment of metabolic syndrome. It improves glycaemic control and insulin sensitivity. Obese patients has decreased body weight through the treatment with MOX.
- As a anti-hypertensive it decreases systolic and diastolic blood pressure, improves cardiovascular health, can even reverse heart muscle hyperthropy.
- It's (not powerfully) sedative. Might be helpful for sleeping especially if you are stressed with adrenaline and noradrenaline just like me.
- It has some neuroprotective effects.
- Safe: No side effects, no withdrawal
The use of moxonidine in the treatment of hypertension. - PubMed - NCBI
The I1-imidazoline agonist moxonidine decreases sympathetic tone under physical and mental stress
[The efficacy and safety of moxonidine in patients with metabolic syndrome (the O.B.E.Z.I.T.A. trial)]. - PubMed - NCBI
Activation of imidazoline I1 receptor by moxonidine regulates the progression of liver fibrosis in the Nrf2-dependent pathway. - PubMed - NCBI
Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice. - PubMed - NCBI
Did you try it?