More good news on Ivermectin....

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Peatness

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Ivermectin-induced wound healing

Mechanisms of ivermectin-induced wound healing - PubMed (nih.gov)

Abstract​

Background: Wounds cause structural and functional discontinuity of an organ. Wound healing, therefore, seeks to re-establish the normal morphology and functionality through intertwined stages of hemostasis, inflammation, proliferation, and tissue remodelling. Ivermectin, a macrolide, has been used as an endectoparasiticide in human and veterinary medicine practice for decades. Here, we show that ivermectin exhibits wounding healing activity by mechanisms independent of its well-known antiparasitic activity. This study aimed to evaluate the wound healing property of ivermectin cream using histochemistry and enzyme-linked immunosorbent assay techniques.

Results: Non-irritant dose of ivermectin cream (0.03-1%) decreased wound macroscopic indices such as exudation, edge edema, hyperemia, and granulation tissue deposition by day 9 compared to day 13 for the vehicle-treated group. This corresponded with a statistically significant wound contraction rate, hydroxyproline deposition, and a decreased time to heal rate. The levels of growth factors TGF-β1 and VEGF were significantly elevated on day 7 but decreased on day 21. This corresponded with changes in cytokines (IL-1α, IL-4, IL-10, and TNF-α) and eicosanoids (LTB4, PGE2, and PGD2) levels on days 7 and 21.. Interestingly, low doses of ivermectin cream (0.03-0.1%) induced wound healing with minimal scarring compared to higher doses of the cream and the positive control, Silver Sulfadiazine.

Conclusion: Ivermectin promotes wound healing partly through modulation of the inflammatory process and the levels of Transforming Growth Factor-Beta 1 and Vascular Endothelial Growth Factor. Low doses of ivermectin cream have the potential to be used in treating wounds with minimal scar tissue formation.
 

Missenger

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Dewormers have some interesting properties regarding chronic wounds, Israel was probably onto something with that.
 

Ben.

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Interesting how antiheminthics (febendazole in combination with vitamin e succinat for cancer for example) have interactions beyond taking care of worms. It just goes to show that that is the case with basicly anything that we put in our body. Good or bad.

Idk where i read it but some guy somewhere suggested when taking antibiotics, it would make sense to take a dewormer/antifungal aswell to make sure neither of thoose gets a opportunity to overgrow ... but i guess its not that simple.
 
P

Peatness

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Has anyone used liquid ivermectin topically, if so what protocol did you use?
 

Jam

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Pfizermectin, coming soon to a pharmacy near you...


Screenshot 2021-07-30 210415.jpg
 

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