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Abstract said:Background: An astrocyte-associated motor neurone syndrome was produced in molybdenum-deprived sheep fed xanthosine. Mo-deprived sheep fed inosine, adenosine or guanosine would be also expected to develop astrocyte-associated motor neurone syndromes, because all these purine nucleosides can act as neuromodulators and all depend on the Mo-associated enzyme xanthine oxidase-dehydrogenase for their catabolism.
Design: To investigate the relationship between inosine ingestion and low Mo concentration, eight sheep were fed lucerne chaff with a Mo value <0.10 ppm and the Mo antagonist, sodium tungstate, for 21 weeks, with inosine (35 mg/kg/day[*]) fed for the last 18 of these weeks. This clinical study was uncontrolled.
Results: An astrocyte-associated motor neurone syndrome was produced in three sheep 18-27 months later. It was characterised by diaphragmatic, laryngeal, lingual and pharyngeal muscle weakness. The diaphragmatic muscle weakness was the most severe and potentially lethal.
Conclusion: These findings suggest that purinergic neuromodulation of respiration, vocalisation and swallowing is different to that of limb movement. The syndrome produced, and assumed to be caused by the treatment given, has not been reported in livestock. A similar syndrome is seen in human motor neurone disease, but not in equine motor neurone disease, and this is consistent with it being an upper, not a lower, motor neurone effect.
*I think that the body weight to surface area ratio of sheeps isn't too different from ours, it must be alright to consider the same dose for a human.
Cool ps.:
I was searching for tyw's posts on molybdenum, and found this:
Which is exactly what I was trying to convey with these quotes.
You'd have to ask him, but caffeine is only partially (1/3?) metabolized requiring a morbydenum enzyme, whose activity seems to be relatively conserved.When it says they can’t handle coffee, does it mean that it stressed them out too much etc.?
how much molybdenum are you looking to attain?Well not really. A host of natural foods are rich in this element. Oats, lentils navy beans, chickpeas. Problem of course is that these items are horribly estrogenic if one were to eat them in quantities sufficient to obtain a proper amount of Mo.
Following a peat inspired diet will invariably lead to a deficiency. Although Peat has some contrarian ideas regarding the desirability of transition metals in nutrition, iron especially, given its steady accumulation with age, and the attendant metabolic inefficiency. I would not, however rush to conflate these two, Mo and Fe. Undoubtedly some of it is needed to preserve the integrity of the human organism. How much is needed though is unclear to me. Should one just bite the bullet and occasional consume the least worst option among these offenders,in the manner of liver and shellfish, Or supplement. Thoughts?
- Nutrient Metabolism: Structures, Functions, and Genes (978-0-12-387784-0)
Our results indicated Mo at 20 mg/L has a significant therapeutic effect on infertility mice.
The mechanism of Mo therapeutic effect could be Mo could repair the damaged testicular structure, regulate reproductive endocrine, decrease oxidative stress and resist cell apoptosis.
To our knowledge, this is the first report on the offspring birth to term of Mo treating infertility mice.
what does it mean if jaw is clenched? testosterone going up?I took 1mg molybdenum yesterday (first time since a long time) evening and woke up during the night with the jaw clenched. I wonder if both are related.
Effect of molybdenum on reproductive function of male mice treated with busulfan
Infertility is a serious public health problem worldwide. Molybdenum (Mo) plays an important role in maintaining normal metabolism. To explore the the…www.sciencedirect.com
Sorry my message was not clear.what does it mean if jaw is clenched? testosterone going up?