Moderate Doses Of Aspirin Reverse Insulin Resistance

The study was in rats but it has been replicated in humans as well, even though the replication study in humans used much higher doses of aspirin (human dose 90mg/kg). This study used smaller doses of aspirin equivalent to 650mg taken every 6 hours. If this works, it could be a much safer dosing regimen especially for people prone to bleeding.

http://www.jci.org/articles/view/11559

"...Insulin-stimulated whole-body glucose uptake was decreased by 37% with the lipid infusion (Figure 1c). Salicylate pretreatment prevented decreases in insulin-stimulated whole-body glucose uptake caused by lipid infusion. Decreases in insulin-stimulated whole-body glucose uptake were due to a 41% decrease in insulin-stimulated glucose uptake in skeletal muscle (soleus) with lipid infusion (Figure 1d). Salicylate pretreatment also prevented the lipid-induced decrease in insulin-stimulated skeletal muscle glucose uptake. Furthermore, insulin-stimulated whole-body glycolysis and glycogen/lipid synthesis were significantly decreased by 27% and 43%, respectively, with the lipid infusion (Figure 2, a and b). Salicylate pretreatment prevented these decreases in insulin-stimulated whole-body glucose metabolic flux caused by lipid infusion. Similar to the decreases in insulin-stimulated whole-body glucose metabolic flux with lipid infusion, insulin-stimulated skeletal muscle glycolysis was decreased by 36% with lipid infusion (Figure 2c), but the most profound change was a 66% decrease in insulin-stimulated skeletal muscle glycogen synthesis with lipid infusion (Figure 2d). Salicylate pretreatment also prevented the lipid-induced decreases in insulin-stimulated skeletal muscle glucose metabolism."

 

Is there a way to find out if I am prone to bleeding from Aspirin? I am about to experiment with this but not sure if I should just go all out and start on the high doses.

Also, I read in one experiment where they used aspirin for insulin resistance, they found that bicarbonate levels decreased after use of aspirin....any idea why this would be? I thought it should increase...? (reference below)

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

 

Whether you are prone or not, Ray suggests taking 1mg K2 for every tablet of aspirin. Even the moderate doses used in this study can cause bleeding issues.

 

Thanks for your response Haidut. I recently brought up the whole K2 negating Aspirins blood thinning effects with my doctor. He is quite open minded so is open to many of Rays ideas. He told me that there are two ways in which you can clot (and consequently thin) blood. Aspirin thins the blood via a different process, and because of this K2 wont negate that. K2 would on the other hand can stop the thinning caused by Warfarin as Warfarin thins the blood via the same process in which K2 clots it.

He explained the process but it was too technical for me and unfortunately googling this has proven very difficult. Do you have any information on this?

 

He is correct that there are multiple mechanisms for blood thinning but he is NOT correct that vitamin K won't help with aspirin bleeding. IM injections of K1 are given in hospitals to prevent bleeding from aspirin overdose and it works like a charm.

 

Can K2 help with blood thinning in exactly the same way the K1 can?

 

Also warfarin should be taken with k2. K2 helps prevent calcification of arteries caused by warfarin and it does not inactivate or prevent warfarin from working.

 

Yes, all of them can. K2 has the added benefit that it affects arterial calcification unlike K1 which mostly affects coagulation.

 

Haidut, thank you for your responses. I was hoping you could take a look at the new post someone made about Aspirin still thinning blood and shed some light on this. The link is here:

Thorne’s K2 Not Effective At All - Aspirin Still Causing Bleeding

And also the following post where someone discusses the technical details behind what my doctor suggested:

I am wondering if maybe its K1 that needs to be used instead....or does my doctor have a point? Not sure. Thanks in advance for your response!

 

K2 works for me to eliminate bleeding when I take aspirin.

 

May I ask what kind of bleeding? I'm new here, and I'm trying to understand the risks/benefits from taking aspirin. Thanks.

 

a bit of rectal bleeding, a bit of nose bleeding

 

@ecstatichamster- Thanks for the clarification

 

When you say 1mg of K2 per tablet of aspirin, how much assumed to be in 1 tablet of aspirin? Or are all containers of aspirin equal in terms of dosage per tablet?

 

325mg

 

Mine are only like 40 mg per tablet. No wonder I notice no effect from it haha