Mitochondrial Activity May Determine Lifespan

[haidut]

I know Ray has written on the link between metabolism and longevity, and here is a study that corroborates this idea...in worms

https://theconversation.com/predicting- ... orms-23267

The study claims that the rate of production of toxins like NO inside the mitochondria during the first couple of days of life can reliably estimate lifespan of the organism.
It would be interesting to see a study what happens to worms with damaged mitochondria that undergo a restoration therapy with thyroid.

 

[BingDing]

This page, and site, has some related ideas:

the mitochondrial theory of aging


The essay has very good info on the five enzyme complexes and all the steps converting one molecule of glucose to 28-36 molecules of ATP (depending on the theory).

The Wiki page on "theory of aging" has some interesting counter ideas.

 

[haidut]

This page, and site, has some related ideas:

the mitochondrial theory of aging


The essay has very good info on the five enzyme complexes and all the steps converting one molecule of glucose to 28-36 molecules of ATP (depending on the theory).

The Wiki page on "theory of aging" has some interesting counter ideas.

Pretty interesting page. Even more interestingly, one of the recommended compounds for retarding the aging process is the use of dopaminergic drugs, specifically Deprenyl:
"...Miquel, the "co-father" of the MTA, believes deprenyl is a useful modality to increase life span. He states that '...deprenyl attenuates the progressive degeneration of dopaminergic neurons in the nigrostriatum during aging... by mehanisms including a specific protection of mitochondria against respiratory chain-dependent oxygen stress. This is probably due to the fact that, in addition to its direct antioxidant action, deprenyl enhances the activity of mitochondria-protecting SoD and catalase, increases the expression of glutathione peroxidase, and preserves the mitochondrial membrane potential [which is the driving force for ATP production (12)]' (24)."

I wonder if that is another reason why Ray favors the dopaminergic state as opposed to the serotonergic one - increasing dopamine has beneficial effects on mitochondria, rather than just being an "opposite" state of the dreaded serotonin dominance.

 

[Such_Saturation]

Keeping the system just slightly uncoupled kind of makes it impossible for there to be damaging runoff. The high CO2 would shield you from it anyways. This of course would mean your mother eating Peaty since your conception, your father not being stressed before conception, and you living a perfectly monastic life .

 

[Philomath]

I know Ray has written on the link between metabolism and longevity, and here is a study that corroborates this idea...in worms

https://theconversation.com/predicting- ... orms-23267

The study claims that the rate of production of toxins like NO inside the mitochondria during the first couple of days of life can reliably estimate lifespan of the organism.
It would be interesting to see a study what happens to worms with damaged mitochondria that undergo a restoration therapy with thyroid.

If someone did perform such a study, don't expect "theconversation.com" to report on it... The author seems pretty certain that production of toxins/free radicals early in life is useless information to humans -

"Unfortunately, this doesn’t happen in real life. Human beings live much longer lives in spite of producing much less antioxidants compared to rats, hamsters, mice and rabbits. And studies involving dietary supplementation of antioxidants show an inverse relationship between antioxidant levels and life span. The claim that oxidative stress in early life may be a predictor of lifespan may work in some worms but it will certainly be of no use in humans."

Some people are so closed minded!

 

[DaveFoster]

Pretty interesting page. Even more interestingly, one of the recommended compounds for retarding the aging process is the use of dopaminergic drugs, specifically Deprenyl:
"...Miquel, the "co-father" of the MTA, believes deprenyl is a useful modality to increase life span. He states that '...deprenyl attenuates the progressive degeneration of dopaminergic neurons in the nigrostriatum during aging... by mehanisms including a specific protection of mitochondria against respiratory chain-dependent oxygen stress. This is probably due to the fact that, in addition to its direct antioxidant action, deprenyl enhances the activity of mitochondria-protecting SoD and catalase, increases the expression of glutathione peroxidase, and preserves the mitochondrial membrane potential [which is the driving force for ATP production (12)]' (24)."

I wonder if that is another reason why Ray favors the dopaminergic state as opposed to the serotonergic one - increasing dopamine has beneficial effects on mitochondria, rather than just being an "opposite" state of the dreaded serotonin dominance.

Haidut, what are your thoughts on supplementing deprenyl for cognitive enhancement and life extension purposes? The question is open to any one with thoughts on the matter.

 

[haidut]

post 108901

Pretty interesting page. Even more interestingly, one of the recommended compounds for retarding the aging process is the use of dopaminergic drugs, specifically Deprenyl:
"...Miquel, the "co-father" of the MTA, believes deprenyl is a useful modality to increase life span. He states that '...deprenyl attenuates the progressive degeneration of dopaminergic neurons in the nigrostriatum during aging... by mehanisms including a specific protection of mitochondria against respiratory chain-dependent oxygen stress. This is probably due to the fact that, in addition to its direct antioxidant action, deprenyl enhances the activity of mitochondria-protecting SoD and catalase, increases the expression of glutathione peroxidase, and preserves the mitochondrial membrane potential [which is the driving force for ATP production (12)]' (24)."

I wonder if that is another reason why Ray favors the dopaminergic state as opposed to the serotonergic one - increasing dopamine has beneficial effects on mitochondria, rather than just being an "opposite" state of the dreaded serotonin dominance.

Haidut, what are your thoughts on supplementing deprenyl for cognitive enhancement and life extension purposes? The question is open to any one with thoughts on the matter.

Don't have experience with Deprenyl but I posted a study showing anti-serotonin drugs like mianserin and cyproheptadine extended lifespan and serotonergic drugs like SSRI shortened it by 40%. I think a similar life extension ability has found for dopaminergic drugs like bromocriptine.