Minocycline Attenuated The Influence Of Early-life Trauma In Mice

[foodandtheworld]

Effects of Minocycline on Changes in Brain Tryptophan Metabolism and the Behavior of Juvenile Mice Elicited By Inescapable-Predator Stress.

Hideki Miura, Yu Ando , Yukihiro Noda, Norio Ozaki, Kenichi Isobe.
https://www.scitechnol.com/2324-8947/2324-8947-2-107.pdf
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"Conclusion: Minocycline counteracted the stress-induced KYN [kynurenine] pathway and behavioral changes and attenuated the influence of early-life trauma."

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"Because prolonged behavioral and neurochemical changes elicited by PTEs [potentially traumatizing experiences] in early life are known to become more severe in response to stress exposure in adulthood, these changes may suggest vulnerability and a predisposition to psychiatric disease such as depression and anxiety disorder including PTSD. Our present results suggest that minocycline counteracted the activation of the brain KYN pathway and the behavioral disinhibition elicited by inescapable-predator stress exposure in juvenile mice. Thus, minocycline may become a candidate drug to prevent the adult onset of psychiatric disease after exposure to PTEs such as child abuse (physical abuse, psychological abuse, and sexual abuse), neglect, infection, pain, and natural disasters." [bolds mine].

 

[Jared]

Thanks for posting this!