1942 Study-
Observations on induced thiamine deficiency, placed 11 women on diets which provided 0.22 mg. of thiamine for each 1000 calories.
This allowance was five and a half times greater than that given during their earlier studies and was selected to produce a milder type of deficiency compared to that which might be encountered
more frequently in the general population.
Caloric intakes were adapted to the requirements of each subject and moderate activity was permitted.
The periods of low thiamine allowance mere continued for 89 to 196 days
[Symptoms]
During this time all subjects showed definite changes of personality.
Irritable
Depressed
Quarrelsome and uncooperative
Two threatened suicide.
All became inefficient in their work
Forgetful
Lost manual dexterity.
Their hands and feet frequently felt numb.
Headaches
Backaches
Sleeplessness
Sensitivity to noises were noted
The subjects fatigued easily
Constipation was the rule, but no impairment
Anorexia
Nausea
Vomiting
Epigastric distress were frequently observed.
Low blood pressure and vasomotor instability
mere present in all patients.
At rest, pulse rates were low (55 to 6O per minute) but
tachycardia followed moderate exertion.
Fasting blood sugar was often abnormally high.
[Recovery Notes]
When additions of thiamine were made to the diet, the above manifestations disappeared gradually and a sense of well-being returned. Apparent improvement, however, was not so rapid as it had been with the more severe degrees of thiamine deficiency studied.
Observations on induced thiamine deficiency, placed 11 women on diets which provided 0.22 mg. of thiamine for each 1000 calories.
This allowance was five and a half times greater than that given during their earlier studies and was selected to produce a milder type of deficiency compared to that which might be encountered
more frequently in the general population.
Caloric intakes were adapted to the requirements of each subject and moderate activity was permitted.
The periods of low thiamine allowance mere continued for 89 to 196 days
[Symptoms]
During this time all subjects showed definite changes of personality.
Irritable
Depressed
Quarrelsome and uncooperative
Two threatened suicide.
All became inefficient in their work
Forgetful
Lost manual dexterity.
Their hands and feet frequently felt numb.
Headaches
Backaches
Sleeplessness
Sensitivity to noises were noted
The subjects fatigued easily
Constipation was the rule, but no impairment
Anorexia
Nausea
Vomiting
Epigastric distress were frequently observed.
Low blood pressure and vasomotor instability
mere present in all patients.
At rest, pulse rates were low (55 to 6O per minute) but
tachycardia followed moderate exertion.
Fasting blood sugar was often abnormally high.
[Recovery Notes]
When additions of thiamine were made to the diet, the above manifestations disappeared gradually and a sense of well-being returned. Apparent improvement, however, was not so rapid as it had been with the more severe degrees of thiamine deficiency studied.