Mice Lacking Dopamine D4 Receptors Are Supersensitive To Ethanol, Cocaine, And Methamphetamine

[Lokzo]

https://www.cell.com/abstract/S0092-8674(00)80365-7

 

[NewACC]

Hmmm, does this mean that it can be considered a presynaptic dopamine receptor? And why is it called the "novelty receptor"?

 

[NewACC]

I have also seen a study of ultra-low doses of haloperidol (1/20th of the usual) being a completely safe booster of levodopa in people with Parkinson's. It means, it causes hypersensitivity to dopamine. This is also consistent with VERY mixed reports of hypersensitivity to stimulants such as methylphenidate, amphetamine and mdma after even 1 time took at low doses (also 1/20th of the lowest effective dose). Also of interest are studies on the hyperalgesia of ultra-low doses of morphine (~1mcg in human terms) and the SIGNIFICANT potentiation of subeffective doses of morphine by the same ultra low dose of naltrexone(I mean~1-1.5mcg of naltrexone).

 

[NewACC]

@haidut you must comment it!

 

[NewACC]

There is small list of studies:
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis,
View: https://www.reddit.com/r/Stims/comments/3mbp3n/be_very_careful_with_low_doses_of_stimulants/


View: https://www.reddit.com/r/Nootropics/comments/69not1/suffering_from_persistent_dopamine_sensitization

Ultra-low-dose naltrexone suppresses rewarding effects of opiates and aversive effects of opiate withdrawal in rats - PubMed

Ultra-low-dose NTX coadministration blocks the acute rewarding effects of analgesic doses of oxycodone or morphine as well as the anhedonia of withdrawal from chronic administration.

pubmed.ncbi.nlm.nih.gov

Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice - PubMed

In previous studies we showed that low (pM) concentrations of naloxone (NLX), naltrexone (NTX) or etorphine selectively antagonize excitatory, but not inhibitory, opioid receptor-mediated functions in nociceptive types of sensory neurons in culture. Cotreatment of these neurons with pM NTX or...

pubmed.ncbi.nlm.nih.gov

 

[NewACC]

@Hans , @Lokzo , @haidut here?

 

[Lokzo]

@Hans , @Lokzo , @haidut here?

Yes, this thread deserves an update.

 

[NewACC]

@haidut @Hans