allblues
Member
- Joined
- Oct 30, 2015
- Messages
- 225
Found a study on methylxanthine (caffeine, theobromine, theophylline etc) intake and rat testicular/hormonal health. Rats were given one of either of the three substances in what appears to be quite large amounts (0,5% of total diet?)
Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline. - PubMed - NCBI
I'm not too worried as the complete circumstances of diet etc that these rats were under isn't clear, and the dose was probably quite hefty, but i'm interested in the findings which seem contradictory;
First this;
Plasma testosterone shot up but the testicles suffered injury? Did the xanthines just make the poor 'nads work harder than they could manage, busily spitting out T until they just couldn't take it anymore?
Another related study;
Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats. - PubMed - NCBI
Been investigating this stuff as coffee tends to make my own pair regress, but i'm guessing that's probably a blood flow/adrenaline thing.
Anyway, i know you guys love talking steroids so i thought i'd throw this one out there.
Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline. - PubMed - NCBI
I'm not too worried as the complete circumstances of diet etc that these rats were under isn't clear, and the dose was probably quite hefty, but i'm interested in the findings which seem contradictory;
First this;
And then this;... Caffeine and theobromine induced testicular injury in nearly all rats. Theophylline induced severe testicular atrophy in 14 percent of the rats, mild to moderate atrophy in 71 percent, and had no effect in 15 percent. The relative testicular toxicity of the methylxanthines was caffeine, most potent; theobromine, slightly less potent; and theophylline, considerably less potent.
Plasma testosterone concentrations were significantly elevated in the theobromine group and somewhat elevated in the caffeine-treated group; this correlated morphologically with an apparent hyperplasia of interstitial cells in severely atrophied testes in these groups. Plasma cholesterol concentrations were significantly increased in the caffeine and theobromine groups.
Plasma testosterone shot up but the testicles suffered injury? Did the xanthines just make the poor 'nads work harder than they could manage, busily spitting out T until they just couldn't take it anymore?
Another related study;
Maternal caffeine consumption has irreversible effects on reproductive parameters and fertility in male offspring rats. - PubMed - NCBI
Been investigating this stuff as coffee tends to make my own pair regress, but i'm guessing that's probably a blood flow/adrenaline thing.
Anyway, i know you guys love talking steroids so i thought i'd throw this one out there.
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