ddjd
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- Joined
- Jul 13, 2014
- Messages
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Can someone clarify does methylene blue have an effect on glutathione levels
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level.Can someone clarify does methylene blue have an effect on glutathione levels
I don't think it raises glutathione levels, but it does affect the GSSG/GSH ratio (raising), which is another redox marker similar to NAD/NADH, FAD/FADH, and pyruvate/lactate. So, MB basically puts into a more oxidized state. To raise total glutathione levels, supplementing with about 10g glycine for 2 weeks has been shown to work. Some studies combine glycine with NAC as well since both amino acids are components of glutathione, but I think this is not needed as there is already plenty of NAC floating around from muscle catabolism and protein ingestion.
Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body compositi... - PubMed - NCBI
B2 raises Glutathione but it's yellow, not blue, and blue might be your favorite color. Recently, someone mentioned liposomal glutathione in a post. Worth trying, I think.
MB seems to give me some irritability as well as a slight headache...
What theanine helps reduce a hangover?theanine rocks for this
What theanine helps reduce a hangover?
Do you combine it with coffee/caffeine and other foods that had a warning in the oxidal thread? I think 100-200 mcg at once is safer.MB seems to give me some irritability as well as a slight headache...
Do you combine it with coffee/caffeine and other foods that had a warning in the oxidal thread? I think 100-200 mcg at once is safer.
It raises glutathione in hepatocytes and improves the *hyde clearance enzymes a lot. yes. If I take too much too soon I lose the intoxication, it defeats drinking. I thought theanine was a garbage supplement, never would have bought again, but a company accidentally sent me a 1 kilogram bag for free.What theanine helps reduce a hangover?
try taking niacin when that happens. i think that might be symptoms of overmethylation. i know it's not known for it, but i do think that mb methylates. even when i've gotten edgy on it, i still never had blue urine which tells me that my body is using it. btw, i'm pretty sure that i'm an undermethylator.MB seems to give me some irritability as well as a slight headache...
try taking niacin when that happens. i think that might be symptoms of overmethylation. i know it's not known for it, but i do think that mb methylates. even when i've gotten edgy on it, i still never had blue urine which tells me that my body is using it. btw, i'm pretty sure that i'm an undermethylator.
I think @Travis mentioned this possibility in the past.try taking niacin when that happens. i think that might be symptoms of overmethylation. i know it's not known for it, but i do think that mb methylates. even when i've gotten edgy on it, i still never had blue urine which tells me that my body is using it. btw, i'm pretty sure that i'm an undermethylator.
There's thousands of studies dealing with this. Methylation is thought to be mainly a function controlled by cobalamin, folate, pyroxidal, methionine, and niacin. Adenine, a nucleotide, can link with methione to form S‐adenosylmethionine (sulfur‐linked methionine); this is a cofactor for most methylation enzymes, which take the methylgroup and add it to an oxygen or a nitrogen. This can change the properties of neurotransmitters as seen in the case of melatonin (O‐methylserotonin), epinephrine (N‐methylnorepinephrine), and methoxytyramine (O‐methyldopamine). The amount of methylgroups on S‐adenosylmethionine is thought to represent the 'the labile methyl pool,' a mental construct used to represent methylation potential.Can you refer me to any educating literature on methylation? I'm not familiar with that process.
Selenomethionine appears to be an entirely different animal. Methionine causes cell growth by becoming polyamines, but selenomethionine actually inhibits this.wow, thank you so much @Travis you really seem to understand methylation. i just discover that i had sky high serum b12 & folate so i suspect that i under methylate. do you have any advise on what i should do? at the time of the blood work i was taking high doses of iodine(not sure if that means anything) btw, selenomethionine makes me exhausted, does that have something to do with methionine?