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Methylene Blue (MB) Mimics Thyroid - Boosts T4 , Lowers TSH

Discussion in 'Scientific Studies' started by haidut, May 15, 2015.

  1. haidut

    haidut Member

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    These studies show that MB increased the levels of T4 in the blood, and lowered TSH. This may explain some of the beneficial effects of MB on hypothyroid people.

    http://www.ncbi.nlm.nih.gov/pubmed/8624735
    "...Surprisingly, blood thyroxine levels increased consistently in rats after MB treatment. An interaction of MB with thyroid hormone synthesis and/or actions thus should be evaluated. This idea is supported by our observation of an antagonistic action of MB in carbimazole-induced rise in thyroid weight and decrease in thyroxine blood levels. (Ref. 14.)."

    http://www.ncbi.nlm.nih.gov/pubmed/8218149
    "...On the other hand, the prolactin (PRL) increase in the blood after estradiol was inhibited by MB, although the prolactin content in the anterior pituitary was not. Methylene blue alone did not change blood prolactin concentration, but it unexpectedly elevated blood thyroxine levels and this effect was partially inhibited by simultaneous estradiol treatment."

    http://www.ncbi.nlm.nih.gov/pubmed/8711376
    "...MB produced a decrease in adenohypophyseal ascorbic acid content. The blood thyroxine levels increased and the anterior pituitary TSH concentration decreased after MB treatment."
     
  2. narouz

    narouz Member

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    Thanks again, haidut.
    Very interesting.
     
  3. pboy

    pboy Member

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    indeed, I wonder how its working...via what method
     
  4. charlie

    charlie The Law & Order Admin

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  5. OP
    haidut

    haidut Member

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    I posted a few other threads showing MB opposes estrogen and inhibits pituitary function. Ray said that pituitary and thyroid are opposites of each other, when one is overactive it will inhibits the other. So, suppressed pituitary and lower estrogen usually mean better thyroid function.
     
  6. johnwester130

    johnwester130 Member

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    How do you reach the conclusion it mimics thyroid from those studies ?
     
  7. OP
    haidut

    haidut Member

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    It lowered TSH, increased T4, lowers estrogen and prolactin and acted like dopamine. There are studies I posted for each of these effects. Aren't these thyroid-like effects, especially the first two?
     
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