Methylene Blue Makes Me Tired

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Months ago I tried doses higher than 1mg. I didn't feel any nootropic affects, but I felt mao-i affect for sure. I suffer for mild anxiety and mild depression. And in about third day I felt very nice affect, I felt calm, when I smelt perfumes I remembered some nice things from past etc. But soon this positive changes disappeared and I felt tired. 1 week after stopping it things went back to normal again.

Since then I make 2 more trial, but with 50mcg daily. On first day I really noticed nootropic affect. But this lasted only for 2 days. After that I started to be more tired again and I didn't feel any nootropic affect or anything else anymore, I was just more tired.

I felt similar tiredness feeling also with other trials of (each one trial as separate and not together):
-b12 injections
-st. john's wort (years ago I felt fantastic on it, lately I feel tired on it)
-apple vinegar
-indian snakeroot
-germanium

Could be that some kind of herx reaction for such small dose (50mcg)? I was also thinking if 50mcg daily can cause methylation problems but then niacin didn't make any improvement. Any idea what else could be?
 
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I suspected serotonin toxicity for long time. But then I tried multiple times indian snakeroot (Reserpine) which depletes serotonin and each time I felt more tired.
 
EMF Mitigation - Flush Niacin - Big 5 Minerals

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