Methylene Blue Is Amazing

[Dave Clark]

5.0 micro mol was the highest effective dose in the skincare studies, above is detrimental. 2.5mM was roughly the most effective concentration.
Buy a high quality MB solution like from Health Natura, Ideallabs or Mitolab and add it to a cream. MB is water soluble and can easily be mixed into water based creams/emulsion. But you need to calculate the concentration. Physiologyweb or sigam have good calculators. Only iniscule amounts are needed![/QUOTE
Thanks for the info, I will try to calculate. Was hoping someone had a stock formula, i.e. one drop of methylene blue (noting concentration) to 4 oz of lotion/skin cream, for instance.

 

[Dave Clark]

Thanks for the reply, I will try to calculate. Was hoping someone had a stock formula, i.e. one drop of MB (noting concentration) to 4 oz of lotion/skin cream, for instance.

 

[accelerator]

Been dabbling with MB for about 3 weeks, been mostly a positive experience, but insomnia has been a thing 3 out of the last 5 days so i guess it’s time for a break. It has really done things for my fatigue though which I’ve struggled with over a year now. Also interest in things like music and people has been up which is big thing for me. Other oddities have been greatly increased nicotine tolerance, increased interest in food, especially pork cravings. (?) My hands and feet have been colder during MB use, especially with coffee. Writing this on iPhone in middle on of the night after failed attempt sleeping so spacing is probably dreadful. Really bummed on the insomnia, nothing previously tried has been this notably helpful. Wonder what might be causing it. EDIT; forgot dose, 0,5 mg at noon or earlier/day

Did it continue to help with brain fog and muscle strength?

Methylene Blue in 1% milk + oj + GL Collagen Hydrosolate= Wow. WTF. Just great. I have been experimenting with Haiduts Oxidal for a few days now (between 3-7 drops a day) and will come back to you threefold if you cut out the coffee on those days. I did take a caffeine pill with it one day (250 mg) but frankly, with enough caloric intake(pretty much just oj and milk, between 2000-3000 calories worth) ..I have felt simply fantastic.

Do you still do this, or was it a one time thing?

 

[lampofred]

Is it a good or bad thing if you get absolutely no effects from high-dose methylene blue? I took 16 milligrams (pretty large dose) of Health Natura's MB, and I experienced no increase in heart rate or temperature, no change in fingernail color to reflect any change in circulation, no change in alertness, nothing at all to suggest my metabolism is switching from glycolysis to oxidative phosphorylation.

I have a lot of lactic acid soreness and other signs of excess glycolysis, so I thought MB would help, but I guess my mitochondria are so damaged that even 16 mg isn't enough to cause a shift to oxidative phosphorylation...?

 

[Progesterone]

Is it a good or bad thing if you get absolutely no effects from high-dose methylene blue? I took 16 milligrams (pretty large dose) of Health Natura's MB, and I experienced no increase in heart rate or temperature, no change in fingernail color to reflect any change in circulation, no change in alertness, nothing at all to suggest my metabolism is switching from glycolysis to oxidative phosphorylation.

I have a lot of lactic acid soreness and other signs of excess glycolysis, so I thought MB would help, but I guess my mitochondria are so damaged that even 16 mg isn't enough to cause a shift to oxidative phosphorylation...?

bump

 

[lampofred]

bump

I don't really know what it's doing. But when I don't use it I feel like crap. So that's the update lol.

 

[Progesterone]

I don't really know what it's doing. But when I don't use it I feel like crap. So that's the update lol.

How long you been using it? dosage? brand? how do you use it?

I find its best used dropped on tongue directly, not in liquid.

 

[MetabolicTrash]

Some have said this raises serotonin and gives you energy/alertness/etc., and well ... that may not be a good thing (it brings some specifics to mind).

The first thing this makes me think of is possibly a recipe for disaster for some at some point. Whenever I anticipate something completely "picking me up" the next thing I wonder is how long until there's some sort of "swing back effect" and I end up eventually feeling the opposite of lifted up/stronger/more clarity/etc. (like how some people depend on caffeine/cigarettes/other drugs/stimuli/"fast lane living"/etc. to not be mellowed out and fall in to possible depression/a need to pick themselves up without the so many stimuli they live on literally).

Just look at examples of anti-depressants -- meant to reduce depression, but many times can actually spiral back in to even more depression. Caffeine is also something I fear for this reason, i.e., feeling a little "slow" on energy and then using a pick me up, which then spins in to more adrenaline then more anxiety then serotonin and this and going together with stress to fuel me and etc. and etc. over days/weeks/months. Not bashing on coffee/caffeine or such, as I used to be an energy drink "junkie" and I'm not attributing all of any issues I've had with caffeine alone, but it can be more harmful than helpful sometimes. I still don't quite feel comfortable at this point with getting back in to more caffeine because it can impact nervous system/stress hormones/anxiousness/etc. At my "heaviest use" I would go at least like 6 days a week with 200-400mg caffeine per day on average -- but sometimes more (almost always energy drinks, but not bashing on them specifically either).

What I'm trying to say here is that it's not always good that something immediately "just works" and picks you up because instant gratification, well ... you know my point. You can find that something makes you feel mighty/gets you up and going for some time, but then the crash/swing back might gradually step in for some. Sooner or later, some find that that very "pick me up" ended up being what dragged them down beneath their baseline when prior to using it for the first time.

I used to "run on stress hormones" as is a known thing on here, literally running on adrenaline, PUFAs, energy drinks/caffeine, and tons of junk food calories/soy/processed meats/crap/etc. When I crashed down and got myself back up slowly without the overeating/mental blocks/etc., I found my baseline energy was much lower, but still aiming to get it up more without "running on stress hormones" or solely on caffeine or such.

I don't hate caffeine or any supplement or thing particularly in this regard -- but some people should absolutely not regularly depend on external "pick me up" things as what can happen is you depend on it so long and once you try and tone it down, you end up with panic/anxiety/depression/etc. when feeling more "normal" and not heavily juiced on caffeine/stress/serotonin/etc. Caffeine for example is something I from now on would only use "sparingly" more than regularly -- at least for now. I don't want to get myself hyped up and moving about too much to end up bedridden and suffering for days with zero drive/etc. months down the line whenever I may decide to cut it out cold turkey. You know something is addictive/more negative than positive when not doing it for 24+ hours severely agitates/stresses/causes discomfort.

 

[Progesterone]

Some have said this raises serotonin and gives you energy/alertness/etc., and well ... that may not be a good thing (it brings some specifics to mind).

The first thing this makes me think of is possibly a recipe for disaster for some at some point. Whenever I anticipate something completely "picking me up" the next thing I wonder is how long until there's some sort of "swing back effect" and I end up eventually feeling the opposite of lifted up/stronger/more clarity/etc. (like how some people depend on caffeine/cigarettes/other drugs/stimuli/"fast lane living"/etc. to not be mellowed out and fall in to possible depression/a need to pick themselves up without the so many stimuli they live on literally).

Just look at examples of anti-depressants -- meant to reduce depression, but many times can actually spiral back in to even more depression. Caffeine is also something I fear for this reason, i.e., feeling a little "slow" on energy and then using a pick me up, which then spins in to more adrenaline then more anxiety then serotonin and this and going together with stress to fuel me and etc. and etc. over days/weeks/months. Not bashing on coffee/caffeine or such, as I used to be an energy drink "junkie" and I'm not attributing all of any issues I've had with caffeine alone, but it can be more harmful than helpful sometimes. I still don't quite feel comfortable at this point with getting back in to more caffeine because it can impact nervous system/stress hormones/anxiousness/etc. At my "heaviest use" I would go at least like 6 days a week with 200-400mg caffeine per day on average -- but sometimes more (almost always energy drinks, but not bashing on them specifically either).

What I'm trying to say here is that it's not always good that something immediately "just works" and picks you up because instant gratification, well ... you know my point. You can find that something makes you feel mighty/gets you up and going for some time, but then the crash/swing back might gradually step in for some. Sooner or later, some find that that very "pick me up" ended up being what dragged them down beneath their baseline when prior to using it for the first time.

I used to "run on stress hormones" as is a known thing on here, literally running on adrenaline, PUFAs, energy drinks/caffeine, and tons of junk food calories/soy/processed meats/crap/etc. When I crashed down and got myself back up slowly without the overeating/mental blocks/etc., I found my baseline energy was much lower, but still aiming to get it up more without "running on stress hormones" or solely on caffeine or such.

I don't hate caffeine or any supplement or thing particularly in this regard -- but some people should absolutely not regularly depend on external "pick me up" things as what can happen is you depend on it so long and once you try and tone it down, you end up with panic/anxiety/depression/etc. when feeling more "normal" and not heavily juiced on caffeine/stress/serotonin/etc. Caffeine for example is something I from now on would only use "sparingly" more than regularly -- at least for now. I don't want to get myself hyped up and moving about too much to end up bedridden and suffering for days with zero drive/etc. months down the line whenever I may decide to cut it out cold turkey. You know something is addictive/more negative than positive when not doing it for 24+ hours severely agitates/stresses/causes discomfort.

It only may raise serotonin at high dosages, like 5mg+

 

[MetabolicTrash]

It only may raise serotonin at high dosages, like 5mg+

That's good to know then. Serotonin can be "demonic" and not exactly always the "happy" stuff associated with it. Best to keep it low-ish than high-ish overall probably. Careful with OJ even since there's evidence it can affect serotonin too much, along with many other things. Finding the right balance on everything can take a long time.

Anyways, I wouldn't personally use this stuff as there's a whole host of other things that can possibly achieve what it does anyways. Even sodium/salt alone can be considered nootropic-ish and give some people some good energy with no crash/side-effects. I definitely feel better at times with just more salt now that I'm more "Peaty."

 

[Progesterone]

That's good to know then. Serotonin can be "demonic" and not exactly always the "happy" stuff associated with it. Best to keep it low-ish than high-ish overall probably. Careful with OJ even since there's evidence it can affect serotonin too much, along with many other things. Finding the right balance on everything can take a long time.

Anyways, I wouldn't personally use this stuff as there's a whole host of other things that can possibly achieve what it does anyways. Even sodium/salt alone can be considered nootropic-ish and give some people some good energy with no crash/side-effects. I definitely feel better at times with just more salt now that I'm more "Peaty."

You might want to listen to this first

 

[lampofred]

How long you been using it? dosage? brand? how do you use it?

I find its best used dropped on tongue directly, not in liquid.

since last oct/nov. probably around 1 mg via mouth which is how much Dr. Peat recommends (3 drops of .4 mg but not all will absorb probably). health natura.

i think it has been improving brain function over time, also my cholesterol has gone up from being at a dangerously low value, and I think MB might be responsible. but i don't notice any nootropic effects immediately after taking it, even though i do just start to get agitated in general if i stop taking it for several days.

 

[Progesterone]

since last oct/nov. probably around 1 mg via mouth which is how much Dr. Peat recommends (3 drops of .4 mg but not all will absorb probably). health natura.

i think it has been improving brain function over time, also my cholesterol has gone up from being at a dangerously low value, and I think MB might be responsible. but i don't notice any nootropic effects immediately after taking it, even though i do just start to get agitated in general if i stop taking it for several days.

Daily usage for almost a year?

Healthnatura brand is 100mcg per 1 drop, so you take approx 10 drops, right?

I notice being able to breathe easier, a few moments after taking it.

 

[lampofred]

Daily usage for almost a year?

Healthnatura brand is 100mcg per 1 drop, so you take approx 10 drops, right?

I notice being able to breathe easier, a few moments after taking it.

Probably going to use it for the rest of my life as long as I can get it... Like I said my situation with it is really weird lol. I don't notice anything no matter how much I take (aside from blue urine) but if I don't take it for a few days I feel noticeably worse, more agitated in general, just an overall malaise. Probably anti learned helplessness or something. One noticeable effect is that is turns off my desire to watch porn. Aside from that, I don't know what it's doing to me but it's my favorite supplement, as weird as that sounds.

No I thought it was 400 mcg per drop, I take 3 drops. I'll look again though.

 

[MetabolicTrash]

Daily usage for almost a year?

Healthnatura brand is 100mcg per 1 drop, so you take approx 10 drops, right?

I notice being able to breathe easier, a few moments after taking it.

Nasal breathing? That seems to be my issue -- can't breathe well through my nose a lot of the time.

Then again I have a history of bad posture and shallow breathing/etc.

I really can't breathe very well through my nose or mouth -- just generally better with my mouth I guess.

Do you regularly breathe poorer and this helps? Or does it just induce a better breathing habit in general?

 

[Progesterone]

Nasal breathing? That seems to be my issue -- can't breathe well through my nose a lot of the time.

Then again I have a history of bad posture and shallow breathing/etc.

I really can't breathe very well through my nose or mouth -- just generally better with my mouth I guess.

Do you regularly breathe poorer and this helps? Or does it just induce a better breathing habit in general?

Not sure if it helps to clear any passages or anything, just that I tend to breathe deeply as soon as it starts 'kicking in' after a dose, and that's how I know it's kicked in.

Cordyceps in high doses and for a long time, is very similar feeling. Actually, if you're looking for something for better breathing, I'd recommend that, too.

 

[Progesterone]

Probably going to use it for the rest of my life as long as I can get it... Like I said my situation with it is really weird lol. I don't notice anything no matter how much I take (aside from blue urine) but if I don't take it for a few days I feel noticeably worse, more agitated in general, just an overall malaise. Probably anti learned helplessness or something. One noticeable effect is that is turns off my desire to watch porn. Aside from that, I don't know what it's doing to me but it's my favorite supplement, as weird as that sounds.

No I thought it was 400 mcg per drop, I take 3 drops. I'll look again though.

Very interesting. Why such high dosages exactly? It has a hormetic dose response.. lower dose = good, higher dose = not as good, typically.

How are your erections? (no homo)

Asking as you are using quite high dosages...

BTW, I have to ask; how is your scalp hair on MB? Helping? Hurting? No change?

It's been confirmed now, in rats, when Mitochondria dysfunction is reversed, wrinkles and hair comes back.

Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function. - PubMed - NCBI

Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function.

 

[lampofred]

Very interesting. Why such high dosages exactly? It has a hormetic dose response.. lower dose = good, higher dose = not as good, typically.

How are your erections? (no homo)

Asking as you are using quite high dosages...

BTW, I have to ask; how is your scalp hair on MB? Helping? Hurting? No change?

It's been confirmed now, in rats, when Mitochondria dysfunction is reversed, wrinkles and hair comes back.

Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function. - PubMed - NCBI

Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function.

I thought 1 mg was a pretty low dose. That's what I read Peat recommended. 15 mg was recommended for depression and you had to go into 100s of mg for the MAO inhibition effect.

It hasn't affected my erections, the only thing that does is endotoxin.

I haven't noticed any positive effects on scalp hair, but it's surely not doing any damage. MB is actually one of the things Peat recommended for MPB because he says high nitric oxide production is a cause of hair loss.

And if restoring mitochondria is the cure to restoring hair, it'd probably be worth a shot to try piracetam.

 

[Progesterone]

I thought 1 mg was a pretty low dose. That's what I read Peat recommended. 15 mg was recommended for depression and you had to go into 100s of mg for the MAO inhibition effect.

It hasn't affected my erections, the only thing that does is endotoxin.

I haven't noticed any positive effects on scalp hair, but it's surely not doing any damage. MB is actually one of the things Peat recommended for MPB because he says high nitric oxide production is a cause of hair loss.

And if restoring mitochondria is the cure to restoring hair, it'd probably be worth a shot to try piracetam.

You need to read this user experience on MB, if you haven't yet. My experience using methylene blue : Nootropics

 

[lampofred]

You need to read this user experience on MB, if you haven't yet. My experience using methylene blue : Nootropics

Good read. Yeah my experience is not as extreme but similar. I don't notice any effects upon dosing but I have noticed an improvement in cognitive function over the past several months and I feel noticeably worse if I stop using it. I'll probably start using only a drop then instead of 3, since he saw results with such a small amount. It'll make my bottle last 3 times as long.