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Methylene Blue For The Brain: Sustained-attention, Short-term Memory, Enhanced Memory Retrieval

  1. New reference for Methylene Blue.

    Press coverage: Old drug may offer new answers in the fight against Alzheimer's

    Purpose: To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain.

    Results: Administration of methylene blue increased response in the bilateral insular cortex during a psychomotor vigilance task (Z = 2.9–3.4, P = .01–.008) and functional MR imaging response during a short-term memory task involving the prefrontal, parietal, and occipital cortex (Z = 2.9–4.2, P = .03–.0003). Methylene blue was also associated with a 7% increase in correct responses during memory retrieval (P = .01).

    Conclusion: Low-dose methylene blue can increase functional MR imaging activity during sustained attention and short-term memory tasks and enhance memory retrieval.

    Pubmed: Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain. - PubMed - NCBI

    Source: RSNA Publications Online
  2. @haidut - For your review to add to the Oxidal reference list if relevant.
  3. Thanks, it's good to see others are also keeping up with the news on MB :):
  4. I can't seem to find the dose of MB they used. It just keeps stating "low-dose".
  5. @ejalrp, it's on page 3 of the PDF: "Then, 13 participants (the methylene blue group) were randomized to receive 280 mg (approximately 4 mg/kg) of oral U.S. Pharmacopeia-grade methylene blue (methylthioninium chloride USP; PCCA, Houston Tex), [...]"
  6. Hardly low-dose :>)
  7. Yes, Haidut has commented on that in the other thread discussing the study. ;)

    Rodriguez et al. contrast low- vs. high doses as follows:

    "The 280-mg dose selection was estimated as 4 mg/kg for an average body weight of 70 kg. Methylene blue is a memory-enhancing drug in animals and humans after a single dose in the low-dose range of 0.5-4 mg/kg, but it has opposite effects at doses greater than 10 mg/kg and displays a hormetic dose response (15)."