New reference for Methylene Blue.
Press coverage: Old drug may offer new answers in the fight against Alzheimer's
Purpose: To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain.
Results: Administration of methylene blue increased response in the bilateral insular cortex during a psychomotor vigilance task (Z = 2.9–3.4, P = .01–.008) and functional MR imaging response during a short-term memory task involving the prefrontal, parietal, and occipital cortex (Z = 2.9–4.2, P = .03–.0003). Methylene blue was also associated with a 7% increase in correct responses during memory retrieval (P = .01).
Conclusion: Low-dose methylene blue can increase functional MR imaging activity during sustained attention and short-term memory tasks and enhance memory retrieval.
Pubmed: Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain. - PubMed - NCBI
Source: RSNA Publications Online
@haidut - For your review to add to the Oxidal reference list if relevant.