Methylene Blue Fail Alzhemiers Trial - (No It Didn't)

haidut

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No it didn't. It failed in people who were also taking officially approved drugs for AD, most of which are cholinergic and thus very very toxic. In the people who were NOT taking any other drugs methylene blue worked.
"...But in a perplexing twist, the drug did show a significant benefit in about 15 percent of patients in the trial who were not taking other standard Alzheimer's drugs, according to the findings released on Wednesday at the Alzheimer's Association International Conference in Toronto."

Once again, classic Big Pharma manipulation - combine a good drug with a bad one and when there is no benefit claim the good drug is also bad and thus kill any incentive for further research.
 

schultz

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Once again, classic Big Pharma manipulation - combine a good drug with a bad one and when there is no benefit claim the good drug is also bad and thus kill any incentive for further research.

This makes me sad :(
 

CoolTweetPete

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Unbelievable level of corruption and moral bankruptcy these companies are engaged in.

Thanks for finding the truth in there, Haidut.
 
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ken

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Interestingly, most of the subjects that benefited were in eastern European study sites. Apparently they aren't getting what we call standard care. Forbes says that another alzheimer trial had it's most positive results there also.
 

whodathunkit

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@ken, you really need to change your avatar. Yer makin' me hungry. :D
 
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ken

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Shrimp wonton with barbecue duck.
 

haidut

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Interestingly, most of the subjects that benefited were in eastern European study sites. Apparently they aren't getting what we call standard care. Forbes says that another alzheimer trial had it's most positive results there also.

The only clinical site I see in Eastern Europe is in Croatia and it is small. Here is the official list:
Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild Alzheimer's Disease - Full Text View - ClinicalTrials.gov

Do you have another list of sites? I know there are a lot of trials going on in Eastern Europe but I don't know of any using methylene blue.
 
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ken

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Sorry, no. I was reading an article on the Forbes site weave-success-from-failed-trial Basically others commenting and taurx responding.
 
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ken

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Fifteen percent of the nine hundred in the trial is about 135 subjects. Although taurx says they have another trial that the results have not been released.
 

Drareg

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Hospital consultants currently treat alzheimer patients with the mindset of being more manageable for caregivers,somehow the caregivers/family believe the consultant is trying to stabilise the decline.

I know of a consutant who treats alzheimer patients and also is a heart "specialist" ,sees around 150 patients possibly more, throws random pills at everyone. He has been asked 4 times by the family as to why he treats with serotonin enhancing pills when he has not once checked serotonin levels in the blood, "we don't generally do that", yet at the start they claim to give a full blood work up,.
When asked to measure hormones a similar response, "we don't really know the levels of progesterone and other hormones for elderly patients". They check T4 and have no interest in anything else thyroid related.

Said consultant gives zero fcuks and remains stoic as balls at all times while dishing out the latest snake oil,goes sailing at weekends, sociopath.
 

haidut

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Fifteen percent of the nine hundred in the trial is about 135 subjects. Although taurx says they have another trial that the results have not been released.

I think it's 15% of the total number of trial patients were not taking any drugs for AD. In those patients methylene blue showed great benefit, and I think it was all of them. So, it's not the same as saying MB only worked for 15% of patients. Also, we need to know the response rate in the placebo group but I suspect there was no placebo group as it would be "unethical".
 
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Dean Hartley, director of science initiatives at the Alzheimer’s Association, says there are multiple reasons that the result might not hold up. The TauRx investigators got their result not by comparing patients who took no other drugs and received LMRX to those who took no other drugs and received placebo, but instead to the entire placebo group. This may have led to better statistical significance, he says, but “was not the appropriate way to analyze that.” It’s also possible that patients who were not receiving other Alzheimer’s medicines may have had improvements in their overall medical care that could explain the brain atrophy differences.
 

haidut

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Hospital consultants currently treat alzheimer patients with the mindset of being more manageable for caregivers,somehow the caregivers/family believe the consultant is trying to stabilise the decline.

I know of a consutant who treats alzheimer patients and also is a heart "specialist" ,sees around 150 patients possibly more, throws random pills at everyone. He has been asked 4 times by the family as to why he treats with serotonin enhancing pills when he has not once checked serotonin levels in the blood, "we don't generally do that", yet at the start they claim to give a full blood work up,.
When asked to measure hormones a similar response, "we don't really know the levels of progesterone and other hormones for elderly patients". They check T4 and have no interest in anything else thyroid related.

Said consultant gives zero fcuks and remains stoic as balls at all times while dishing out the latest snake oil,goes sailing at weekends, sociopath.

That's pretty much the attitude of every doctor I have ever met. The ones that do care initially very quickly get hardened as it is impossible to make money and pay off your loans unless you prescribe pills like a dealer. Those are also the ones that commit suicide about a decade into the practice - i.e. the ones who initially cared and got callous. The sociopaths seemingly do fine initially but have much higher rate of cancer than the general population and are much less likely to survive it. Look up death stats on older doctors - these are generally the sociopaths who survived the "pill mill" initially - they pretty much all died from cancer. Having sociopathic attitude is very pro-cancer, probably due to the serotonergic dominance. Unfortunately, altruism and generosity are associated with CVD and suicide due to the stress these people endure from our modern absolutely sick society.
 

Drareg

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That's pretty much the attitude of every doctor I have ever met. The ones that do care initially very quickly get hardened as it is impossible to make money and pay off your loans unless you prescribe pills like a dealer. Those are also the ones that commit suicide about a decade into the practice - i.e. the ones who initially cared and got callous. The sociopaths seemingly do fine initially but have much higher rate of cancer than the general population and are much less likely to survive it. Look up death stats on older doctors - these are generally the sociopaths who survived the "pill mill" initially - they pretty much all died from cancer. Having sociopathic attitude is very pro-cancer, probably due to the serotonergic dominance. Unfortunately, altruism and generosity are associated with CVD and suicide due to the stress these people endure from our modern absolutely sick society.

This guy gets 250 euros per hour from working and welfare classes desperate for help.

Some good people caught up in medicine that wanted to do good, definition of the archetype heroes,sacrificing a lot for helping others for insurance and legislation to strangle them into submission.

I fully understand why Peat wants to see it destroyed, it's toxic.
 

narouz

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Is this the study where they were taking 30mgx3/day and 60mgx3/day (and also some higher doses, I think, and the 60mgx3/day was the most effective)...?
 

haidut

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Is this the study where they were taking 30mgx3/day and 60mgx3/day (and also some higher doses, I think, and the 60mgx3/day was the most effective)...?

Actually the study did not have a true placebo group, as the placebo group also got MB. So, the active group got 200mg (100mg x 2 daily) and the placebo group got 8mg daily. The 8mg MB is within the range of 5mg - 15mg found curative for depression and even psychosis, so I am not sure how it can even count as placebo. This could very well explain the benefit seen in the placebo group as well since lower doses MB are actually more beneficial for metabolism. The effect of higher doses is more related to oxidizing hypoxic tissue and converting NADH back to NAD. But the optimal effect on mitochondria is seen from 100nM concentrations, which are achievable with <5mg daily. But, to the scientists' credit, it is hard to design placebo that will color urine and body parts like MB.

Experimental: TRx0237 200 mg/day Drug: TRx0237 200 mg/day
TRx0237 100 mg tablets will be administered twice daily.
Placebo Comparator: Placebo Drug: Placebo
Placebo tablets will be administered twice daily. The active placebo tablets include 4 mg of TRx0237 as a urinary and fecal colorant to maintain blinding; hence the placebo group will receive a total of 8 mg/day of TRx0237.
 

Regina

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No it didn't. It failed in people who were also taking officially approved drugs for AD, most of which are cholinergic and thus very very toxic. In the people who were NOT taking any other drugs methylene blue worked.
"...But in a perplexing twist, the drug did show a significant benefit in about 15 percent of patients in the trial who were not taking other standard Alzheimer's drugs, according to the findings released on Wednesday at the Alzheimer's Association International Conference in Toronto."

Once again, classic Big Pharma manipulation - combine a good drug with a bad one and when there is no benefit claim the good drug is also bad and thus kill any incentive for further research.
Dear Haidut, I wrote to you about the elderly Mother rat who developed rapid alzheimer's and severe edema after she was administered ferrous sulfate. Subsequently, I found your interview regarding Dementia. I took notes wrt your recommendations to start: aspirin, MB, niacinamide, pregnenolone, progesterone, DHEA, taurine, saturated fats, K2 (MK-4) and the A,D,E, K2 synergy. As well, I was since able to read voluminous amounts of your amazing insights here. :): And see that this is the best place to follow. I look forward to trying estroban, energin and others and report feedback on the Mother rat's progress. However, I learned that my lab assistants continue to feed PUFA, ensure, honeywheat bread, club crackers, deli meats. So, I'll have to work on controlling the experiment better. Thank you.
 

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