Endocrinologist
Member
- Joined
- Mar 22, 2016
- Messages
- 11
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I found the full text of this study.they use it as dye right?how much MB is need for that concentrations?i hope its not apply to ray's low dose of 1mg.
Haidut wrote in another thread that concentrations of 100 nM/L (nano!) are achieved by taking around 1 mg methylene blue daily. (Why Is Everyone Dramatically Under-dosing Methylene Blue?)
I found the full text of this study.
"However, illumination of cells with WL [white light] in the presence of 15 mM (0.5%) MB caused a significant elevation of DNA strand breaks (5.838 versus 30.91%; P , 0.01) in OE33 cells. [...] Reducing the MB concentration 10-fold (1.5 mM) caused a significant (P , 0.001) reduction in the amount of DNA damage induced when illuminated with WL when compared to that of 15 mM (0.5%) MB illuminated by WL, in terms of both strand breaks and FPG-sensitive sites (Figure 1A, P , 0.001). Furthermore, the amount of DNA damage arising from incubation with solutions of MB at concentrations equal to or ,1.5 mM were not significantly different from the control samples either maintained in the dark or illuminated in WL in the absence of dye (Figure 1A)."
If I understand this right, they used a o.5% solution (5 mg/mL), the same solution that was used in a study they referenced (full text in Portuguese). In this study they first removed excess mucus with n-acetylcysteine, then sprayed the methylene blue solution, and finally removed excess methylene blue with distilled water.
Haidut wrote in another thread that concentrations of 100 nM/L (nano!) are achieved by taking around 1 mg methylene blue daily. (Why Is Everyone Dramatically Under-dosing Methylene Blue?)
In light of this study, could that mean that applying methylene blue topically (i.e. 1 or 2 drops), and then shining red light in that area may be dangerous for the localised cells?
they use it as dye right?how much MB is need for that concentrations?i hope its not apply to ray's low dose of 1mg.
whatDNA damage and aptotosis is one of the main reasons why MB+light is popular in studies. It doesn't necessarily mean that it is bad. Coffee and I'm sure many other supplements can have the same effect.
Awh ***t!Warning: Taking large doses of laboratory chemicals causes problems.
I prefer nocotinic acid :) Live for the flush!
not sure if your serious about that, but niacin form is not safe in long term,at least in comparing to niacinamide.it can cause diabete like problems by increasing free fatty acids.I prefer nocotinic acid :) Live for the flush!