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Methylene Blue And Cyproheptadine?

Discussion in 'Methylene Blue' started by Steveig84, Mar 3, 2016.

  1. Steveig84

    Steveig84 Member

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    Hey Guys,

    Anyone have any information on the combination of low dose Methylene Blue (2 drop Oxidal) and low does Cyproheptadin 2-4mg taken on the same day not at the same time? any reason to avoid this?
     
  2. ecstatichamster

    ecstatichamster Member

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    You are not supposed to take them together, because methylene blue is an MAO inhibitor, and ciproheptidine is to be avoided when you're taking an MAO inhibitor.
     
  3. OP
    Steveig84

    Steveig84 Member

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    thanks for clearing that up, this is what i thought i just wanted to check i was understanding what i was reading correctly!
     
  4. haidut

    haidut Member

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    The avoidance of taking cyproheptadine with MAO-A inhibitors is because cyproheptadine will lower/eliminate the effects of the MAO-A inhibitors, which is considered undesirable by doctors but is exactly what you want in this case.
     
  5. OP
    Steveig84

    Steveig84 Member

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    Haidut are you saying there is nothing to worry about? what do you mean with in this case? because of the low dosage or because of the reason behind the MB/ Cypro usage? as i understand it the MAO-A inhibitory effect of MB isn't the important mechanism in the context of raising metabolism.
     
  6. haidut

    haidut Member

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    What I am saying is that it is exactly the opposition of cyproheptadine to MAO-A inhibition that makes it desirable to take with MB. Riboflavin may be a safer choice since MAO-A is a riboflavin dependent enzyme and taking riboflavin may negate the inhibitory effects of MB on MAO-A.
     
  7. johnwester130

    johnwester130 Member

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    methylene blue inhibits MAO

    cypro promotes MAO

    what happens ?
     
  8. DaveFoster

    DaveFoster Member

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    @Such_Saturation Thinks that methylene blue potentiates the anti-histamine effect of cyproheptadine, which can lower blood pressure. Do you think this is an issue in sub-milligram doses, or do you stand by your previous post?
     
  9. Such_Saturation

    Such_Saturation Member

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    Wha- :shock: (sorry, my memory not so good)
     
  10. haidut

    haidut Member

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    Methylene blue is known to raise blood pressure, and in fact this is why a lot of people do not want to use it. I think you'd need a dose of 5mg or more per pop to get this effect but even 1mg dose can do it sometimes. Things that oppose NO can initially raise blood pressure. I still think the advice for not takin MB with cypro is due to their perceived mutual antagonism in regards to the serotonin system.
     
  11. DaveFoster

    DaveFoster Member

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    I see; it should be fine then. I've taken both in the past with no ill effects.
     
  12. LeeLemonoil

    LeeLemonoil Member

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