Methylation Levels Can Predict Breast Cancer Risk

[haidut]

Related to my post on the BRCA genes and breast cancer risk, this study found out that overmethylation of certain genes associated with stem cell differentiation predicts breast cancer risk across the board and not just for women with faulty BRCA1 gene. In simpler words - Ray Peat seems to be right again. Reduced ability of cells to differentiate caused by overmethylation (inhibition) of genes involved in differentiation is a causative factor in developing breast cancer.

http://www.healthline.com/health-news/b ... isk-070114

"...The genes in question are involved in helping stem cells to differentiate. Stem cells can divide endlessly and become any type of cell the body might need. If this process goes awry and these super-cells start working against the body instead of for it, the result is cancer. Although the exact process is unknown, methylation of these genes is linked to higher rates of cancer."

 

[pboy]

doesn't caffeine increase methylation?

 

[haidut]

doesn't caffeine increase methylation?

According to this study it actually reduces methylation, just as well as bursts of concentric exercise. Again, agreeing with Peat on all fronts.

http://www.sciencedaily.com/releases/20 ... 131254.htm

"...The DNA changes in question are known as epigenetic modifications and involve the gain or loss of chemical marks on DNA over and above the familiar sequence of As, Gs, Ts, and Cs. The new study shows that the DNA within skeletal muscle taken from people after a burst of exercise bears fewer chemical marks (specifically methyl groups) than it did before exercise. Those changes take place in stretches of DNA that are involved in turning "on" genes important for muscles' adaptation to exercise. When the researchers made muscles contract in lab dishes, they saw a similar loss of DNA methyl groups. Exposure of isolated muscle to caffeine had the same effect."

 

[jyb]

It would be interesting to quantity the amount of demethylation for a comparison between one day's coffee consumption, one exercise session, half a gram of niacinamide...and try to compare those to the amount needed to reverse a major methylated handicap (eg, some stress condition inheritated from birth through epigenetics).

 

[haidut]

It would be interesting to quantity the amount of demethylation for a comparison between one day's coffee consumption, one exercise session, half a gram of niacinamide...and try to compare those to the amount needed to reverse a major methylated handicap (eg, some stress condition inheritated from birth through epigenetics).

Good idea. There are some whole body methylation tests available, but none of the major companies are offering it so you'd have to buy it yourself and it probably is not covered by insurance. Here is one:
http://www.seekinghealth.com/methylatio ... -data.html

 

[Such_Saturation]

It would be interesting to quantity the amount of demethylation for a comparison between one day's coffee consumption, one exercise session, half a gram of niacinamide...and try to compare those to the amount needed to reverse a major methylated handicap (eg, some stress condition inheritated from birth through epigenetics).

Yes! I think it's sort of our duty as Peaters. Also, doesn't vitamin A also work with stem cell differentiation?

 

[pboy]

so does this mean it would be wise not to consume methamphetamine?

 

[Such_Saturation]

It would be interesting to quantity the amount of demethylation for a comparison between one day's coffee consumption, one exercise session, half a gram of niacinamide...and try to compare those to the amount needed to reverse a major methylated handicap (eg, some stress condition inheritated from birth through epigenetics).

Yes! I think it's sort of our duty as Peaters. Also, doesn't vitamin A also work with stem cell differentiation?

Here's another thread by haidut where vitamin A inhibits breast cancer viewtopic.php?f=3&t=3213&p=38107