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Metergoline - Serotonin Antagonist & Dopamine Agonist For R&D

Discussion in 'IdeaLabs' started by haidut, Oct 7, 2016.

  1. Constatine

    Constatine Member

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    I must say metergoline has by far become my rat's favorite supplement. It makes him a whole lot more cheerful and lowers inhibitions dramatically. It is a strange occurrence though as he doesn't really notice lowered inhibitions until after events have happened and he is able to think back on his actions. My rat feel much more alive of metergoline, emotions flow more freely, thoughts are more clear, and his perspective has never been better. The only problematic aspect of metergoline is that it makes one aware of much more, this is of course not inherently negative but it can make one more aware of negative situations in one's life. Though I must state that this is only negative when such a situation can not be changed.
     
  2. Quality

    Quality Member

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    Hi constatine thanks for the update, my metergoline is still is in the closet after my rats first dose i decided to wait a bit before trialing it further.
    Good to hear that your rat is having such a good experience with it so far, how has the dosing been so far? how long have you been using it for in total now? did you take days of it? how is your concern with serotonin receptors upregulation as pointed out earlier in this thread.
     
  3. Constatine

    Constatine Member

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    I have been using it every other day for a little over a month now. Typically 4 drops in a dose. As for serotonin receptor upregulation it was my understanding that serotonin receptors really only upregulate due to stressful events (cortisol increases) and estrogen increases. I read that lisuride and some other serotonin antagonists, but not metergoline, downregulated serotonin receptors. This means that serotonin antagonists do not necessarily upregulate serotonin receptors...though we know metergoline does not downregulate receptors. I am also taking DHT raising substances and DHT downregulates most 'bad' serotonin receptors in the brain so I am not too worried about this.
     
  4. dilantinoid

    dilantinoid Member

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    @hiadut

    one should wait the entire 2 weeks before drawing any conclusions with MB in treating Bipolar Depression type 2 for my rat?
     
  5. OP
    haidut

    haidut Member

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    Can you please ask this question in the MB threads? I don't think it has anything to do with metergoline.
    Thx in advance.
     
  6. jaakkima

    jaakkima Member

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    It's out of stock, will it be restocked soon?
     
  7. OP
    haidut

    haidut Member

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    Hopefully by middle of next week. Waiting on a shipment to be sent from the vendor tomorrow.
     
  8. Quality

    Quality Member

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    Posted a few pages ago by someone else:
    Withdrawal from chronic treatment with metergoline, dl-propranolol and amitriptyline enhances serotonin receptor mediated behaviour in the rat
    Withdrawal from chronic treatment with metergoline, dl-propranolol and amitriptyline enhances serotonin receptor mediated behaviour in the rat

    Still not have been using the rest of my metergoline so far, but I think it has the potential to make people more sensitive to the effects of social interaction,psychedelics and mdma type substances (5ht1a, 5ht2a upregulation/sensitivity), add in an HDAC inhibitor such as sodium butyrate/resistant starch/clostridium butyricum and wonderfull things might happen. Ofcourse this is just still a theory.
     
  9. Constatine

    Constatine Member

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    Interesting. I would hope that DHT would be able to nullify this effect.
     
  10. Quality

    Quality Member

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    Doesnt necesarrily have to be bad, if the 5ht1a autoreceptor upregulates aswell, which is like the GATE to letting serotonin that would be a good thing, would mean less serotonin overall, anyway it would probably be a dose/duration dependant curve.
     
  11. chispas

    chispas Member

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    Does metergoline or any other similar ergot derivative other than cypro have an antihistamine action?
     
  12. OP
    haidut

    haidut Member

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    Did you search the forum before asking? That question has been discussed before, including inside this thread.
     
  13. chispas

    chispas Member

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    Yes, nothing came up in this thread except for something about naltrexolone.
     
  14. OP
    haidut

    haidut Member

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  15. chispas

    chispas Member

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  16. OP
    haidut

    haidut Member

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    One suggestion I have is to use both Google and the forum search box for searching. Google is a bit better at "guessing" what you are looking for when you don't know the exact keywords. So, you can do a search using Google like this: "site:raypeatforum.com X Y Z...". The X, Y, Z are keyword you want to search for. So, in case it would be "site:raypeatforum.com lisuride histamine" or "site:raypeatforum.com metergoline histamine". There is no quotes when you type this in Google.
     
  17. chispas

    chispas Member

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    Thanks for that, that's a great tip. Searching skills are definitely necessary in this day and age.
     
  18. khan

    khan Member

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  19. OP
    haidut

    haidut Member

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    Yes, and tianeptine and ondansetron have also showed benefit which suggests many other serotonin antagonists should be able to help. So, even using the BCAA/tyrosine combo may help reduce symptoms.
     
  20. khan

    khan Member

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    Thanks haidut.
     
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