1. Cocoa Butter - Organic & Fair Trade Certified
    CLICK HERE!
    Dismiss Notice
  2. **NEW** BL11 - Orange, Red & Infrared Therapy Body Light
    CLICK HERE!
    Dismiss Notice
  3. Orange & Red Light Therapy Device - LGS1
    CLICK HERE!
    Dismiss Notice

Metergoline - Liquid Serotonin Antagonist For Lab/R&D

Discussion in 'IdeaLabs' started by haidut, Oct 7, 2016.

  1. ravensburger

    ravensburger Member

    Joined:
    Jun 14, 2017
    Messages:
    13
    Gender:
    Female
    4mg for 3 days now.
    First two days were rough - anxious fatigue, flu-like symptoms, foggy brain, a big depressed, uncomfortable digestion.

    Today, pulse (finally!), has risen to 75 bpm after breakfast. Nothing else has made this happen. Nothing.
    Extremely warm feet and hands (again, nothing else has helped this).
    Positive mood, very calm and relaxed --digestion feeling strong.
     
  2. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    1,684
    @haidut do you know specifically which of the 5ht2 receptors metergoline antagonises.

    For instance in the lisuride page you wrote that lisuride is a 5ht2a and 5ht2c antagonist.

    I suspect metergoline doesn't antagonise the 5ht2a receptor but maybe the 'b' or 'c' receptor it does.

    I remember you saying that the fact that lisuride stops the hallucinagenic effects of LSD is proof that it's antagonising the 5ht2a receptor. Would metergoline also stop hallucinogenic effects of LSD?

    Thanks
     
  3. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    1,684
    Does this mean drinking alcohol can cause long term damage to 5ht2c receptors?
     
  4. Stryker

    Stryker Member

    Joined:
    Oct 24, 2013
    Messages:
    243
    You know those days were your field of view is more narrow , bright light is irritating , you can't focus quickly on minute details and eye contact causes anxiety

    I don't feel that way all the time just intermittently and yeah it goes hand in hand with other symptoms of low dopamine .

    Metergoline over time reduces these things for me
     
  5. Stryker

    Stryker Member

    Joined:
    Oct 24, 2013
    Messages:
    243
    4-5 days I think
     
  6. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    12,713
    Gender:
    Male
    Location:
    USA / Europe
    I think metergoline is an antagonist across the entire 5-HT2 and as such would stop an LSD trip.
     
  7. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    12,713
    Gender:
    Male
    Location:
    USA / Europe
    I think they are all about equally effective, but I like metergoline best simply because it does not seem to have any serotonergic residual effects unlike the other ergots.
     
  8. ecstatichamster

    ecstatichamster Member

    Joined:
    Nov 21, 2015
    Messages:
    3,448
    I'm using one drop per day and it seems calming and to help me feel better. More seems to make me too sleepy.
     
  9. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    1,684
    As in hair shedding? What else causes this for you?
     
  10. Pointless

    Pointless Member

    Joined:
    Apr 13, 2016
    Messages:
    796
    Gender:
    Male
    My hair is always shedding. I don't remember exactly how Metergoline affected it.
     
  11. ecstatichamster

    ecstatichamster Member

    Joined:
    Nov 21, 2015
    Messages:
    3,448
    stopped. It made me too sleepy.
     
  12. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    1,684
    @haidut is there any possibility of metergoline raising adrenaline?
     
  13. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    12,713
    Gender:
    Male
    Location:
    USA / Europe
    Possibly, if it raises dopamine too much. Adrenaline is a downstream metabolite.
     
  14. tomisonbottom

    tomisonbottom Member

    Joined:
    Apr 17, 2013
    Messages:
    813
    Can Metergoline be taken at the same time as MB?

    And/or are there any contraindications for metergoline with other peaty supplements such as aspirin, cypro, etc?

    Would ALT, AST and ALP be sufficient for establish good enough liver function for Metergoline?
     
  15. tomisonbottom

    tomisonbottom Member

    Joined:
    Apr 17, 2013
    Messages:
    813
    I'm curious, what symptoms or lack thereof tell you it's prolactin getting lowered?

    Did it lower your prolactin?
     
  16. Elchapchapchapo

    Elchapchapchapo Member

    Joined:
    Jul 20, 2016
    Messages:
    214
    Gender:
    Male
    Lisuride and Bromo for sure did, these two really helpd me stop feeling like ***t from the raised prolactin, i felt like ******* garbage. I imagine meter would as my lift in libido was so noticable, but i couldnt handle the anti serotonin effects mood wise personally
     
  17. tomisonbottom

    tomisonbottom Member

    Joined:
    Apr 17, 2013
    Messages:
    813
    OK, thanks........when you say anti-serotonin effects, do you mean depression symptoms?
     
  18. Elchapchapchapo

    Elchapchapchapo Member

    Joined:
    Jul 20, 2016
    Messages:
    214
    Gender:
    Male
    Yeah it was kind of different then depression - it was like no feeling at all
     
  19. Experienced

    Experienced Member

    Joined:
    Feb 28, 2017
    Messages:
    122
    Gender:
    Male
    Location:
    Netherlands
    Months ago I can't remember exactly I'm sorry
     
  20. No_Energy

    No_Energy Member

    Joined:
    Dec 16, 2017
    Messages:
    16
    Gender:
    Male
    Hello everyone,
    Do you guys think MeterG. would have potential as a long-term treatment for depression/apathy/extreme fatigue (and/or negative symptoms of schizophrenia) ?.
     
Loading...