When taking metergoline and lisuride simultaneaously isn't the 5-HT1A antagonism of metergoline cancelled out by the lisuride agonism of the 5-HT1A?
If I administer cabergoline, a 5-HT2B agonist and metergoline, a 5-HT2B antagonist simultaneously to my rat, do the two cancel any effect on 5-HT2B ?
Cabergoline has a half life of about 3 days. Would metergoline have to be administered each of the 3 days to eliminate the agonist effect of cab?
Yes, you want 5-HT1 and 5-HT2B antagonism. So, combining metergoline or cyproheptadine with lisuride or cabergoline should help neutralize some of those side effects. I even posted a study showing cypro fully prevented the fibrotic effects of 5-HT2B agonists like cabergoline. And yes, if metergoline half life is shorter it will have to be used more often to balance the effects of cabergoline. Or you can use cypro as it has a half life of up to 12 hours in most people.