tyw
Member
Thanks for details.I appreciate also if you recall more and share , as you mentioned.
Probably I need to re read them to understand.
But I just think if the >500 MCG dose is what you think has the therapeutic value then the lower dose(but still higher than RDA/DRI) may do the trick but it just takes longer duration.
Like if you see improvements with dosage you mentioned in 2weeks, then with 100-150 mcg you see the improvements in 6-8 weeks.
Lower doses have not worked in practice. The recomended use cases of Molybdenum is either:
(1) Boost Molybdenum levels above baseline during initial treatment when Phase 1 and 2 liver detox is ramped up.
(2) As a short term ad-hoc supplement when known "high methylation requirement" foods are required (eg: going out for coffee + fatty snack)
In case (1), you want high doses anyway. This should be seen as a necessary evil to deal with purgation strategies.
In case (2), you want an acute high dose to elevate especially hepatic levels transiently, ideally for only the amount of time needed to deal with the incoming stressor. Lower doses defeat the purpose of this.
Molybdenum should still be treated as a trace mineral needed in small amounts for very specific things. The fact that it is very highly regulated indicates that some balance must be achieved (ie: chronic overdose is a problem).
The general philosophy applies: Dose a substance as much as tolerable, for as short a time possible needed for the desired effect.
As an sidenote, and as an example of this philosophy, I've seen some people complain that Betaine HCL does not work for them, only to realise that they are dosing low doses of 500-1000mg.
The recommendation for Betaine HCL dosing has always been -- increase dose until you feel a burning sensation in the throat and stomach, and then back off just a little bit (10-20%). Unless there is a pre-existing condition that warrants caution with the substance, then this protocol applies.
An effective dose is now established, and is to be used only during times when needed, like having to eat a larger-than-normal protein and fat rich meal for a family gathering. In practice, effective one-time doses are more commonly above 3,000mg (usually 5-6 tablets)
The recommendation for Betaine HCL dosing has always been -- increase dose until you feel a burning sensation in the throat and stomach, and then back off just a little bit (10-20%). Unless there is a pre-existing condition that warrants caution with the substance, then this protocol applies.
An effective dose is now established, and is to be used only during times when needed, like having to eat a larger-than-normal protein and fat rich meal for a family gathering. In practice, effective one-time doses are more commonly above 3,000mg (usually 5-6 tablets)
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