Melatonin Hinders Sperm Production By LOWERING Estrogen In Men?

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https://www.researchgate.net/profil...ealthy_men/links/541812070cf203f155ad92c0.pdf

We found a decrease in sperm concentration and motility below the normal range in 2 of 8 men enrolled in a double-blind study of daily treatment. Moreover, in these 2 men, we observed a decrease in seminal and blood E2 levels with a concomitant increase in testosterone:E2 ratios. Since the sequence of medications in these 2 men was placebo followed by melatonin, we conclude that the decrease in semen quality was associated with melatonin administration

A direct inhibitory effect of melatonin on sperm motility was suggested in several studies (Irez et al, 1992; Van Vuuren et al, 1992). It was suggested that melatonin inhibition might proceed by acting on sperm membranes or by binding to the tubulin of the sperm flagellum to decrease motility (Irez et al, 1992).

The ability of melatonin to suppress experimentally induced lipid peroxidation in sperm membranes was studied in infertile men.

Sperm incubated with melatonin showed a reduced rate of lipid peroxidation (Gavella and Lipovac, 2000). A more plausible explanation is that by inhibiting epididymal and testicular aromatase, melatonin caused a decrease in locally produced E2 and an increase in the androgen:estrogen balance, resulting in decreased sperm motility and concentration. E2 given daily to male rats induced inhibitory effects on spermatogenesis and serum testosterone levels.
 

Elephanto

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Interestingly, studies find that people with prostate cancer have low melatonin; and it is used experimentally to stop prostate tumor growth.
 
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ecstatichamster
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Ray says it lowers progesterone.

Sirotkin found that melatonin inhibits progesterone production but stimulates estrogen production, and it’s widely recognized that melatonin generally inhibits the thyroid hormones, creating an environment in which fertilization, implantation, and development of the embryo are not possible. This combination of high estrogen with low progesterone and low thyroid decreases the resistance of the organism, predisposing it to seizures and excitotoxic damage, and causing the thymus gland to atrophy.
 
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ecstatichamster
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I think it depends on whether endogenous or supplemented, and dosages if low vs high (but still physiological) and if taken with circadian rhythms or outside them.
 

DaveFoster

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I just had a thought. When people smoke weed, they raise their melatonin, and I've had some recurring events of stoner chicks with very odd libidos, almost numbed feelings. This might be related to melatonin's negative effect of sex steroids, along with marijuana's ability to raise cortisol.
 

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