Ray has written about several natural compounds that may be helpful for supporting optimal skin health in areas that have moles, spots, blemishes, etc. The natural compounds naringenin and apigenin are the ones most extensively researched for that purpose, but caffeine is also a very beneficial one and already used as part of the SolBan supplement. In addition to supporting skin health, caffeine also helps increase the absorption of both naringenin and apigenin, and that is another reason for its presence in MelaNon.
The topical doses used in most studies correspond to about 2mg for a human and that applies for both naringenin and apigenin.
Note: This product contains raw material(s) meant for external use only, in cosmetic or other formulations designed for such external use.
MelaNon is dietary supplement for skin health. It contains the citrus flavonoid naringenin as well as the flavone apigenin most commonly found in chamomile. MelaNon also contains caffeine for improved estrogen control and skin health. All of the ingredients have been extensively studies for health purposes, but most of the research on naringenin / apigenin focuses on their anti-neoplastic effects, and especially their effects on skin formations such as moles of various types. This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.
Servings per container: about 30
Serving size: 8 drops
Each serving (8 drops) contains the following ingredients:
Apigenin - 3mg
Naringenin - 3mg
Other ingredients: DMSO, ethanol.
http://www.functionalps.com/blog/2013/1 ... aringenin/
"...Orange juice contains naringenin which is effective against melanoma, and guavas contain apigenin, also effective. A diet consisting of milk, orange juice, guavas, cheese, and some eggs, liver, and oysters, with aspirin would be protective against the spread of the tumor.”
http://raypeat.com/articles/articles/th ... trix.shtml
"...Substances that inhibit inflammation are likely to also inhibit excessive collagen synthesis, serotonin secretion, and the formation of estrogen. Besides aspirin, some effective substances are apigenin and naringenin, found in oranges and guavas. These flavonoids also inhibit the formation of nitric oxide and prostaglandins, which are important for inflammation and carcinogenesis (Liang, et al., 1999). Increased CO2, which has a variety of anti-inflammatory effects, can decrease collagen formation and tissue collagen content significantly (Ryu, et al., 2010)."
Photoprotective and Antigenotoxic Effects of the Flavonoids Apigenin, Naringenin and Pinocembrin. - PubMed - NCBI
Citrus flavanone naringenin enhances melanogenesis through the activation of Wnt/β-catenin signalling in mouse melanoma cells. - PubMed - NCBI
Hydrolysates of citrus plants stimulate melanogenesis protecting against UV-induced dermal damage. - PubMed - NCBI
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to red... - PubMed - NCBI
In vitro cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines. - PubMed - NCBI
Stimulation of melanogenesis by the citrus flavonoid naringenin in mouse B16 melanoma cells. - PubMed - NCBI
Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. - PubMed - NCBI
Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice. - PubMed - NCBI
Chemopreventive and therapeutic potential of "naringenin," a flavanone present in citrus fruits. - PubMed - NCBI
Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest. - PubMed - NCBI
Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro. - PubMed - NCBI
Tumor growth attenuating effects of naringenin. - PubMed - NCBI
Inhibitory effect of GB-2a (I3-naringenin-II8-eriodictyol) on melanogenesis. - PubMed - NCBI
Preparation and Characterization of Naringenin-Loaded Elastic Liposomes for Topical Application. - PubMed - NCBI
The inhibitory effect of naringenin on atopic dermatitis induced by DNFB in NC/Nga mice. - PubMed - NCBI
Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoageing in human dermal fibrobolasts. - PubMed - NCBI
Naringenin protects HaCaT human keratinocytes against UVB-induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome. - PubMed - NCBI
Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. - PubMed - NCBI
Correlation of in vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels. - PubMed - NCBI
Apigenin: a promising molecule for cancer prevention. - PubMed - NCBI
Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. - PubMed - NCBI
Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic sig... - PubMed - NCBI
Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid. - PubMed - NCBI
Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1. - PubMed - NCBI
Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviole... - PubMed - NCBI
Topical apigenin alleviates cutaneous inflammation in murine models. - PubMed - NCBI
Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications. - PubMed - NCBI
Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells. - PubMed - NCBI
Src kinase is a direct target of apigenin against UVB-induced skin inflammation. - PubMed - NCBI
Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation. - PubMed - NCBI
Thanks for this Haidut!
Presumably this would be one to use directly on a mole rather than the 'tease the mole' technique with DHEA that Peat has spoken about?
A friend has psoriasis - might it be useful in combination with estroban?