MelaNon - Liquid Apigenin/Naringenin Mix

[pdonodog]

So has this solution worked for anyone in removing moles or brown spots yet? I have some I need to get rid of.

 

[DesertRat]

Are people using this combined with Solban? I have a little growth on my nose and I don't know how to classify it (it's not a mole or a brown spot) and am trying to decide if I should try MelaNon, Solban, or use a combination of the two?
The spot looks like a tiny pimple but I can't see a black or white center; it's been growing slowly for maybe 5 months.

 

[Peata]

If I were to start over, I would have used Solban with Melanon, alternating, from the beginning. I've been using Melanon with maybe a little result on the skinned knee scar after 7 weeks, but since I added Solban one week ago, it appears the results are coming a little faster.

 

[DesertRat]

Thanks Peata. Why is it necessary to alternate? or rather, do you do one each day, or can you do one in the morning and another at night?

 

[Peata]

post 118935 Thanks Peata. Why is it necessary to alternate? or rather, do you do one each day, or can you do one in the morning and another at night?

I use them in the same day. Such as Solban in the a.m. and Melanon at night.

 

[johnwester130]

Confused about this.

This will remove moles, and brown spots, and skin discolouration ?

Surely solban would be as effective ?

 

[haidut]

post 119018 Confused about this.

This will remove moles, and brown spots, and skin discolouration ?

Surely solban would be as effective ?

Both can be used since they have different mechanisms of action. As discussed earlier in the thread, I would use SolBan in the morning and MelaNon at night.

 

[GAF]

I have been using melanon daily on a weird brown spot thing on my upper chest. It is getting lighter and smaller but it is not gone yet. I took pic at beginning. When it is gone completely, I will post pics and dates.

 

[Peata]

post 119024 I have been using melanon daily on a weird brown spot thing on my upper chest. It is getting lighter and smaller but it is not gone yet. I took pic at beginning. When it is gone completely, I will post pics and dates.

How long have you been using it?

 

[GAF]

I bought it as soon as he released it, so looking at the first post that would have been about Mid November when I received the bottle. It seems to be just a slow process on this particular spot of shrinkage and lightening. It is not drying up and falling off. And this spot isn't a traditional "mole". It was just a dark and weird bump. Hard to describe because it doesn't look like anything else on my body. That is why I wanted it gone. Once, sometimes twice a day. One drop.

 

[Dan W]

My results haven't been as dramatic as some, but here they are so far:
Don't click here unless you want to see extreme close-ups of moles

 

[seano]

@haidut & all - Have you looked into topical iodine for scar healing?

http://www.thyroidscience.com/cases/Derry.Iodine.Regen.6.7.08.pdf

Searching around finds it is used a lot. Sometimes alone, or in solution with dmso, castor oil, ...

 

[ilovethesea]

Haidut, MelaNon is amazing. I have used it on 2 sebaceous hyperplasia spots (tiny flesh coloured bumps similar to milia) on my forehead and cheek. Ray talks about those in the rosacea article, they are related somehow to rosacea.

Anyway, nothing I ever did had any effect whatsoever and I was told by dermatologists nothing could be done. Some told me it was from oily skin but I don't really have oily skin, I have normal skin.

Anyway... MelaNon obliterated these problems within a few applications. I am shocked. It also works overnight on pimples.

I will be trying it on moles next, and getting a bottle for my mom to try on persistent skin tags.

Thank you for the incredible product!!!

 

[haidut]

Haidut, MelaNon is amazing. I have used it on 2 sebaceous hyperplasia spots (tiny flesh coloured bumps similar to milia) on my forehead and cheek. Ray talks about those in the rosacea article, they are related somehow to rosacea.

Anyway, nothing I ever did had any effect whatsoever and I was told by dermatologists nothing could be done. Some told me it was from oily skin but I don't really have oily skin, I have normal skin.

Anyway... MelaNon obliterated these problems within a few applications. I am shocked. It also works overnight on pimples.

I will be trying it on moles next, and getting a bottle for my mom to try on persistent skin tags.

Thank you for the incredible product!!!

This is simply awesome! :-D Thank you so much for sharing!

 

[TheHound]

is it supposed to be almost unbearably itchy when applied to a mole? or does this mean I'm allergic to something in it?

 

[Dan W]

"Title-ified" references:

Naringenin:

• Citrus flavanone naringenin enhances melanogenesis through the activation of Wnt/β-catenin signalling in mouse melanoma cells.
• Hydrolysates of citrus plants stimulate melanogenesis protecting against UV-induced dermal damage.
• Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to red...
• In vitro cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines.
• Stimulation of melanogenesis by the citrus flavonoid naringenin in mouse B16 melanoma cells.
• Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.
• Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice.
• Chemopreventive and therapeutic potential of "naringenin," a flavanone present in citrus fruits.
• Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest.
• Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro.
• Tumor growth attenuating effects of naringenin.
• Inhibitory effect of GB-2a (I3-naringenin-II8-eriodictyol) on melanogenesis.
• Preparation and Characterization of Naringenin-Loaded Elastic Liposomes for Topical Application.
• The inhibitory effect of naringenin on atopic dermatitis induced by DNFB in NC/Nga mice.
• Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoageing in human dermal fibrobolasts.
• Naringenin protects HaCaT human keratinocytes against UVB-induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome.
• Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids.
• Correlation of in vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels.

Apigenin:

• Apigenin: a promising molecule for cancer prevention.
• Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.
• Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic sig...
• Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid.
• Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1.
• Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviole...
• Topical apigenin alleviates cutaneous inflammation in murine models.
• Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications.
• Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells.
• Src kinase is a direct target of apigenin against UVB-induced skin inflammation.
• Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation.
• Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms.
• The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes.
• Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes.
• Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes.
• Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311.
• Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.
• Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures.
• Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice.
• Activation of p38 MAPK pathway contributes to the melanogenic property of apigenin in B16 cells.
• Treatment of dermatophytosis by a new antifungal agent 'apigenin'.
• Inhibition of Melanogenesis by Yeast Extracts from Cultivations of Recombinant Pichia pastoris Catalyzing ortho-Hydroxylation of Flavonoids.
• Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway.
• Chemoprevention of skin melanoma: facts and myths.
• Influence of vehicle, distant topical delivery, and biotransformation on the chemopreventive activity of apigenin, a plant flavonoid, in mouse skin.
• In vivo and in vitro percutaneous absorption of cancer preventive flavonoid apigenin in different vehicles in mouse skin.

Caffeine:

• Topical applications of caffeine or (epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice
• A novel topical targeting system of caffeine microemulsion for inhibiting UVB-induced skin tumor: characterization, optimization, and evaluation.
• Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.
• Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB treated mice
• Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice.
• Protection from photodamage by topical application of caffeine after ultraviolet irradiation.
• Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat.
• Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in mouse skin.

 

[Blossom]

You rock @Dan Wich

 

[tara]

is it supposed to be almost unbearably itchy when applied to a mole? or does this mean I'm allergic to something in it?

I'm finding using it straight to be itchy, but adding a couple of drops of water on the spot before adding the melanon prevents the itchiness.

 

[stokesman]

is it supposed to be almost unbearably itchy when applied to a mole? or does this mean I'm allergic to something in it?

I just came to recheck this thread because I thought I hadn't read any reports of such and wondered if I was the only one. I've been applying Melanon to moles and spots for about a week now and noticed itchiness only on some of the places I've applied it. My best guess was that it's akin to the itch I get on wounds as they are healing and that the spots where it didn't itch are relatively damage free. The spots that itched the most have been itching less and perhaps that supports the idea.

 

[TheHound]

I just came to recheck this thread because I thought I hadn't read any reports of such and wondered if I was the only one. I've been applying Melanon to moles and spots for about a week now and noticed itchiness only on some of the places I've applied it. My best guess was that it's akin to the itch I get on wounds as they are healing and that the spots where it didn't itch are relatively damage free. The spots that itched the most have been itching less and perhaps that supports the idea.

so it subsides? I've just tried applying it again. it made the area red accompanied by a fairly strong burning sensation. I'm not sure if this is normal